ANK3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010650Biological processpositive regulation of cell communication by electrical coupling
GO_2001259Biological processpositive regulation of cation channel activity
GO_1900827Biological processpositive regulation of membrane depolarization during cardiac muscle cell action potential
GO_0072660Biological processmaintenance of protein location in plasma membrane
GO_0072659Biological processprotein localization to plasma membrane
GO_0045184Biological processestablishment of protein localization
GO_0007165Biological processsignal transduction
GO_0010628Biological processpositive regulation of gene expression
GO_0000281Biological processmitotic cytokinesis
GO_0007010Biological processcytoskeleton organization
GO_0043266Biological processregulation of potassium ion transport
GO_0099612Biological processprotein localization to axon
GO_0007528Biological processneuromuscular junction development
GO_0071286Biological processcellular response to magnesium ion
GO_0007409Biological processaxonogenesis
GO_1902260Biological processnegative regulation of delayed rectifier potassium channel activity
GO_0010765Biological processpositive regulation of sodium ion transport
GO_0045838Biological processpositive regulation of membrane potential
GO_0019228Biological processneuronal action potential
GO_0007009Biological processplasma membrane organization
GO_0090314Biological processpositive regulation of protein targeting to membrane
GO_2000651Biological processpositive regulation of sodium ion transmembrane transporter activity
GO_0010960Biological processmagnesium ion homeostasis
GO_0034112Biological processpositive regulation of homotypic cell-cell adhesion
GO_0071709Biological processmembrane assembly
GO_0043001Biological processGolgi to plasma membrane protein transport
GO_0005886Cellular componentplasma membrane
GO_0031594Cellular componentneuromuscular junction
GO_0043034Cellular componentcostamere
GO_0030018Cellular componentZ disc
GO_0005764Cellular componentlysosome
GO_0042383Cellular componentsarcolemma
GO_0043194Cellular componentaxon initial segment
GO_0005794Cellular componentGolgi apparatus
GO_0009925Cellular componentbasal plasma membrane
GO_0043005Cellular componentneuron projection
GO_0030425Cellular componentdendrite
GO_0014731Cellular componentspectrin-associated cytoskeleton
GO_0009986Cellular componentcell surface
GO_0030315Cellular componentT-tubule
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0016529Cellular componentsarcoplasmic reticulum
GO_0016328Cellular componentlateral plasma membrane
GO_0045211Cellular componentpostsynaptic membrane
GO_0005923Cellular componentbicellular tight junction
GO_0033268Cellular componentnode of Ranvier
GO_0014704Cellular componentintercalated disc
GO_0016323Cellular componentbasolateral plasma membrane
GO_0030507Molecular functionspectrin binding
GO_0045296Molecular functioncadherin binding
GO_0005200Molecular functionstructural constituent of cytoskeleton
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0044325Molecular functiontransmembrane transporter binding
GO_0008093Molecular functioncytoskeletal anchor activity
GO_0008092Molecular functioncytoskeletal protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameANK3
Protein nameAnkyrin 3, node of Ranvier (Ankyrin G), isoform CRA_d (cDNA FLJ78657, highly similar to Homo sapiens ankyrin 3, node of Ranvier (ankyrin G) (ANK3), transcript variant 2, mRNA)
Ankyrin-3 (ANK-3) (Ankyrin-G)
Ankyrin 3
SynonymshCG_1812776
DescriptionFUNCTION: Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments . In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption . Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). .; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. .

AccessionsA0A087X0L3
D6RHY3
ENST00000474360.1
A0A087WY90
D6RFK6
H0Y951
ENST00000280772.7 [Q12955-3]
ENST00000618080.4
H0YA66
ENST00000616444.4
Q12955
A8KA62
ENST00000617800.4
ENST00000506635.5
ENST00000373820.5
A0A087WX55
B1AQT1
A0A087WTP5
ENST00000503366.6 [Q12955-4]
ENST00000613207.4
A0A087WZ65
ENST00000460468.5
ENST00000373827.6 [Q12955-5]
ENST00000610321.4
H0Y8Z4
ENST00000514197.5
A0A087WVC2
ENST00000610901.4
A0A087WTE8
H0YAH5
ENST00000622427.4
ENST00000612776.4
D6RBY7
ENST00000503925.1
ENST00000373815.5
ENST00000486349.2
ENST00000511043.5
A0A087X0B4
H0Y3A4
A0A087WTF3
ENST00000513049.5
ENST00000459732.2
ENST00000467420.7
A0A087WWI5
ENST00000355288.6 [Q12955-6]
A0A087WZ26
D6RF31
H0Y9E9
ENST00000502769.5
ENST00000621739.1