Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 39 studies | 43% ± 17% | |
| ciliated cell | 17 studies | 53% ± 16% | |
| capillary endothelial cell | 15 studies | 32% ± 15% | |
| astrocyte | 15 studies | 46% ± 19% | |
| endothelial cell of lymphatic vessel | 14 studies | 39% ± 17% | |
| fibroblast | 14 studies | 32% ± 15% | |
| epithelial cell | 13 studies | 42% ± 25% | |
| glutamatergic neuron | 12 studies | 44% ± 22% | |
| oligodendrocyte | 12 studies | 43% ± 16% | |
| endothelial cell of artery | 12 studies | 38% ± 13% | |
| vein endothelial cell | 11 studies | 36% ± 17% | |
| oligodendrocyte precursor cell | 11 studies | 46% ± 21% | |
| type I pneumocyte | 10 studies | 45% ± 20% | |
| GABAergic neuron | 10 studies | 51% ± 20% | |
| basal cell | 10 studies | 34% ± 16% | |
| mesothelial cell | 9 studies | 39% ± 10% | |
| amacrine cell | 8 studies | 36% ± 19% | |
| endothelial cell of vascular tree | 8 studies | 30% ± 19% | |
| microglial cell | 7 studies | 26% ± 10% | |
| secretory cell | 7 studies | 30% ± 11% | |
| type II pneumocyte | 6 studies | 31% ± 12% | |
| retina horizontal cell | 6 studies | 56% ± 11% | |
| Mueller cell | 6 studies | 48% ± 20% | |
| neuron | 5 studies | 51% ± 19% | |
| retinal bipolar neuron | 5 studies | 21% ± 3% | |
| retinal ganglion cell | 5 studies | 39% ± 14% | |
| kidney loop of Henle epithelial cell | 5 studies | 26% ± 11% | |
| club cell | 5 studies | 44% ± 13% | |
| adipocyte | 5 studies | 25% ± 5% | |
| goblet cell | 5 studies | 37% ± 20% | |
| interneuron | 5 studies | 65% ± 16% | |
| squamous epithelial cell | 4 studies | 63% ± 17% | |
| pericyte | 4 studies | 29% ± 11% | |
| retinal pigment epithelial cell | 4 studies | 36% ± 19% | |
| respiratory goblet cell | 4 studies | 44% ± 16% | |
| luminal cell of prostate epithelium | 4 studies | 30% ± 7% | |
| brush cell | 4 studies | 21% ± 4% | |
| enteroendocrine cell | 4 studies | 27% ± 6% | |
| macrophage | 4 studies | 21% ± 4% | |
| smooth muscle cell | 4 studies | 25% ± 6% | |
| ionocyte | 3 studies | 38% ± 8% | |
| glomerular endothelial cell | 3 studies | 25% ± 1% | |
| progenitor cell | 3 studies | 42% ± 28% | |
| retinal cone cell | 3 studies | 23% ± 6% | |
| cardiac muscle cell | 3 studies | 20% ± 2% | |
| GABAergic amacrine cell | 3 studies | 33% ± 11% | |
| OFF-bipolar cell | 3 studies | 31% ± 8% | |
| ON-bipolar cell | 3 studies | 24% ± 7% | |
| glycinergic amacrine cell | 3 studies | 31% ± 10% | |
| rod bipolar cell | 3 studies | 26% ± 8% | |
| monocyte | 3 studies | 27% ± 15% | |
| abnormal cell | 3 studies | 33% ± 22% | |
| connective tissue cell | 3 studies | 39% ± 2% | |
| ependymal cell | 3 studies | 47% ± 14% | |
| transit amplifying cell | 3 studies | 40% ± 30% | |
| granule cell | 3 studies | 33% ± 9% | |
| hepatocyte | 3 studies | 73% ± 11% | |
| kidney distal convoluted tubule epithelial cell | 3 studies | 26% ± 9% | |
| renal alpha-intercalated cell | 3 studies | 25% ± 9% | |
| renal principal cell | 3 studies | 30% ± 9% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 100% | 8660.76 | 245 / 245 | 100% | 48.08 | 500 / 502 |
| esophagus | 100% | 12174.40 | 1444 / 1445 | 99% | 43.84 | 182 / 183 |
| stomach | 100% | 7766.85 | 359 / 359 | 99% | 34.86 | 284 / 286 |
| intestine | 100% | 9105.65 | 966 / 966 | 99% | 34.13 | 523 / 527 |
| lung | 100% | 13287.35 | 578 / 578 | 99% | 29.24 | 1139 / 1155 |
| ovary | 100% | 7495.74 | 180 / 180 | 98% | 31.11 | 421 / 430 |
| breast | 100% | 12392.39 | 459 / 459 | 98% | 38.45 | 1093 / 1118 |
| kidney | 100% | 6846.82 | 89 / 89 | 97% | 27.19 | 875 / 901 |
| pancreas | 100% | 7686.02 | 328 / 328 | 97% | 27.36 | 172 / 178 |
