SLC25A5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051503Biological processadenine nucleotide transport
GO_0007059Biological processchromosome segregation
GO_1990830Biological processcellular response to leukemia inhibitory factor
GO_1901029Biological processnegative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO_1990845Biological processadaptive thermogenesis
GO_0030218Biological processerythrocyte differentiation
GO_0015853Biological processadenine transport
GO_1901526Biological processpositive regulation of mitophagy
GO_1990544Biological processmitochondrial ATP transmembrane transport
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0046902Biological processregulation of mitochondrial membrane permeability
GO_0030183Biological processB cell differentiation
GO_1902600Biological processproton transmembrane transport
GO_0140021Biological processmitochondrial ADP transmembrane transport
GO_0005886Cellular componentplasma membrane
GO_0042645Cellular componentmitochondrial nucleoid
GO_0016020Cellular componentmembrane
GO_0005739Cellular componentmitochondrion
GO_0005743Cellular componentmitochondrial inner membrane
GO_0071817Cellular componentMMXD complex
GO_0005757Cellular componentmitochondrial permeability transition pore complex
GO_0005634Cellular componentnucleus
GO_0015078Molecular functionproton transmembrane transporter activity
GO_0000295Molecular functionadenine nucleotide transmembrane transporter activity
GO_0015207Molecular functionadenine transmembrane transporter activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0005471Molecular functionATP:ADP antiporter activity
GO_0003723Molecular functionRNA binding
GO_0017077Molecular functionoxidative phosphorylation uncoupler activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSLC25A5
Protein nameADP/ATP translocase 2 (ADP,ATP carrier protein 2) (ADP,ATP carrier protein, fibroblast isoform) (Adenine nucleotide translocator 2) (ANT 2) (Solute carrier family 25 member 5) [Cleaved into: ADP/ATP translocase 2, N-terminally processed]
ADP/ATP translocase (ADP,ATP carrier protein)
SynonymsANT2
AAC2
DescriptionFUNCTION: ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (By similarity). Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis (By similarity). Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A5/ANT2 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity) (By similarity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it (By similarity). Probably mediates mitochondrial uncoupling in tissues that do not express UCP1 (By similarity). Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death . It is however unclear if SLC25A5/ANT2 constitutes a pore-forming component of mPTP or regulates it (By similarity). Acts as a regulator of mitophagy independently of ADP:ATP antiporter activity: promotes mitophagy via interaction with TIMM44, leading to inhibit the presequence translocase TIMM23, thereby promoting stabilization of PINK1 (By similarity). As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation . .

FUNCTION: Catalyzes the exchange of ADP and ATP across the membrane. .

AccessionsENST00000317881.9
Q6NVC0
P05141