ALK report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097009Biological processenergy homeostasis
GO_0045664Biological processregulation of neuron differentiation
GO_0060159Biological processregulation of dopamine receptor signaling pathway
GO_0021766Biological processhippocampus development
GO_0007169Biological processcell surface receptor protein tyrosine kinase signaling pathway
GO_0090648Biological processresponse to environmental enrichment
GO_0007165Biological processsignal transduction
GO_0007275Biological processmulticellular organism development
GO_0038083Biological processpeptidyl-tyrosine autophosphorylation
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0033674Biological processpositive regulation of kinase activity
GO_0042981Biological processregulation of apoptotic process
GO_1900006Biological processpositive regulation of dendrite development
GO_0036269Biological processswimming behavior
GO_0048666Biological processneuron development
GO_0050995Biological processnegative regulation of lipid catabolic process
GO_0030534Biological processadult behavior
GO_0016310Biological processphosphorylation
GO_0046777Biological processprotein autophosphorylation
GO_0042127Biological processregulation of cell population proliferation
GO_0043235Cellular componentreceptor complex
GO_0005886Cellular componentplasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0032991Cellular componentprotein-containing complex
GO_0008201Molecular functionheparin binding
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0042802Molecular functionidentical protein binding
GO_0004714Molecular functiontransmembrane receptor protein tyrosine kinase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0030298Molecular functionreceptor signaling protein tyrosine kinase activator activity

IV. Literature review

[source]
Gene nameALK
Protein nameAnaplastic lymphoma kinase
SEC31A/ALK fusion protein
Uncharacterized protein ALK
Tyrosine-protein kinase receptor (EC 2.7.10.1)
ALK receptor tyrosine kinase
ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)
SynonymsSTRN
fusion
SEC31A
DescriptionFUNCTION: Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system . Also acts as a key thinness protein involved in the resistance to weight gain: in hypothalamic neurons, controls energy expenditure acting as a negative regulator of white adipose tissue lipolysis and sympathetic tone to fine-tune energy homeostasis (By similarity). Following activation by ALKAL2 ligand at the cell surface, transduces an extracellular signal into an intracellular response . In contrast, ALKAL1 is not a potent physiological ligand for ALK . Ligand-binding to the extracellular domain induces tyrosine kinase activation, leading to activation of the mitogen-activated protein kinase (MAPK) pathway . Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif . Induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1 . ALK activation may also be regulated by pleiotrophin (PTN) and midkine (MDK) . PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation . MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction . Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase . Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK . .

AccessionsB2MXD8
B2MXE2
B6D4Y8
F0UY65
D1MAM2
B2MXE3
ENST00000618119.4
Q580I3
B2MXE1
B6D4Y3
ENST00000453137.1
A0A087WZL3
B2MXE7
B2MXD7
D1MAM0
B6D4Y5
B2MXE0
B6D4Y1
D1MAM1
B6D4Y7
ENST00000431873.6
Q9UM73
D1MAM5
D1MAM3
B2MXD9
B2MXE5
B2MXE6
F0UY66
ENST00000389048.8
A0A097F6U9
B6D4Y6
D1MAM4
B6D4Y2
ENST00000642122.1
B2MXE4
H7BZ33
A0A0K2YUJ3
E7EPW7
A0A024A2P5