SUB1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	43 studies	56% ± 18%	Explore
natural killer cell	42 studies	63% ± 18%	Explore
endothelial cell	40 studies	52% ± 21%	Explore
fibroblast	39 studies	56% ± 20%	Explore
T cell	38 studies	58% ± 23%	Explore
macrophage	38 studies	54% ± 20%	Explore
CD8-positive, alpha-beta T cell	36 studies	65% ± 19%	Explore
CD4-positive, alpha-beta T cell	32 studies	67% ± 17%	Explore
pericyte	31 studies	52% ± 19%	Explore
conventional dendritic cell	30 studies	78% ± 15%	Explore
dendritic cell	28 studies	67% ± 23%	Explore
plasma cell	28 studies	73% ± 21%	Explore
classical monocyte	27 studies	63% ± 15%	Explore
regulatory T cell	27 studies	70% ± 14%	Explore
smooth muscle cell	26 studies	55% ± 20%	Explore
plasmacytoid dendritic cell	26 studies	80% ± 15%	Explore
non-classical monocyte	24 studies	64% ± 16%	Explore
monocyte	23 studies	61% ± 22%	Explore
mast cell	22 studies	54% ± 21%	Explore
mature NK T cell	22 studies	57% ± 18%	Explore
epithelial cell	22 studies	60% ± 22%	Explore
endothelial cell of lymphatic vessel	20 studies	54% ± 18%	Explore
memory B cell	20 studies	59% ± 12%	Explore
naive B cell	20 studies	49% ± 12%	Explore
basal cell	20 studies	58% ± 19%	Explore
gamma-delta T cell	19 studies	60% ± 17%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	18 studies	53% ± 17%	Explore
connective tissue cell	18 studies	63% ± 22%	Explore
mucosal invariant T cell	16 studies	51% ± 15%	Explore
ciliated cell	16 studies	57% ± 21%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	65% ± 15%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	58% ± 17%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	61% ± 16%	Explore
capillary endothelial cell	14 studies	42% ± 18%	Explore
myofibroblast cell	14 studies	55% ± 22%	Explore
myeloid cell	14 studies	64% ± 23%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	58% ± 23%	Explore
plasmablast	12 studies	86% ± 12%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	63% ± 19%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	65% ± 18%	Explore
neutrophil	12 studies	50% ± 27%	Explore
secretory cell	12 studies	57% ± 21%	Explore
endothelial cell of artery	12 studies	53% ± 16%	Explore
vein endothelial cell	12 studies	52% ± 18%	Explore
endothelial cell of vascular tree	12 studies	58% ± 17%	Explore
innate lymphoid cell	11 studies	56% ± 19%	Explore
leukocyte	11 studies	58% ± 24%	Explore
type I pneumocyte	10 studies	39% ± 19%	Explore
progenitor cell	10 studies	66% ± 20%	Explore
abnormal cell	10 studies	57% ± 23%	Explore
mesothelial cell	10 studies	70% ± 21%	Explore
IgG plasma cell	10 studies	63% ± 24%	Explore
astrocyte	10 studies	30% ± 14%	Explore
oligodendrocyte precursor cell	10 studies	37% ± 20%	Explore
type II pneumocyte	9 studies	43% ± 24%	Explore
platelet	9 studies	35% ± 11%	Explore
neuron	9 studies	53% ± 23%	Explore
goblet cell	9 studies	46% ± 19%	Explore
IgA plasma cell	9 studies	65% ± 24%	Explore
T follicular helper cell	9 studies	61% ± 14%	Explore
glutamatergic neuron	9 studies	42% ± 21%	Explore
adipocyte	9 studies	23% ± 7%	Explore
club cell	8 studies	44% ± 18%	Explore
hematopoietic stem cell	8 studies	65% ± 18%	Explore
GABAergic neuron	8 studies	38% ± 17%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	78% ± 12%	Explore
epithelial cell of proximal tubule	7 studies	52% ± 14%	Explore
precursor B cell	7 studies	70% ± 22%	Explore
immature B cell	7 studies	65% ± 22%	Explore
microglial cell	7 studies	29% ± 16%	Explore
erythrocyte	7 studies	49% ± 23%	Explore
oligodendrocyte	7 studies	24% ± 8%	Explore
alveolar macrophage	6 studies	43% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	6 studies	48% ± 21%	Explore
hematopoietic precursor cell	6 studies	66% ± 24%	Explore
ionocyte	6 studies	50% ± 14%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	79% ± 13%	Explore
