I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 7 studies | 24% ± 7% | |
| classical monocyte | 4 studies | 20% ± 4% | |
| macrophage | 3 studies | 17% ± 2% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 7 studies | 24% ± 7% | |
| classical monocyte | 4 studies | 20% ± 4% | |
| macrophage | 3 studies | 17% ± 2% |
Insufficient scRNA-seq data for expression of HLX at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 1065.85 | 225 / 226 | 95% | 3.39 | 387 / 406 |
| skin | 90% | 950.02 | 1636 / 1809 | 93% | 3.95 | 438 / 472 |
| lung | 100% | 2091.87 | 577 / 578 | 77% | 1.77 | 890 / 1155 |
| thymus | 98% | 879.38 | 642 / 653 | 78% | 2.22 | 474 / 605 |
| intestine | 99% | 2693.60 | 959 / 966 | 74% | 1.63 | 391 / 527 |
| breast | 100% | 1639.80 | 459 / 459 | 71% | 1.48 | 798 / 1118 |
| bladder | 100% | 959.81 | 21 / 21 | 69% | 1.62 | 350 / 504 |
| uterus | 83% | 744.69 | 141 / 170 | 69% | 2.96 | 317 / 459 |
| kidney | 82% | 512.58 | 73 / 89 | 68% | 3.60 | 613 / 901 |
| prostate | 84% | 609.84 | 206 / 245 | 64% | 1.22 | 323 / 502 |
| adrenal gland | 67% | 346.33 | 172 / 258 | 81% | 2.68 | 187 / 230 |
| esophagus | 78% | 622.04 | 1127 / 1445 | 59% | 1.02 | 108 / 183 |
| stomach | 55% | 310.43 | 198 / 359 | 75% | 1.60 | 214 / 286 |
| ovary | 58% | 291.52 | 105 / 180 | 71% | 1.47 | 307 / 430 |
| pancreas | 24% | 96.57 | 80 / 328 | 94% | 3.89 | 167 / 178 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 3.78 | 29 / 29 |
| spleen | 100% | 1484.23 | 241 / 241 | 0% | 0 | 0 / 0 |
| adipose | 100% | 2695.00 | 1202 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 98% | 4.89 | 78 / 80 |
| heart | 96% | 791.97 | 830 / 861 | 0% | 0 | 0 / 0 |
| blood vessel | 87% | 696.21 | 1162 / 1335 | 0% | 0 | 0 / 0 |
| peripheral blood | 80% | 2122.18 | 747 / 929 | 0% | 0 | 0 / 0 |
| muscle | 74% | 378.23 | 595 / 803 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 67% | 1.18 | 30 / 45 |
| brain | 3% | 12.01 | 89 / 2642 | 51% | 1.25 | 359 / 705 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0050673 | Biological process | epithelial cell proliferation |
| GO_0035265 | Biological process | organ growth |
| GO_0007519 | Biological process | skeletal muscle tissue development |
| GO_0045063 | Biological process | T-helper 1 cell differentiation |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0007165 | Biological process | signal transduction |
| GO_0045629 | Biological process | negative regulation of T-helper 2 cell differentiation |
| GO_0001889 | Biological process | liver development |
| GO_0045064 | Biological process | T-helper 2 cell differentiation |
| GO_0050679 | Biological process | positive regulation of epithelial cell proliferation |
| GO_0048557 | Biological process | embryonic digestive tract morphogenesis |
| GO_0045627 | Biological process | positive regulation of T-helper 1 cell differentiation |
| GO_0046622 | Biological process | positive regulation of organ growth |
| GO_0048484 | Biological process | enteric nervous system development |
| GO_0000785 | Cellular component | chromatin |
| GO_0005634 | Cellular component | nucleus |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_0043565 | Molecular function | sequence-specific DNA binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | HLX |
| Protein name | H2.0-like homeobox protein (Homeobox protein HB24) (Homeobox protein HLX1) H2.0 like homeobox |
| Synonyms | HLX1 |
| Description | FUNCTION: Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis (By similarity). . |
| Accessions | F8VWZ5 ENST00000427693.1 ENST00000366903.8 Q14774 |
