IL1RAPL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1905606Biological processregulation of presynapse assembly
GO_0061003Biological processpositive regulation of dendritic spine morphogenesis
GO_0007165Biological processsignal transduction
GO_0099560Biological processsynaptic membrane adhesion
GO_0030182Biological processneuron differentiation
GO_0099545Biological processtrans-synaptic signaling by trans-synaptic complex
GO_0010975Biological processregulation of neuron projection development
GO_0045920Biological processnegative regulation of exocytosis
GO_0051965Biological processpositive regulation of synapse assembly
GO_0097105Biological processpresynaptic membrane assembly
GO_0099175Biological processregulation of postsynapse organization
GO_0098978Cellular componentglutamatergic synapse
GO_0005886Cellular componentplasma membrane
GO_0030425Cellular componentdendrite
GO_0009986Cellular componentcell surface
GO_0005737Cellular componentcytoplasm
GO_0045211Cellular componentpostsynaptic membrane
GO_0030424Cellular componentaxon
GO_0003953Molecular functionNAD+ nucleosidase activity
GO_0019966Molecular functioninterleukin-1 binding
GO_0005102Molecular functionsignaling receptor binding
GO_0005515Molecular functionprotein binding
GO_0061809Molecular functionNAD+ nucleotidase, cyclic ADP-ribose generating

IV. Literature review

[source]
Gene nameIL1RAPL1
Protein nameInterleukin-1 receptor accessory protein-like 1 (X-linked interleukin-1 receptor accessory protein-like 1)
Interleukin-1 receptor accessory protein-like 1 (IL-1-RAPL-1) (IL-1RAPL-1) (IL1RAPL-1) (EC 3.2.2.6) (Oligophrenin-4) (Three immunoglobulin domain-containing IL-1 receptor-related 2) (TIGIRR-2) (X-linked interleukin-1 receptor accessory protein-like 1)
Interleukin 1 receptor accessory protein-like 1
SynonymsOPHN4
DescriptionFUNCTION: May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel . May activate the MAP kinase JNK . Plays a role in neurite outgrowth (By similarity). During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity). .

AccessionsX5DNQ7
Q9NZN1
Q7Z2K4
A0A346RP49
Q7Z2H0
ENST00000378993.6 [Q9NZN1-1]