mononuclear phagocyte	6 studies	65% ± 25%	Explore
kidney loop of Henle epithelial cell	6 studies	61% ± 9%	Explore
renal alpha-intercalated cell	6 studies	71% ± 11%	Explore
enterocyte	6 studies	48% ± 11%	Explore
transit amplifying cell	6 studies	38% ± 21%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	74% ± 15%	Explore
CD4-positive helper T cell	5 studies	53% ± 17%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	51% ± 16%	Explore
exhausted T cell	5 studies	81% ± 12%	Explore
respiratory goblet cell	5 studies	37% ± 25%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	69% ± 13%	Explore
megakaryocyte	5 studies	69% ± 18%	Explore
enteroendocrine cell	5 studies	61% ± 25%	Explore
erythroblast	5 studies	65% ± 27%	Explore
intestinal crypt stem cell	5 studies	46% ± 18%	Explore
lymphocyte	5 studies	55% ± 26%	Explore
brush cell	5 studies	39% ± 23%	Explore
neuroendocrine cell	5 studies	78% ± 17%	Explore
T-helper 17 cell	5 studies	73% ± 15%	Explore
double negative thymocyte	5 studies	79% ± 10%	Explore
intermediate monocyte	5 studies	75% ± 13%	Explore
granulocyte	5 studies	71% ± 16%	Explore
interneuron	5 studies	42% ± 17%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	57% ± 30%	Explore
pancreatic A cell	4 studies	79% ± 10%	Explore
type B pancreatic cell	4 studies	70% ± 14%	Explore
glomerular endothelial cell	4 studies	44% ± 13%	Explore
OFF-bipolar cell	4 studies	39% ± 16%	Explore
ON-bipolar cell	4 studies	33% ± 19%	Explore
retinal ganglion cell	4 studies	63% ± 26%	Explore
pro-B cell	4 studies	75% ± 5%	Explore
amacrine cell	4 studies	51% ± 22%	Explore
retina horizontal cell	4 studies	38% ± 19%	Explore
retinal rod cell	4 studies	34% ± 15%	Explore
adventitial cell	4 studies	39% ± 11%	Explore
mucus secreting cell	4 studies	40% ± 12%	Explore
acinar cell	4 studies	43% ± 12%	Explore
muscle cell	4 studies	42% ± 17%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	81% ± 4%	Explore
IgM plasma cell	4 studies	63% ± 21%	Explore
hepatocyte	4 studies	54% ± 25%	Explore
group 3 innate lymphoid cell	4 studies	66% ± 13%	Explore
T-helper 1 cell	4 studies	75% ± 12%	Explore
deuterosomal cell	3 studies	42% ± 3%	Explore
duct epithelial cell	3 studies	35% ± 1%	Explore
precursor cell	3 studies	67% ± 15%	Explore
pancreatic D cell	3 studies	72% ± 17%	Explore
monocyte-derived dendritic cell	3 studies	78% ± 25%	Explore
podocyte	3 studies	74% ± 10%	Explore
neural crest cell	3 studies	76% ± 5%	Explore
retinal bipolar neuron	3 studies	56% ± 23%	Explore
GABAergic amacrine cell	3 studies	28% ± 13%	Explore
glycinergic amacrine cell	3 studies	23% ± 10%	Explore
renal principal cell	3 studies	59% ± 4%	Explore
thymocyte	3 studies	64% ± 24%	Explore
extravillous trophoblast	3 studies	80% ± 10%	Explore
placental villous trophoblast	3 studies	83% ± 6%	Explore
retinal cone cell	3 studies	61% ± 19%	Explore
retinal pigment epithelial cell	3 studies	43% ± 27%	Explore
serous secreting cell	3 studies	52% ± 7%	Explore
tissue-resident macrophage	3 studies	46% ± 21%	Explore
intraepithelial lymphocyte	3 studies	59% ± 24%	Explore
Mueller cell	3 studies	47% ± 9%	Explore
rod bipolar cell	3 studies	40% ± 14%	Explore
cardiac muscle cell	3 studies	28% ± 7%	Explore
germinal center B cell	3 studies	35% ± 7%	Explore
myoepithelial cell	3 studies	66% ± 15%	Explore
inflammatory macrophage	3 studies	43% ± 16%	Explore
luminal cell of prostate epithelium	3 studies	67% ± 8%	Explore
pancreatic ductal cell	3 studies	84% ± 4%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	87% ± 8%	Explore
glial cell	3 studies	54% ± 26%	Explore
melanocyte	3 studies	28% ± 9%	Explore
keratinocyte	3 studies	65% ± 8%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	67% ± 3%	Explore
double-positive, alpha-beta thymocyte	3 studies	77% ± 5%	Explore