| uterus | 100% | 8517.68 | 170 / 170 | 95% | 23.32 | 438 / 459 |
| bladder | 100% | 7131.24 | 21 / 21 | 95% | 21.77 | 477 / 504 |
| brain | 97% | 4005.38 | 2563 / 2642 | 96% | 19.32 | 675 / 705 |
| liver | 100% | 7788.50 | 226 / 226 | 91% | 20.01 | 371 / 406 |
| thymus | 100% | 11961.46 | 653 / 653 | 91% | 35.99 | 552 / 605 |
| adrenal gland | 100% | 3363.16 | 258 / 258 | 69% | 9.69 | 158 / 230 |
| skin | 98% | 9366.15 | 1781 / 1809 | 69% | 11.54 | 328 / 472 |
| adipose | 100% | 10198.24 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 100% | 7338.70 | 241 / 241 | 0% | 0 | 0 / 0 |
| heart | 100% | 5810.30 | 860 / 861 | 0% | 0 | 0 / 0 |
| blood vessel | 99% | 4255.79 | 1321 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 99% | 3811.03 | 791 / 803 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 96% | 23.86 | 43 / 45 |
| eye | 0% | 0 | 0 / 0 | 78% | 12.14 | 62 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 45% | 5.23 | 13 / 29 |
| peripheral blood | 19% | 1058.84 | 172 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0007165 | Biological process | signal transduction |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_0032880 | Biological process | regulation of protein localization |
| GO_0007155 | Biological process | cell adhesion |
| GO_0044331 | Biological process | cell-cell adhesion mediated by cadherin |
| GO_0007267 | Biological process | cell-cell signaling |
| GO_0046931 | Biological process | pore complex assembly |
| GO_0070830 | Biological process | bicellular tight junction assembly |
| GO_2000049 | Biological process | positive regulation of cell-cell adhesion mediated by cadherin |
| GO_0090557 | Biological process | establishment of endothelial intestinal barrier |
| GO_0030336 | Biological process | negative regulation of cell migration |
| GO_0061951 | Biological process | establishment of protein localization to plasma membrane |
| GO_0022409 | Biological process | positive regulation of cell-cell adhesion |
| GO_0070160 | Cellular component | tight junction |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016607 | Cellular component | nuclear speck |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0044291 | Cellular component | cell-cell contact zone |
| GO_0005911 | Cellular component | cell-cell junction |
| GO_0005829 | Cellular component | cytosol |
| GO_0005912 | Cellular component | adherens junction |
| GO_0046930 | Cellular component | pore complex |
| GO_0030054 | Cellular component | cell junction |
| GO_0045296 | Molecular function | cadherin binding |
| GO_0051015 | Molecular function | actin filament binding |
| GO_0031267 | Molecular function | small GTPase binding |
| GO_0050839 | Molecular function | cell adhesion molecule binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | AFDN |
| Protein name | MLLT4 protein Afadin Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) Afadin, adherens junction formation factor |
| Synonyms | MLLT4 AF6 |
| Description | FUNCTION: Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton . May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions . . |
| Accessions | ENST00000515794.3 ENST00000447894.6 [P55196-4] ENST00000392108.7 [P55196-6] ENST00000351017.9 H0Y9I0 ENST00000476946.2 A0A804HJ20 ENST00000392112.5 [P55196-3] ENST00000423229.1 ENST00000344191.8 ENST00000683244.1 J3KN01 H0Y8L4 ENST00000507704.5 H0YA98 Q5TIG5 ENST00000400822.7 [P55196-5] H0Y948 ENST00000400825.8 H0Y7R8 ENST00000366806.6 E9PFY5 F8W9I4 G1UI22 Q96C95 ENST00000400824.8 H0Y8U8 P55196 ENST00000485634.7 ENST00000497596.2 A8MQ02 |