SET report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006260Biological processDNA replication
GO_0006334Biological processnucleosome assembly
GO_0006337Biological processnucleosome disassembly
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0005811Cellular componentlipid droplet
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0042393Molecular functionhistone binding
GO_0003682Molecular functionchromatin binding
GO_0004864Molecular functionprotein phosphatase inhibitor activity
GO_0019888Molecular functionprotein phosphatase regulator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSET
Protein nameProtein SET (HLA-DR-associated protein II) (Inhibitor of granzyme A-activated DNase) (IGAAD) (PHAPII) (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I)
SET nuclear proto-oncogene
SET (cDNA FLJ51749, highly similar to Protein SET)
SynonymshCG_40357
DescriptionFUNCTION: Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher. .

AccessionsENST00000372692.8 [Q01105-1]
Q5VXV3
Q01105
A0A0C4DFV9
ENST00000691158.1
ENST00000686568.1
A0A8J8YYJ1
A0A8I5KTZ2
ENST00000372686.6
ENST00000322030.13 [Q01105-2]
ENST00000372688.9
ENST00000409104.7 [Q01105-4]
ENST00000686840.1 [Q01105-1]
A0A8I5KS71