progenitor cell of mammary luminal epithelium	3 studies	68% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	20 studies	62% ± 13%	Explore
lung	19 studies	56% ± 18%	Explore
brain	15 studies	35% ± 15%	Explore
intestine	12 studies	54% ± 23%	Explore
kidney	9 studies	58% ± 15%	Explore
eye	9 studies	38% ± 16%	Explore
bone marrow	6 studies	58% ± 12%	Explore
lymph node	6 studies	60% ± 13%	Explore
liver	6 studies	58% ± 18%	Explore
pancreas	5 studies	65% ± 20%	Explore
uterus	5 studies	63% ± 17%	Explore
placenta	4 studies	67% ± 22%	Explore
prostate	4 studies	65% ± 13%	Explore
breast	4 studies	67% ± 3%	Explore
heart	3 studies	32% ± 12%	Explore
adrenal gland	3 studies	58% ± 15%	Explore
esophagus	3 studies	62% ± 26%	Explore
skin	3 studies	52% ± 11%	Explore
thymus	3 studies	75% ± 22%	Explore
adipose	3 studies	29% ± 13%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	4730.06	1445 / 1445	100%	50.23	183 / 183
liver	100%	3144.62	226 / 226	100%	50.00	406 / 406
ovary	100%	4636.13	180 / 180	100%	72.95	430 / 430
uterus	100%	5297.99	170 / 170	100%	63.90	459 / 459
brain	100%	7563.42	2640 / 2642	100%	86.38	705 / 705
breast	100%	7365.13	459 / 459	100%	95.03	1117 / 1118
thymus	100%	4577.31	653 / 653	100%	46.47	603 / 605
lung	100%	5339.64	576 / 578	100%	61.43	1155 / 1155
prostate	100%	4633.97	244 / 245	100%	52.00	501 / 502
kidney	100%	5350.08	89 / 89	99%	38.46	894 / 901
bladder	100%	4309.05	21 / 21	99%	51.69	499 / 504
adrenal gland	100%	5402.16	258 / 258	99%	50.29	227 / 230
stomach	100%	4016.65	359 / 359	99%	51.32	282 / 286
intestine	100%	5646.30	966 / 966	98%	51.36	518 / 527
skin	100%	5172.39	1805 / 1809	97%	38.32	457 / 472
pancreas	97%	2085.29	317 / 328	99%	40.25	177 / 178
lymph node	0%	0	0 / 0	100%	59.46	29 / 29
spleen	100%	7026.08	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	56.44	45 / 45
ureter	0%	0	0 / 0	100%	23.18	1 / 1
adipose	100%	6510.75	1203 / 1204	0%	0	0 / 0
muscle	100%	4663.51	802 / 803	0%	0	0 / 0
blood vessel	100%	6010.94	1332 / 1335	0%	0	0 / 0
heart	98%	4809.23	845 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	81%	18.50	65 / 80
peripheral blood	72%	5510.37	670 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0060261	Biological process	positive regulation of transcription initiation by RNA polymerase II
GO_0001111	Biological process	RNA polymerase II promoter clearance
GO_1905463	Biological process	negative regulation of DNA duplex unwinding
GO_0051053	Biological process	negative regulation of DNA metabolic process
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0005730	Cellular component	nucleolus
GO_0070062	Cellular component	extracellular exosome
GO_0005654	Cellular component	nucleoplasm
GO_0005667	Cellular component	transcription regulator complex
GO_0005634	Cellular component	nucleus
GO_0003723	Molecular function	RNA binding
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0003713	Molecular function	transcription coactivator activity
GO_0042802	Molecular function	identical protein binding
GO_0005515	Molecular function	protein binding
GO_0003697	Molecular function	single-stranded DNA binding

IV. Literature review

[source]

Gene name	SUB1
Protein name	SUB1 regulator of transcription Activated RNA polymerase II transcriptional coactivator p15 (SUB1 homolog) Activated RNA polymerase II transcriptional coactivator p15 (Positive cofactor 4) (PC4) (SUB1 homolog) (p14)
Synonyms	RPO2TC1 PC4 hCG_1781938
Description	FUNCTION: General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA). . FUNCTION: General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA). .
Accessions	ENST00000506237.5 P53999 ENST00000515355.5 ENST00000512913.5 ENST00000511615.5 ENST00000510442.1 D6RC37 D6R970 ENST00000265073.9 Q6IBA2 ENST00000502897.5

SUB1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review