XRCC6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032508Biological processDNA duplex unwinding
GO_0006303Biological processdouble-strand break repair via nonhomologous end joining
GO_0045087Biological processinnate immune response
GO_0071480Biological processcellular response to gamma radiation
GO_0097680Biological processdouble-strand break repair via classical nonhomologous end joining
GO_0045860Biological processpositive regulation of protein kinase activity
GO_0048660Biological processregulation of smooth muscle cell proliferation
GO_0000725Biological processrecombinational repair
GO_0071475Biological processcellular hyperosmotic salinity response
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0071481Biological processcellular response to X-ray
GO_0000723Biological processtelomere maintenance
GO_0045621Biological processpositive regulation of lymphocyte differentiation
GO_0002218Biological processactivation of innate immune response
GO_0006266Biological processDNA ligation
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005730Cellular componentnucleolus
GO_0032993Cellular componentprotein-DNA complex
GO_0005576Cellular componentextracellular region
GO_0016020Cellular componentmembrane
GO_0000783Cellular componentnuclear telomere cap complex
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0034774Cellular componentsecretory granule lumen
GO_0005958Cellular componentDNA-dependent protein kinase-DNA ligase 4 complex
GO_1904813Cellular componentficolin-1-rich granule lumen
GO_0005829Cellular componentcytosol
GO_0070418Cellular componentDNA-dependent protein kinase complex
GO_0043564Cellular componentKu70:Ku80 complex
GO_0000781Cellular componentchromosome, telomeric region
GO_0005667Cellular componenttranscription regulator complex
GO_0070419Cellular componentnonhomologous end joining complex
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0051575Molecular function5'-deoxyribose-5-phosphate lyase activity
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0044877Molecular functionprotein-containing complex binding
GO_0003690Molecular functiondouble-stranded DNA binding
GO_0042162Molecular functiontelomeric DNA binding
GO_0045027Molecular functionDNA end binding
GO_0097110Molecular functionscaffold protein binding
GO_0003691Molecular functiondouble-stranded telomeric DNA binding
GO_0003678Molecular functionDNA helicase activity
GO_0016887Molecular functionATP hydrolysis activity
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding
GO_0030332Molecular functioncyclin binding
GO_0008094Molecular functionATP-dependent activity, acting on DNA
GO_0005515Molecular functionprotein binding
GO_0003684Molecular functiondamaged DNA binding

IV. Literature review

[source]
Gene nameXRCC6
Protein nameX-ray repair cross complementing 6
X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6)
SynonymsG22P1
DescriptionFUNCTION: Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA . Required for double-strand break repair and V(D)J recombination . Also has a role in chromosome translocation . Has a role in chromosome translocation . The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner . It works in the 3'-5' direction . During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection . Binding to DNA may be mediated by XRCC6 . The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold . The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together . The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step . Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks . 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined . The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription . In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression . Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway . .

AccessionsB1AHC9
P12956
ENST00000359308.8 [P12956-1]
ENST00000405878.5 [P12956-1]
ENST00000405506.2
ENST00000428575.6
ENST00000360079.8 [P12956-1]
ENST00000402580.7 [P12956-2]