DDX17 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0002376Biological processimmune system process
GO_0001837Biological processepithelial to mesenchymal transition
GO_0006396Biological processRNA processing
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0051607Biological processdefense response to virus
GO_2001014Biological processregulation of skeletal muscle cell differentiation
GO_0000381Biological processregulation of alternative mRNA splicing, via spliceosome
GO_0000380Biological processalternative mRNA splicing, via spliceosome
GO_0031047Biological processregulatory ncRNA-mediated gene silencing
GO_0045445Biological processmyoblast differentiation
GO_0030521Biological processandrogen receptor signaling pathway
GO_0006364Biological processrRNA processing
GO_0030520Biological processestrogen receptor signaling pathway
GO_0010586Biological processmiRNA metabolic process
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005730Cellular componentnucleolus
GO_0016020Cellular componentmembrane
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_1990904Cellular componentribonucleoprotein complex
GO_0005634Cellular componentnucleus
GO_0003724Molecular functionRNA helicase activity
GO_0043021Molecular functionribonucleoprotein complex binding
GO_0008186Molecular functionATP-dependent activity, acting on RNA
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0003730Molecular functionmRNA 3'-UTR binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameDDX17
Protein nameRNA helicase (EC 3.6.4.13)
Probable ATP-dependent RNA helicase DDX17 (EC 3.6.4.13) (DEAD box protein 17) (DEAD box protein p72) (DEAD box protein p82) (RNA-dependent helicase p72)
Synonyms
DescriptionFUNCTION: As an RNA helicase, unwinds RNA and alters RNA structures through ATP binding and hydrolysis. Involved in multiple cellular processes, including pre-mRNA splicing, alternative splicing, ribosomal RNA processing and miRNA processing, as well as transcription regulation. Regulates the alternative splicing of exons exhibiting specific features . For instance, promotes the inclusion of AC-rich alternative exons in CD44 transcripts . This function requires the RNA helicase activity . Affects NFAT5 and histone macro-H2A.1/MACROH2A1 alternative splicing in a CDK9-dependent manner . In NFAT5, promotes the introduction of alternative exon 4, which contains 2 stop codons and may target NFAT5 exon 4-containing transcripts to nonsense-mediated mRNA decay, leading to the down-regulation of NFAT5 protein . Affects splicing of mediators of steroid hormone signaling pathway, including kinases that phosphorylates ESR1, such as CDK2, MAPK1 and GSK3B, and transcriptional regulators, such as CREBBP, MED1, NCOR1 and NCOR2. By affecting GSK3B splicing, participates in ESR1 and AR stabilization . In myoblasts and epithelial cells, cooperates with HNRNPH1 to control the splicing of specific subsets of exons . In addition to binding mature mRNAs, also interacts with certain pri-microRNAs, including MIR663/miR-663a, MIR99B/miR-99b, and MIR6087/miR-6087 . Binds pri-microRNAs on the 3' segment flanking the stem loop via the 5'-[ACG]CAUC[ACU]-3' consensus sequence . Required for the production of subsets of microRNAs, including MIR21 and MIR125B1 . May be involved not only in microRNA primary transcript processing, but also stabilization (By similarity). Participates in MYC down-regulation at high cell density through the production of MYC-targeting microRNAs . Along with DDX5, may be involved in the processing of the 32S intermediate into the mature 28S ribosomal RNA . Promoter-specific transcription regulator, functioning as a coactivator or corepressor depending on the context of the promoter and the transcriptional complex in which it exists . Enhances NFAT5 transcriptional activity . Synergizes with TP53 in the activation of the MDM2 promoter; this activity requires acetylation on lysine residues . May also coactivate MDM2 transcription through a TP53-independent pathway . Coactivates MMP7 transcription . Along with CTNNB1, coactivates MYC, JUN, FOSL1 and cyclin D1/CCND1 transcription . Alone or in combination with DDX5 and/or SRA1 non-coding RNA, plays a critical role in promoting the assembly of proteins required for the formation of the transcription initiation complex and chromatin remodeling leading to coactivation of MYOD1-dependent transcription. This helicase-independent activity is required for skeletal muscle cells to properly differentiate into myotubes . During epithelial-to-mesenchymal transition, coregulates SMAD-dependent transcriptional activity, directly controlling key effectors of differentiation, including miRNAs which in turn directly repress its expression . Plays a role in estrogen and testosterone signaling pathway at several levels. Mediates the use of alternative promoters in estrogen-responsive genes and regulates transcription and splicing of a large number of steroid hormone target genes . Contrary to splicing regulation activity, transcriptional coregulation of the estrogen receptor ESR1 is helicase-independent . Plays a role in innate immunity. Specifically restricts bunyavirus infection, including Rift Valley fever virus (RVFV) or La Crosse virus (LACV), but not vesicular stomatitis virus (VSV), in an interferon- and DROSHA-independent manner . Binds to RVFV RNA, likely via structured viral RNA elements . Promotes mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1, in an ATPase-dependent manner . .

AccessionsENST00000396821.8
ENST00000475004.6
A0A1X7SBZ2
Q92841
A0A0U1RQJ0
ENST00000403230
ENST00000403230.3 [Q92841-4]
A0A5H1ZRQ2