LILRB2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
classical monocyte	26 studies	45% ± 13%	Explore
macrophage	25 studies	27% ± 10%	Explore
non-classical monocyte	25 studies	74% ± 14%	Explore
monocyte	22 studies	37% ± 12%	Explore
conventional dendritic cell	10 studies	29% ± 11%	Explore
dendritic cell	10 studies	25% ± 12%	Explore
plasmacytoid dendritic cell	6 studies	16% ± 2%	Explore
myeloid cell	6 studies	31% ± 13%	Explore
neutrophil	5 studies	26% ± 8%	Explore
intermediate monocyte	5 studies	62% ± 24%	Explore
mononuclear phagocyte	4 studies	33% ± 11%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	8 studies	22% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	3349.61	578 / 578	93%	10.15	1072 / 1155
breast	76%	416.10	350 / 459	88%	6.88	985 / 1118
intestine	87%	466.85	839 / 966	76%	5.99	401 / 527
kidney	66%	360.67	59 / 89	87%	10.00	785 / 901
bladder	81%	490.33	17 / 21	67%	6.91	337 / 504
adrenal gland	92%	502.52	238 / 258	50%	2.59	115 / 230
esophagus	58%	266.15	840 / 1445	78%	4.99	142 / 183
uterus	59%	221.99	100 / 170	76%	5.87	348 / 459
liver	66%	403.37	150 / 226	65%	3.62	263 / 406
stomach	48%	269.13	174 / 359	82%	7.00	235 / 286
prostate	70%	335.59	171 / 245	53%	2.00	267 / 502
thymus	57%	207.80	375 / 653	59%	2.83	356 / 605
ovary	30%	103.51	54 / 180	75%	5.11	321 / 430
pancreas	22%	95.26	73 / 328	82%	7.00	146 / 178
spleen	100%	9930.89	241 / 241	0%	0	0 / 0
adipose	98%	1038.56	1174 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	36.30	28 / 29
skin	11%	33.22	205 / 1809	84%	11.82	396 / 472
tonsil	0%	0	0 / 0	89%	8.76	40 / 45
peripheral blood	83%	13101.82	775 / 929	0%	0	0 / 0
blood vessel	70%	494.85	932 / 1335	0%	0	0 / 0
brain	11%	36.02	295 / 2642	52%	3.31	366 / 705
heart	63%	283.76	542 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	26%	1.34	21 / 80
muscle	7%	19.34	60 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0002578	Biological process	negative regulation of antigen processing and presentation
GO_0042102	Biological process	positive regulation of T cell proliferation
GO_0002666	Biological process	positive regulation of T cell tolerance induction
GO_2001198	Biological process	regulation of dendritic cell differentiation
GO_0032755	Biological process	positive regulation of interleukin-6 production
GO_1900271	Biological process	regulation of long-term synaptic potentiation
GO_1905875	Biological process	negative regulation of postsynaptic density organization
GO_0007611	Biological process	learning or memory
GO_0051926	Biological process	negative regulation of calcium ion transport
GO_0007165	Biological process	signal transduction
GO_1900454	Biological process	positive regulation of long-term synaptic depression
GO_0034113	Biological process	heterotypic cell-cell adhesion
GO_0006968	Biological process	cellular defense response
GO_0002767	Biological process	immune response-inhibiting cell surface receptor signaling pathway
GO_2000524	Biological process	negative regulation of T cell costimulation
GO_0007267	Biological process	cell-cell signaling
GO_0140105	Biological process	interleukin-10-mediated signaling pathway
GO_0006955	Biological process	immune response
GO_0002250	Biological process	adaptive immune response
GO_0051248	Biological process	negative regulation of protein metabolic process
GO_0002645	Biological process	positive regulation of tolerance induction
GO_0042130	Biological process	negative regulation of T cell proliferation
GO_0002764	Biological process	immune response-regulating signaling pathway
GO_0071222	Biological process	cellular response to lipopolysaccharide
GO_0045591	Biological process	positive regulation of regulatory T cell differentiation
GO_0035307	Biological process	positive regulation of protein dephosphorylation
GO_0007166	Biological process	cell surface receptor signaling pathway
GO_0002774	Biological process	Fc receptor mediated inhibitory signaling pathway
GO_0005615	Cellular component	extracellular space
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0009986	Cellular component	cell surface
GO_0070821	Cellular component	tertiary granule membrane
GO_0101003	Cellular component	ficolin-1-rich granule membrane
GO_0005737	Cellular component	cytoplasm
GO_0042803	Molecular function	protein homodimerization activity
GO_0044877	Molecular function	protein-containing complex binding
GO_0032396	Molecular function	inhibitory MHC class I receptor activity
GO_0001540	Molecular function	amyloid-beta binding
GO_0023029	Molecular function	MHC class Ib protein binding
GO_0042288	Molecular function	MHC class I protein binding
GO_0008157	Molecular function	protein phosphatase 1 binding
GO_0023025	Molecular function	MHC class Ib protein complex binding
GO_0050839	Molecular function	cell adhesion molecule binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	LILRB2
Protein name	Leukocyte immunoglobulin-like receptor subfamily B member 2 Leukocyte immunoglobulin-like receptor subfamily B member 2 (LIR-2) (Leukocyte immunoglobulin-like receptor 2) (CD85 antigen-like family member D) (Immunoglobulin-like transcript 4) (ILT-4) (Monocyte/macrophage immunoglobulin-like receptor 10) (MIR-10) (CD antigen CD85d) Leukocyte immunoglobulin like receptor B2 (Leukocyte immunoglobulin-like receptor subfamily B member 2)
Synonyms	MIR10 LIR2 ILT4
Description	FUNCTION: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles . Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance . Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions . .
Accessions	ENST00000434421.5 [Q8N423-4] Q8N423 ENST00000619122.3 ENST00000614965.4 ENST00000620441.4 ENST00000616216.1 ENST00000391748.5 [Q8N423-2] ENST00000621989.4 A0A140JSW6 ENST00000617886.4 ENST00000610367.4 A0A0G2JMW1 ENST00000613032.4 ENST00000614225.4 A0A0G2JNE7 ENST00000391749.4 [Q8N423-1] A0A0G2JQ48 ENST00000618392.4 A0A0G2JNH0 A0A0G2JN35 ENST00000620625.4 A0A0G2JLS7 ENST00000613437.1 ENST00000314446.10 [Q8N423-2] ENST00000617643.4 A0A0G2JNT8 ENST00000391746.5 [Q8N423-3] ENST00000621522.4 A0A0G2JPH5 ENST00000621542.1 ENST00000617081.4 ENST00000617341.4 H7C0C3 ENST00000610886.4 ENST00000621020.4 A0A0G2JM05 ENST00000618705.2 ENST00000455108.5 ENST00000613933.4 A0A0G2JNQ7 ENST00000615641.4

LILRB2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review