MST1R report

I. Expression across cell types

Insufficient scRNA-seq data for expression of MST1R at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MST1R at tissue level.

III. Associated gene sets

GO_0007169Biological processcell surface receptor protein tyrosine kinase signaling pathway
GO_0045087Biological processinnate immune response
GO_0007165Biological processsignal transduction
GO_0009615Biological processresponse to virus
GO_0007275Biological processmulticellular organism development
GO_0038145Biological processmacrophage colony-stimulating factor signaling pathway
GO_0043406Biological processpositive regulation of MAP kinase activity
GO_0033674Biological processpositive regulation of kinase activity
GO_0006909Biological processphagocytosis
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0007338Biological processsingle fertilization
GO_0016477Biological processcell migration
GO_0007399Biological processnervous system development
GO_0006952Biological processdefense response
GO_0043235Cellular componentreceptor complex
GO_0005886Cellular componentplasma membrane
GO_0005773Cellular componentvacuole
GO_0009986Cellular componentcell surface
GO_0001725Cellular componentstress fiber
GO_0019899Molecular functionenzyme binding
GO_0005011Molecular functionmacrophage colony-stimulating factor receptor activity
GO_0004714Molecular functiontransmembrane receptor protein tyrosine kinase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMST1R
Protein nameMacrophage stimulating 1 receptor
Macrophage-stimulating protein receptor (MSP receptor) (EC 2.7.10.1) (CDw136) (Protein-tyrosine kinase 8) (p185-Ron) (CD antigen CD136) [Cleaved into: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain]
SynonymsPTK8
RON
DescriptionFUNCTION: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Also plays a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand. .

AccessionsENST00000296474.8 [Q04912-1]
ENST00000621387.4 [Q04912-7]
Q04912
ENST00000440292.1
ENST00000344206.8 [Q04912-2]
ENST00000434765.5
H7C074
H7C3Z8
J3KQS7
ENST00000411578.6