AFDN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0010628Biological processpositive regulation of gene expression
GO_0032880Biological processregulation of protein localization
GO_0007155Biological processcell adhesion
GO_0044331Biological processcell-cell adhesion mediated by cadherin
GO_0007267Biological processcell-cell signaling
GO_0046931Biological processpore complex assembly
GO_0070830Biological processbicellular tight junction assembly
GO_2000049Biological processpositive regulation of cell-cell adhesion mediated by cadherin
GO_0090557Biological processestablishment of endothelial intestinal barrier
GO_0030336Biological processnegative regulation of cell migration
GO_0061951Biological processestablishment of protein localization to plasma membrane
GO_0022409Biological processpositive regulation of cell-cell adhesion
GO_0070160Cellular componenttight junction
GO_0005886Cellular componentplasma membrane
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0044291Cellular componentcell-cell contact zone
GO_0005911Cellular componentcell-cell junction
GO_0005829Cellular componentcytosol
GO_0005912Cellular componentadherens junction
GO_0046930Cellular componentpore complex
GO_0030054Cellular componentcell junction
GO_0045296Molecular functioncadherin binding
GO_0051015Molecular functionactin filament binding
GO_0031267Molecular functionsmall GTPase binding
GO_0050839Molecular functioncell adhesion molecule binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameAFDN
Protein nameMLLT4 protein
Afadin
Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor)
Afadin, adherens junction formation factor
SynonymsMLLT4
AF6
DescriptionFUNCTION: Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton . May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions . .

AccessionsENST00000515794.3
ENST00000447894.6 [P55196-4]
ENST00000392108.7 [P55196-6]
ENST00000351017.9
H0Y9I0
ENST00000476946.2
A0A804HJ20
ENST00000392112.5 [P55196-3]
ENST00000423229.1
ENST00000344191.8
ENST00000683244.1
J3KN01
H0Y8L4
ENST00000507704.5
H0YA98
Q5TIG5
ENST00000400822.7 [P55196-5]
H0Y948
ENST00000400825.8
H0Y7R8
ENST00000366806.6
E9PFY5
F8W9I4
G1UI22
Q96C95
ENST00000400824.8
H0Y8U8
P55196
ENST00000485634.7
ENST00000497596.2
A8MQ02