Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| hematopoietic precursor cell | 4 studies | 28% ± 12% | |
| natural killer cell | 4 studies | 22% ± 5% | |
| CD4-positive, alpha-beta T cell | 4 studies | 19% ± 3% | |
| ciliated cell | 3 studies | 21% ± 3% | |
| epithelial cell | 3 studies | 26% ± 6% | |
| erythroblast | 3 studies | 37% ± 21% | |
| GABAergic neuron | 3 studies | 43% ± 8% | |
| glutamatergic neuron | 3 studies | 56% ± 3% | |
| transit amplifying cell | 3 studies | 37% ± 19% | |
| CD8-positive, alpha-beta T cell | 3 studies | 18% ± 1% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 100% | 515.67 | 459 / 459 | 100% | 22.69 | 1116 / 1118 |
| uterus | 100% | 448.75 | 170 / 170 | 100% | 38.15 | 458 / 459 |
| ovary | 100% | 402.67 | 180 / 180 | 100% | 21.04 | 429 / 430 |
| esophagus | 100% | 472.64 | 1445 / 1445 | 99% | 20.95 | 182 / 183 |
| bladder | 100% | 443.52 | 21 / 21 | 99% | 28.18 | 499 / 504 |
| lung | 99% | 361.63 | 571 / 578 | 100% | 23.00 | 1152 / 1155 |
| stomach | 100% | 481.45 | 359 / 359 | 98% | 22.45 | 281 / 286 |
| intestine | 100% | 497.13 | 966 / 966 | 98% | 25.29 | 517 / 527 |
| thymus | 100% | 343.67 | 651 / 653 | 98% | 18.57 | 595 / 605 |
| brain | 100% | 466.13 | 2631 / 2642 | 98% | 12.70 | 691 / 705 |
| prostate | 100% | 321.40 | 244 / 245 | 98% | 10.97 | 490 / 502 |
| skin | 100% | 686.16 | 1807 / 1809 | 96% | 19.43 | 451 / 472 |
| pancreas | 88% | 152.69 | 288 / 328 | 97% | 14.08 | 173 / 178 |
| kidney | 97% | 253.39 | 86 / 89 | 80% | 7.44 | 724 / 901 |
| adrenal gland | 100% | 306.64 | 257 / 258 | 77% | 7.50 | 177 / 230 |
| liver | 80% | 124.41 | 180 / 226 | 68% | 6.98 | 276 / 406 |
| adipose | 100% | 444.68 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 53.85 | 29 / 29 |
| spleen | 100% | 908.94 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 34.06 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 15.97 | 1 / 1 |
| blood vessel | 100% | 337.74 | 1329 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 97% | 191.25 | 777 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 96% | 1085.13 | 892 / 929 | 0% | 0 | 0 / 0 |
| heart | 94% | 223.30 | 808 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 65% | 6.79 | 52 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0018105 | Biological process | peptidyl-serine phosphorylation |
| GO_0120187 | Biological process | positive regulation of protein localization to chromatin |
| GO_0090166 | Biological process | Golgi disassembly |
| GO_2001222 | Biological process | regulation of neuron migration |
| GO_0031175 | Biological process | neuron projection development |
| GO_0007165 | Biological process | signal transduction |
| GO_0006974 | Biological process | DNA damage response |
| GO_0007077 | Biological process | mitotic nuclear membrane disassembly |
| GO_0051301 | Biological process | cell division |
| GO_0030576 | Biological process | Cajal body organization |
| GO_0006338 | Biological process | chromatin remodeling |
| GO_0006468 | Biological process | protein phosphorylation |
| GO_0046777 | Biological process | protein autophosphorylation |
| GO_0005795 | Cellular component | Golgi stack |
| GO_0005730 | Cellular component | nucleolus |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0015030 | Cellular component | Cajal body |
| GO_0000785 | Cellular component | chromatin |
| GO_0005634 | Cellular component | nucleus |
| GO_0072354 | Molecular function | histone H3T3 kinase activity |
| GO_0106310 | Molecular function | protein serine kinase activity |
| GO_0042393 | Molecular function | histone binding |
| GO_0031492 | Molecular function | nucleosomal DNA binding |
| GO_0019901 | Molecular function | protein kinase binding |
| GO_0004674 | Molecular function | protein serine/threonine kinase activity |
| GO_0004672 | Molecular function | protein kinase activity |
| GO_0035175 | Molecular function | histone H3S10 kinase activity |
| GO_0005524 | Molecular function | ATP binding |
| GO_0016301 | Molecular function | kinase activity |
| GO_0141003 | Molecular function | histone H2AX kinase activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | VRK1 |
| Protein name | non-specific serine/threonine protein kinase (EC 2.7.11.1) VRK serine/threonine kinase 1 Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1) |
| Synonyms | hCG_24514 |
| Description | FUNCTION: Serine/threonine kinase involved in cell cycle, nuclear condensation and transcription regulation . Involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation . Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2 . Phosphorylates KAT5 in response to DNA damage, promoting KAT5 association with chromatin and histone acetyltransferase activity . Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm . Phosphorylates ATF2 which activates its transcriptional activity . . |
| Accessions | ENST00000680509.1 ENST00000680384.1 ENST00000680222.1 ENST00000680335.1 ENST00000679977.1 ENST00000681695.1 A0A7P0T9B1 A0A7P0T8M0 ENST00000681249.1 A0A7P0T814 A0A7P0TA65 H0YJF7 A0A7P0T832 ENST00000679758.1 A0A7P0TBB8 A0A7P0TAS8 A0A7P0TAA6 A0A7P0TB08 ENST00000679918.1 ENST00000680526.1 A0A7P0T9T1 ENST00000216639.8 ENST00000679903.1 A0A7P0Z3Z7 ENST00000680339.1 A0A7P0T9E5 ENST00000679770.1 ENST00000680849.1 ENST00000679727.1 ENST00000680387.1 Q99986 A0A7P0TA07 ENST00000679650.1 ENST00000681077.1 ENST00000681419.1 ENST00000681176.1 ENST00000681538.1 A0A7P0T977 ENST00000681493.1 ENST00000680724.1 ENST00000680851.1 ENST00000679843.1 A0A7P0Z4P9 ENST00000679533.1 ENST00000679941.1 ENST00000681677.1 ENST00000680538.1 A0A7P0T824 ENST00000553683.2 ENST00000681785.1 A0A7P0TBE4 A0A7P0Z4A4 ENST00000681474.1 ENST00000680922.1 A0A7P0TBI6 A0A7P0T833 A0A7P0TAI5 ENST00000681355.1 A0A7P0T9C6 ENST00000679452.1 ENST00000681061.1 ENST00000681778.1 A0A7P0Z4C8 A0A7P0Z462 H0YJJ9 ENST00000679365.1 ENST00000679736.1 ENST00000680993.1 A0A7P0Z445 ENST00000681101.1 A0A7P0TB15 A0A7P0T8Z5 A0A7P0TA16 ENST00000679816.1 A0A7P0TB37 ENST00000681195.1 ENST00000681344.1 A0A7P0T952 ENST00000557352.2 ENST00000681524.1 ENST00000681363.1 ENST00000680007.1 ENST00000679462.1 ENST00000557222.6 ENST00000681598.1 A0A7P0T925 A0A7P0T838 A0A7P0T9I1 ENST00000680756.1 ENST00000680348.1 ENST00000680683.1 H0YJ50 A0A7P0T8N0 |
