LTB | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	47 studies	63% ± 19%	Explore
CD4-positive, alpha-beta T cell	37 studies	68% ± 24%	Explore
CD8-positive, alpha-beta T cell	33 studies	46% ± 23%	Explore
T cell	32 studies	49% ± 22%	Explore
regulatory T cell	29 studies	77% ± 16%	Explore
plasmacytoid dendritic cell	25 studies	58% ± 18%	Explore
memory B cell	21 studies	76% ± 19%	Explore
naive B cell	20 studies	74% ± 14%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	19 studies	80% ± 15%	Explore
natural killer cell	18 studies	29% ± 13%	Explore
mucosal invariant T cell	16 studies	69% ± 17%	Explore
gamma-delta T cell	16 studies	38% ± 17%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	15 studies	68% ± 22%	Explore
innate lymphoid cell	13 studies	55% ± 23%	Explore
CD4-positive, alpha-beta memory T cell	13 studies	71% ± 24%	Explore
conventional dendritic cell	13 studies	27% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	43% ± 23%	Explore
non-classical monocyte	11 studies	31% ± 9%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	36% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	38% ± 20%	Explore
T follicular helper cell	9 studies	67% ± 14%	Explore
mature NK T cell	8 studies	49% ± 22%	Explore
dendritic cell	7 studies	27% ± 14%	Explore
CD4-positive helper T cell	6 studies	59% ± 12%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	69% ± 25%	Explore
immature B cell	6 studies	82% ± 23%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	82% ± 24%	Explore
exhausted T cell	5 studies	57% ± 22%	Explore
monocyte	5 studies	26% ± 7%	Explore
platelet	5 studies	34% ± 13%	Explore
leukocyte	5 studies	33% ± 10%	Explore
precursor B cell	5 studies	50% ± 14%	Explore
pro-B cell	5 studies	55% ± 11%	Explore
T-helper 17 cell	5 studies	84% ± 13%	Explore
group 3 innate lymphoid cell	5 studies	87% ± 11%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	63% ± 28%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	60% ± 22%	Explore
neutrophil	4 studies	28% ± 9%	Explore
germinal center B cell	4 studies	72% ± 13%	Explore
T-helper 1 cell	4 studies	84% ± 13%	Explore
double negative thymocyte	4 studies	50% ± 23%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	63% ± 27%	Explore
erythrocyte	4 studies	41% ± 15%	Explore
plasmablast	3 studies	35% ± 16%	Explore
thymocyte	3 studies	60% ± 18%	Explore
follicular B cell	3 studies	82% ± 2%	Explore
intraepithelial lymphocyte	3 studies	36% ± 20%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	86% ± 15%	Explore
double-positive, alpha-beta thymocyte	3 studies	67% ± 14%	Explore
CD16-positive, CD56-dim natural killer cell, human	3 studies	35% ± 24%	Explore
plasma cell	3 studies	49% ± 19%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	21 studies	41% ± 14%	Explore
lymph node	5 studies	66% ± 7%	Explore
lung	4 studies	33% ± 13%	Explore
intestine	4 studies	30% ± 6%	Explore
bone marrow	3 studies	45% ± 12%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	375.23	576 / 578	89%	34.64	1025 / 1155
kidney	97%	379.06	86 / 89	73%	15.85	657 / 901
liver	79%	98.49	178 / 226	67%	31.90	271 / 406
intestine	64%	700.12	618 / 966	80%	22.90	419 / 527
bladder	67%	107.29	14 / 21	70%	20.09	355 / 504
stomach	53%	74.16	189 / 359	79%	21.94	226 / 286
pancreas	36%	55.97	118 / 328	89%	49.20	159 / 178
thymus	54%	174.66	351 / 653	65%	97.09	395 / 605
prostate	62%	106.16	152 / 245	55%	11.80	276 / 502
breast	51%	46.95	233 / 459	64%	23.38	712 / 1118
skin	45%	45.75	818 / 1809	65%	35.92	306 / 472
uterus	25%	17.39	42 / 170	80%	33.28	368 / 459
esophagus	36%	64.90	516 / 1445	68%	19.75	125 / 183
lymph node	0%	0	0 / 0	100%	588.36	29 / 29
peripheral blood	100%	5881.99	929 / 929	0%	0	0 / 0
spleen	100%	8874.57	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	93%	64.56	42 / 45
ovary	12%	8.68	21 / 180	68%	24.56	292 / 430
adipose	78%	115.09	938 / 1204	0%	0	0 / 0
adrenal gland	30%	22.45	78 / 258	17%	2.51	40 / 230
brain	40%	24.66	1070 / 2642	6%	1.59	42 / 705
blood vessel	27%	51.87	361 / 1335	0%	0	0 / 0
heart	20%	17.33	169 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	14%	3.49	11 / 80
muscle	4%	2.32	29 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0007165	Biological process	signal transduction
GO_0006955	Biological process	immune response
GO_0010467	Biological process	gene expression
GO_0032735	Biological process	positive regulation of interleukin-12 production
GO_2001238	Biological process	positive regulation of extrinsic apoptotic signaling pathway
GO_0043588	Biological process	skin development
GO_0043123	Biological process	positive regulation of canonical NF-kappaB signal transduction
GO_0048535	Biological process	lymph node development
GO_0007267	Biological process	cell-cell signaling
GO_0005575	Cellular component	cellular_component
GO_0005615	Cellular component	extracellular space
GO_0005886	Cellular component	plasma membrane
GO_0005164	Molecular function	tumor necrosis factor receptor binding
GO_0005102	Molecular function	signaling receptor binding
GO_0005125	Molecular function	cytokine activity

IV. Literature review

[source]

Gene name	LTB
Protein name	Lymphotoxin-beta (Tumor necrosis factor C) (Tumor necrosis factor ligand superfamily member 3) Lymphotoxin-beta (LT-beta) (Tumor necrosis factor C) (TNF-C) (Tumor necrosis factor ligand superfamily member 3)
Synonyms	TNFC hCG_43683 TNFSF3
Description	FUNCTION: Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional.
Accessions	ENST00000383493.2 [Q06643-1] ENST00000429299.3 [Q06643-1] ENST00000420402.2 [Q06643-1] ENST00000456113.2 [Q06643-1] ENST00000444479.2 [Q06643-1] ENST00000421268.2 [Q06643-1] ENST00000376117.3 [Q06643-1] Q06643 ENST00000457552.2 [Q06643-1] ENST00000446745.2 [Q06643-2] Q5STB2

LTB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review