PPP2R5C | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	45 studies	41% ± 17%	Explore
CD8-positive, alpha-beta T cell	36 studies	41% ± 16%	Explore
T cell	35 studies	41% ± 12%	Explore
CD4-positive, alpha-beta T cell	32 studies	41% ± 16%	Explore
B cell	23 studies	30% ± 10%	Explore
mature NK T cell	23 studies	46% ± 15%	Explore
endothelial cell	22 studies	30% ± 13%	Explore
regulatory T cell	22 studies	37% ± 11%	Explore
macrophage	21 studies	28% ± 15%	Explore
gamma-delta T cell	19 studies	48% ± 17%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	36% ± 17%	Explore
mucosal invariant T cell	16 studies	47% ± 15%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	49% ± 17%	Explore
CD8-positive, alpha-beta memory T cell	14 studies	48% ± 17%	Explore
effector memory CD8-positive, alpha-beta T cell	13 studies	57% ± 23%	Explore
ciliated cell	13 studies	31% ± 12%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	33% ± 15%	Explore
CD16-negative, CD56-bright natural killer cell, human	13 studies	36% ± 14%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	40% ± 13%	Explore
astrocyte	12 studies	38% ± 15%	Explore
endothelial cell of lymphatic vessel	11 studies	27% ± 14%	Explore
microglial cell	11 studies	39% ± 12%	Explore
fibroblast	11 studies	25% ± 8%	Explore
oligodendrocyte	11 studies	34% ± 12%	Explore
mast cell	10 studies	25% ± 10%	Explore
classical monocyte	10 studies	27% ± 13%	Explore
memory B cell	10 studies	22% ± 5%	Explore
glutamatergic neuron	10 studies	51% ± 25%	Explore
oligodendrocyte precursor cell	10 studies	36% ± 15%	Explore
monocyte	9 studies	29% ± 6%	Explore
plasmacytoid dendritic cell	9 studies	29% ± 9%	Explore
naive B cell	9 studies	23% ± 4%	Explore
T follicular helper cell	9 studies	47% ± 16%	Explore
GABAergic neuron	9 studies	43% ± 24%	Explore
type I pneumocyte	8 studies	32% ± 8%	Explore
leukocyte	8 studies	47% ± 18%	Explore
non-classical monocyte	8 studies	31% ± 15%	Explore
myeloid cell	8 studies	31% ± 8%	Explore
plasma cell	8 studies	35% ± 11%	Explore
epithelial cell	8 studies	43% ± 20%	Explore
basal cell	8 studies	33% ± 18%	Explore
type II pneumocyte	7 studies	33% ± 10%	Explore
CD4-positive helper T cell	7 studies	42% ± 19%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	42% ± 16%	Explore
neuron	7 studies	38% ± 16%	Explore
dendritic cell	7 studies	40% ± 19%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	6 studies	47% ± 15%	Explore
interneuron	6 studies	46% ± 23%	Explore
club cell	6 studies	27% ± 7%	Explore
adipocyte	6 studies	24% ± 5%	Explore
innate lymphoid cell	6 studies	26% ± 9%	Explore
smooth muscle cell	6 studies	21% ± 4%	Explore
pericyte	6 studies	26% ± 10%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	40% ± 13%	Explore
exhausted T cell	5 studies	43% ± 25%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	44% ± 13%	Explore
conventional dendritic cell	5 studies	30% ± 16%	Explore
lymphocyte	5 studies	54% ± 24%	Explore
retinal cone cell	5 studies	27% ± 10%	Explore
cardiac muscle cell	5 studies	39% ± 11%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	55% ± 18%	Explore
abnormal cell	5 studies	23% ± 8%	Explore
goblet cell	5 studies	37% ± 17%	Explore
plasmablast	4 studies	39% ± 20%	Explore
granule cell	4 studies	29% ± 8%	Explore
mononuclear phagocyte	4 studies	25% ± 7%	Explore
respiratory goblet cell	4 studies	27% ± 12%	Explore
hepatocyte	4 studies	38% ± 13%	Explore
double negative thymocyte	4 studies	51% ± 10%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	30% ± 10%	Explore
hematopoietic precursor cell	3 studies	27% ± 11%	Explore
IgG plasma cell	3 studies	19% ± 5%	Explore
GABAergic interneuron	3 studies	32% ± 3%	Explore
retinal ganglion cell	3 studies	27% ± 2%	Explore
squamous epithelial cell	3 studies	38% ± 26%	Explore
retinal rod cell	3 studies	21% ± 4%	Explore
tissue-resident macrophage	3 studies	23% ± 7%	Explore
vein endothelial cell	3 studies	33% ± 22%	Explore
intraepithelial lymphocyte	3 studies	30% ± 11%	Explore
Mueller cell	3 studies	18% ± 3%	Explore
endothelial cell of vascular tree	3 studies	27% ± 16%	Explore
connective tissue cell	3 studies	20% ± 1%	Explore
ependymal cell	3 studies	33% ± 18%	Explore
brush cell	3 studies	37% ± 14%	Explore
