Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| peripheral blood | 12 studies | 21% ± 3% | |
| lung | 9 studies | 24% ± 9% | |
| brain | 8 studies | 31% ± 16% | |
| eye | 6 studies | 22% ± 4% | |
| adipose | 4 studies | 20% ± 2% | |
| pancreas | 3 studies | 34% ± 11% | |
| kidney | 3 studies | 26% ± 5% | |
| uterus | 3 studies | 23% ± 8% | |
| liver | 3 studies | 25% ± 7% | |
| intestine | 3 studies | 19% ± 1% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| adrenal gland | 100% | 9405.58 | 258 / 258 | 100% | 101.94 | 230 / 230 |
| esophagus | 100% | 6615.22 | 1445 / 1445 | 100% | 54.32 | 183 / 183 |
| intestine | 100% | 7181.02 | 966 / 966 | 100% | 57.79 | 526 / 527 |
| lung | 100% | 7647.92 | 577 / 578 | 100% | 53.38 | 1150 / 1155 |
| liver | 100% | 3879.43 | 225 / 226 | 100% | 71.90 | 405 / 406 |
| stomach | 100% | 4385.50 | 359 / 359 | 99% | 54.23 | 284 / 286 |
| kidney | 100% | 6751.78 | 89 / 89 | 99% | 89.14 | 894 / 901 |
| uterus | 100% | 6385.47 | 170 / 170 | 99% | 67.19 | 454 / 459 |
| brain | 99% | 7186.92 | 2627 / 2642 | 99% | 54.66 | 701 / 705 |
| breast | 100% | 8974.14 | 459 / 459 | 99% | 66.96 | 1103 / 1118 |
| ovary | 100% | 10050.73 | 180 / 180 | 98% | 62.47 | 423 / 430 |
| bladder | 100% | 6119.43 | 21 / 21 | 98% | 63.20 | 495 / 504 |
| thymus | 99% | 3971.52 | 646 / 653 | 99% | 47.02 | 600 / 605 |
| skin | 100% | 8646.36 | 1808 / 1809 | 95% | 61.35 | 447 / 472 |
| prostate | 99% | 4953.98 | 243 / 245 | 91% | 30.62 | 459 / 502 |
| pancreas | 89% | 2510.24 | 292 / 328 | 99% | 81.52 | 177 / 178 |
| adipose | 100% | 10823.75 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 10468.10 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 69.73 | 29 / 29 |
| muscle | 100% | 67261.96 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 6017.17 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 72.48 | 45 / 45 |
| heart | 98% | 8118.04 | 848 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 94% | 61.22 | 75 / 80 |
| peripheral blood | 88% | 4075.23 | 816 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0034620 | Biological process | cellular response to unfolded protein |
| GO_0090161 | Biological process | Golgi ribbon formation |
| GO_0008219 | Biological process | cell death |
| GO_0045087 | Biological process | innate immune response |
| GO_0050829 | Biological process | defense response to Gram-negative bacterium |
| GO_0007165 | Biological process | signal transduction |
| GO_0061734 | Biological process | parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization |
| GO_1904417 | Biological process | positive regulation of xenophagy |
| GO_0034067 | Biological process | protein localization to Golgi apparatus |
| GO_0007030 | Biological process | Golgi organization |
| GO_0010508 | Biological process | positive regulation of autophagy |
| GO_0006914 | Biological process | autophagy |
| GO_0043122 | Biological process | regulation of canonical NF-kappaB signal transduction |
| GO_0043001 | Biological process | Golgi to plasma membrane protein transport |
| GO_0001920 | Biological process | negative regulation of receptor recycling |
| GO_0043124 | Biological process | negative regulation of canonical NF-kappaB signal transduction |
| GO_0048471 | Cellular component | perinuclear region of cytoplasm |
| GO_0055038 | Cellular component | recycling endosome membrane |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005794 | Cellular component | Golgi apparatus |
| GO_0005802 | Cellular component | trans-Golgi network |
| GO_0000139 | Cellular component | Golgi membrane |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005776 | Cellular component | autophagosome |
| GO_0005634 | Cellular component | nucleus |
| GO_0070530 | Molecular function | K63-linked polyubiquitin modification-dependent protein binding |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0030674 | Molecular function | protein-macromolecule adaptor activity |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0031593 | Molecular function | polyubiquitin modification-dependent protein binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | OPTN |
| Protein name | Optineurin Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP) |
| Synonyms | HIP7 GLC1E NRP FIP2 HYPL |
| Description | FUNCTION: Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8 . Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation . Plays a role in the activation of innate immune response during viral infection. Mechanistically, recruits TBK1 at the Golgi apparatus, promoting its trans-phosphorylation after RLR or TLR3 stimulation . In turn, activated TBK1 phosphorylates its downstream partner IRF3 to produce IFN-beta/IFNB1. Plays a neuroprotective role in the eye and optic nerve. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment . Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52. .; FUNCTION: (Microbial infection) May constitute a cellular target for various viruses, such as adenovirus E3 14.7 or Bluetongue virus, to inhibit innate immune response . During RNA virus infection, such as that of Sendai virus, negatively regulates the induction of IFNB1 . . FUNCTION: May act by regulating membrane trafficking and cellular morphogenesis. . FUNCTION: May act by regulating membrane trafficking and cellular morphogenesis. . FUNCTION: May act by regulating membrane trafficking and cellular morphogenesis. . FUNCTION: May act by regulating membrane trafficking and cellular morphogenesis. . |
| Accessions | ENST00000482140.5 Q96CV9 A0A0S2Z500 H7C1H4 A0A0S2Z5I6 ENST00000486862.1 ENST00000424614.1 ENST00000378757.6 [Q96CV9-1] ENST00000378747.8 [Q96CV9-1] X6RKL2 ENST00000378748.7 [Q96CV9-1] ENST00000378752.7 [Q96CV9-2] ENST00000430081.5 A0A087X2G2 ENST00000263036.9 [Q96CV9-1] ENST00000378764.6 [Q96CV9-2] A0A087WY28 |
