Tissue | GTEx Coverage  | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 100% | 5487.83 | 2633 / 2642 | 99% | 27.31 | 701 / 705 |
| prostate | 100% | 5511.66 | 244 / 245 | 99% | 21.57 | 498 / 502 |
| thymus | 100% | 5053.40 | 651 / 653 | 95% | 16.59 | 577 / 605 |
| kidney | 100% | 3012.34 | 89 / 89 | 91% | 16.62 | 818 / 901 |
| adrenal gland | 100% | 3095.71 | 257 / 258 | 86% | 19.06 | 197 / 230 |
| skin | 84% | 2595.81 | 1516 / 1809 | 97% | 36.45 | 459 / 472 |
| breast | 100% | 5454.64 | 458 / 459 | 76% | 10.47 | 847 / 1118 |
| lung | 99% | 5152.25 | 575 / 578 | 59% | 6.69 | 684 / 1155 |
| esophagus | 88% | 5067.77 | 1265 / 1445 | 68% | 8.93 | 124 / 183 |
| bladder | 100% | 6272.29 | 21 / 21 | 38% | 4.01 | 191 / 504 |
| uterus | 100% | 8167.72 | 170 / 170 | 36% | 5.18 | 167 / 459 |
| ovary | 100% | 8407.14 | 180 / 180 | 27% | 2.50 | 116 / 430 |
| intestine | 96% | 5819.95 | 931 / 966 | 28% | 2.60 | 149 / 527 |
| pancreas | 32% | 453.48 | 104 / 328 | 87% | 10.41 | 154 / 178 |
| stomach | 71% | 2839.41 | 255 / 359 | 47% | 4.77 | 133 / 286 |
| adipose | 100% | 6347.94 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 10085.25 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 100% | 2662.07 | 240 / 241 | 0% | 0 | 0 / 0 |
| heart | 90% | 2113.75 | 774 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 81% | 9.75 | 65 / 80 |
| tonsil | 0% | 0 | 0 / 0 | 60% | 5.41 | 27 / 45 |
| muscle | 54% | 861.88 | 435 / 803 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 41% | 3.28 | 12 / 29 |
| peripheral blood | 24% | 492.95 | 221 / 929 | 0% | 0 | 0 / 0 |
| liver | 5% | 75.45 | 12 / 226 | 16% | 1.85 | 65 / 406 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0018105 | Biological process | peptidyl-serine phosphorylation |
| GO_1905653 | Biological process | positive regulation of artery morphogenesis |
| GO_0043536 | Biological process | positive regulation of blood vessel endothelial cell migration |
| GO_0045766 | Biological process | positive regulation of angiogenesis |
| GO_0007165 | Biological process | signal transduction |
| GO_1905564 | Biological process | positive regulation of vascular endothelial cell proliferation |
| GO_0048873 | Biological process | homeostasis of number of cells within a tissue |
| GO_0090050 | Biological process | positive regulation of cell migration involved in sprouting angiogenesis |
| GO_0035556 | Biological process | intracellular signal transduction |
| GO_0001938 | Biological process | positive regulation of endothelial cell proliferation |
| GO_0048854 | Biological process | brain morphogenesis |
| GO_0045793 | Biological process | positive regulation of cell size |
| GO_0006468 | Biological process | protein phosphorylation |
| GO_0000002 | Biological process | mitochondrial genome maintenance |
| GO_0032008 | Biological process | positive regulation of TOR signaling |
| GO_2000773 | Biological process | negative regulation of cellular senescence |
| GO_0016020 | Cellular component | membrane |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0106310 | Molecular function | protein serine kinase activity |
| GO_0004674 | Molecular function | protein serine/threonine kinase activity |
| GO_0004672 | Molecular function | protein kinase activity |
| GO_0005524 | Molecular function | ATP binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | AKT3 |
| Protein name | non-specific serine/threonine protein kinase (EC 2.7.11.1) RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-3) (Protein kinase B gamma) (PKB gamma) (RAC-PK-gamma) (STK-2) AKT serine/threonine kinase 3 RAC-gamma serine/threonine-protein kinase |
| Synonyms | PKBG |
| Description | FUNCTION: AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis. . |
| Accessions | ENST00000629115.1 ENST00000672238.1 A0A7P0T8T9 ENST00000492957.2 ENST00000680118.1 [Q9Y243-1] ENST00000613395.4 [Q9Y243-2] ENST00000672460.1 ENST00000672442.1 ENST00000621586.3 [Q9Y243-1] A0A7P0TBJ6 Q9Y243 ENST00000681794.1 ENST00000366540.5 [Q9Y243-2] A0A5F9ZGY0 A0A5F9ZHA9 ENST00000673466.1 [Q9Y243-1] A0A7P0TB29 Q56A86 A0A7P0T872 A0A7P0TB32 ENST00000491219.6 F8VS91 A0A5K1VW74 ENST00000336199.9 [Q9Y243-2] ENST00000673400.1 ENST00000672578.1 A0A5F9ZHU3 ENST00000263826.12 [Q9Y243-1] A0A5F9ZGZ4 ENST00000680056.1 ENST00000366539.6 ENST00000619536.4 [Q9Y243-2] |