enteroendocrine cell	3 studies	25% ± 5%	Explore
myofibroblast cell	3 studies	23% ± 6%	Explore
alveolar macrophage	3 studies	32% ± 8%	Explore
group 3 innate lymphoid cell	3 studies	28% ± 5%	Explore
transit amplifying cell	3 studies	38% ± 26%	Explore
T-helper 17 cell	3 studies	56% ± 8%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	40% ± 7%	Explore
mucus secreting cell	3 studies	29% ± 4%	Explore
erythrocyte	3 studies	24% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	17 studies	37% ± 20%	Explore
peripheral blood	16 studies	35% ± 16%	Explore
lung	14 studies	30% ± 8%	Explore
intestine	6 studies	25% ± 6%	Explore
liver	6 studies	35% ± 11%	Explore
eye	5 studies	28% ± 15%	Explore
heart	4 studies	28% ± 7%	Explore
bone marrow	3 studies	29% ± 7%	Explore
uterus	3 studies	22% ± 8%	Explore
kidney	3 studies	22% ± 2%	Explore
breast	3 studies	18% ± 3%	Explore
adipose	3 studies	24% ± 2%	Explore
lymph node	3 studies	29% ± 10%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	6957.00	1445 / 1445	100%	28.72	183 / 183
lung	100%	7064.19	578 / 578	100%	31.80	1155 / 1155
ovary	100%	5252.53	180 / 180	100%	22.43	430 / 430
brain	100%	7011.54	2641 / 2642	100%	36.86	705 / 705
breast	100%	5960.49	459 / 459	100%	31.31	1117 / 1118
thymus	100%	6175.31	653 / 653	100%	31.63	604 / 605
intestine	100%	7936.11	966 / 966	100%	30.17	526 / 527
prostate	100%	5298.49	245 / 245	100%	23.70	501 / 502
uterus	100%	5865.34	170 / 170	100%	26.51	458 / 459
stomach	100%	4872.14	359 / 359	100%	26.03	285 / 286
bladder	100%	6687.43	21 / 21	100%	25.31	502 / 504
skin	100%	6244.96	1809 / 1809	99%	27.23	469 / 472
kidney	100%	4511.83	89 / 89	99%	18.75	890 / 901
pancreas	99%	3066.30	325 / 328	99%	25.60	177 / 178
liver	100%	2876.09	226 / 226	99%	14.48	400 / 406
adrenal gland	100%	6119.19	258 / 258	98%	29.78	225 / 230
adipose	100%	6004.86	1204 / 1204	0%	0	0 / 0
blood vessel	100%	7185.18	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	42.61	29 / 29
muscle	100%	4083.13	803 / 803	0%	0	0 / 0
spleen	100%	7062.37	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	24.40	45 / 45
ureter	0%	0	0 / 0	100%	10.60	1 / 1
peripheral blood	99%	6429.75	917 / 929	0%	0	0 / 0
heart	98%	5601.97	841 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	98%	19.87	78 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007165	Biological process	signal transduction
GO_0008285	Biological process	negative regulation of cell population proliferation
GO_0006470	Biological process	protein dephosphorylation
GO_0043161	Biological process	proteasome-mediated ubiquitin-dependent protein catabolic process
GO_0000775	Cellular component	chromosome, centromeric region
GO_0000159	Cellular component	protein phosphatase type 2A complex
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005794	Cellular component	Golgi apparatus
GO_0005634	Cellular component	nucleus
GO_0072542	Molecular function	protein phosphatase activator activity
GO_0019888	Molecular function	protein phosphatase regulator activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PPP2R5C
Protein name	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PP2A B subunit isoform B'-gamma) (PP2A B subunit isoform B56-gamma) (PP2A B subunit isoform PR61-gamma) (PP2A B subunit isoform R5-gamma) (Renal carcinoma antigen NY-REN-29) Protein phosphatase 2 regulatory subunit B'gamma
Synonyms	KIAA0044
Description	FUNCTION: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation. . FUNCTION: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. . FUNCTION: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. .
Accessions	ENST00000694906.1 H0YJU0 H0YK25 ENST00000556946.1 ENST00000557621.5 ENST00000554442.5 ENST00000556260.6 H0YJ49 A0A8Q3WKR3 Q96B13 H0YJ35 G3V2U3 ENST00000553554.1 ENST00000328724.9 [Q13362-4] ENST00000334743.9 [Q13362-1] H0YNJ3 ENST00000557714.1 ENST00000561006.5 Q13362 H0YN84 ENST00000557534.1 ENST00000555237.5 H0YK26 H0YJ12 ENST00000557716.2 H0YJZ3 G3V292 ENST00000553890.1 G3V5T2 H0YN58 ENST00000556307.5 ENST00000557071.1 ENST00000557095.5 ENST00000554137.5 ENST00000422945.6 [Q13362-5] ENST00000350249.7 [Q13362-3] H0YNR8 ENST00000445439.7 [Q13362-2]

PPP2R5C report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review