FUS report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051260Biological processprotein homooligomerization
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0048255Biological processmRNA stabilization
GO_1990000Biological processamyloid fibril formation
GO_0008380Biological processRNA splicing
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0006355Biological processregulation of DNA-templated transcription
GO_1905168Biological processpositive regulation of double-strand break repair via homologous recombination
GO_0043484Biological processregulation of RNA splicing
GO_0005654Cellular componentnucleoplasm
GO_0043232Cellular componentintracellular non-membrane-bounded organelle
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0003682Molecular functionchromatin binding
GO_0042802Molecular functionidentical protein binding
GO_0003712Molecular functiontranscription coregulator activity
GO_0140693Molecular functionmolecular condensate scaffold activity
GO_0046872Molecular functionmetal ion binding
GO_0003723Molecular functionRNA binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0003730Molecular functionmRNA 3'-UTR binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFUS
Protein nameRNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)
FUS RNA binding protein
FUS protein (Fusion (Involved in t(1216) in malignant liposarcoma), isoform CRA_a) (Fusion, derived from t(12;16) malignant liposarcoma)
Fusion (Involved in t(1216) in malignant liposarcoma)
AltFUS
SynonymsTLS
hCG_21147
DescriptionFUNCTION: DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response . Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing . Binds also its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay . Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair . In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity). .

AccessionsENST00000380244.7 [P35637-2]
H3BNZ4
ENST00000254108.12 [P35637-1]
H3BPE7
Q6IBQ5
P35637
ENST00000566605.5
A0A823ADP9
Q8TBR3
ENST00000568685.1