CANX report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0048488Biological processsynaptic vesicle endocytosis
GO_0006457Biological processprotein folding
GO_0034975Biological processprotein folding in endoplasmic reticulum
GO_0019082Biological processviral protein processing
GO_0072583Biological processclathrin-dependent endocytosis
GO_0036503Biological processERAD pathway
GO_0009306Biological processprotein secretion
GO_0098793Cellular componentpresynapse
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0031966Cellular componentmitochondrial membrane
GO_0070062Cellular componentextracellular exosome
GO_0044322Cellular componentendoplasmic reticulum quality control compartment
GO_0033162Cellular componentmelanosome membrane
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0044233Cellular componentmitochondria-associated endoplasmic reticulum membrane contact site
GO_0005783Cellular componentendoplasmic reticulum
GO_0098553Cellular componentlumenal side of endoplasmic reticulum membrane
GO_0031965Cellular componentnuclear membrane
GO_0030246Molecular functioncarbohydrate binding
GO_0051082Molecular functionunfolded protein binding
GO_0003723Molecular functionRNA binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCANX
Protein nameCalnexin (IP90) (Major histocompatibility complex class I antigen-binding protein p88) (p90)
Calnexin
Synonyms
DescriptionFUNCTION: Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.

FUNCTION: Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse. .

FUNCTION: Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse. .

FUNCTION: Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse. .

FUNCTION: Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse. .

FUNCTION: Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse. .

FUNCTION: Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse. .

FUNCTION: Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse. .

FUNCTION: Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse. .

FUNCTION: Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse. .

FUNCTION: Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse. .

AccessionsENST00000681072.1 [P27824-1]
ENST00000681733.1 [P27824-1]
ENST00000680837.1
ENST00000681894.1
ENST00000509563
ENST00000681168.1 [P27824-1]
ENST00000513246.6 [P27824-1]
ENST00000680406.1
ENST00000680504.1
ENST00000679642.1
ENST00000679527.1
ENST00000680618.1 [P27824-1]
D6RAQ8
ENST00000680013.1 [P27824-1]
ENST00000639938.1 [P27824-1]
A0A7P0TAE9
A0A7P0TB65
D6RAU8
A0A7P0T9S1
ENST00000513246
ENST00000680614.1
P27824
ENST00000680984.1
D6RFL1
D6RFW4
ENST00000502296.6 [P27824-1]
ENST00000680042.1 [P27824-1]
A0A7P0T9S4
ENST00000681265.1
ENST00000679471.1
ENST00000638425.1 [P27824-1]
ENST00000504734.5 [P27824-1]
ENST00000681674.1 [P27824-1]
ENST00000680894.1
ENST00000514032.5
ENST00000247461.9 [P27824-1]
ENST00000680006.1 [P27824-3]
A0A7P0TAR9
A0A7P0T8N1
ENST00000506654.6 [P27824-3]
ENST00000680827.1 [P27824-3]
ENST00000681712.1 [P27824-1]
ENST00000681398.1
ENST00000680985.1
D6RD16
A0A7P0TA04
ENST00000681903.1 [P27824-1]
ENST00000681762.1
ENST00000681076.1
A0A7P0Z484
A0A7P0Z4D6
A0A7P0T8G1
D6RGY2
ENST00000680092.1 [P27824-1]
ENST00000681504.1
ENST00000502673.6
ENST00000506654
A0A7P0T9L0
ENST00000638706.2 [P27824-1]
A0A7P0T840
A0A7P0Z4H2
ENST00000452673.6 [P27824-1]
ENST00000681476.1 [P27824-1]
A0A7P0T937
ENST00000681431.1
A0A7P0TAN9
ENST00000680812.1
ENST00000681576.1
ENST00000502296
ENST00000509563.2 [P27824-1]