PRDX1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	42 studies	58% ± 20%	Explore
B cell	41 studies	43% ± 16%	Explore
endothelial cell	40 studies	60% ± 21%	Explore
fibroblast	36 studies	62% ± 18%	Explore
T cell	30 studies	40% ± 17%	Explore
pericyte	30 studies	64% ± 16%	Explore
CD8-positive, alpha-beta T cell	30 studies	42% ± 21%	Explore
conventional dendritic cell	28 studies	47% ± 17%	Explore
CD4-positive, alpha-beta T cell	28 studies	41% ± 22%	Explore
regulatory T cell	27 studies	49% ± 20%	Explore
natural killer cell	25 studies	29% ± 15%	Explore
smooth muscle cell	25 studies	63% ± 14%	Explore
classical monocyte	25 studies	47% ± 16%	Explore
epithelial cell	25 studies	71% ± 22%	Explore
non-classical monocyte	24 studies	56% ± 16%	Explore
mast cell	23 studies	55% ± 20%	Explore
endothelial cell of lymphatic vessel	23 studies	70% ± 21%	Explore
plasma cell	22 studies	56% ± 21%	Explore
basal cell	22 studies	73% ± 18%	Explore
plasmacytoid dendritic cell	21 studies	37% ± 12%	Explore
dendritic cell	20 studies	44% ± 18%	Explore
monocyte	20 studies	49% ± 15%	Explore
memory B cell	19 studies	40% ± 15%	Explore
ciliated cell	18 studies	79% ± 18%	Explore
connective tissue cell	18 studies	61% ± 17%	Explore
naive B cell	17 studies	33% ± 12%	Explore
astrocyte	15 studies	38% ± 22%	Explore
capillary endothelial cell	15 studies	50% ± 18%	Explore
mature NK T cell	15 studies	33% ± 8%	Explore
gamma-delta T cell	15 studies	36% ± 15%	Explore
endothelial cell of artery	14 studies	55% ± 17%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	13 studies	33% ± 9%	Explore
myofibroblast cell	13 studies	62% ± 12%	Explore
myeloid cell	13 studies	60% ± 21%	Explore
plasmablast	12 studies	64% ± 19%	Explore
secretory cell	12 studies	76% ± 10%	Explore
oligodendrocyte	12 studies	31% ± 15%	Explore
vein endothelial cell	12 studies	61% ± 17%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	38% ± 18%	Explore
endothelial cell of vascular tree	11 studies	70% ± 14%	Explore
type I pneumocyte	10 studies	68% ± 26%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	46% ± 24%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	39% ± 14%	Explore
progenitor cell	10 studies	64% ± 16%	Explore
mesothelial cell	10 studies	65% ± 17%	Explore
mucosal invariant T cell	10 studies	34% ± 7%	Explore
type II pneumocyte	9 studies	58% ± 22%	Explore
leukocyte	9 studies	48% ± 15%	Explore
abnormal cell	9 studies	62% ± 15%	Explore
neuron	9 studies	53% ± 20%	Explore
goblet cell	9 studies	45% ± 14%	Explore
CD16-positive, CD56-dim natural killer cell, human	9 studies	22% ± 5%	Explore
club cell	8 studies	72% ± 22%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	55% ± 23%	Explore
enterocyte	8 studies	57% ± 22%	Explore
IgG plasma cell	8 studies	35% ± 15%	Explore
hematopoietic stem cell	8 studies	63% ± 18%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	36% ± 10%	Explore
ionocyte	7 studies	65% ± 11%	Explore
epithelial cell of proximal tubule	7 studies	76% ± 13%	Explore
IgA plasma cell	7 studies	35% ± 16%	Explore
retinal rod cell	7 studies	56% ± 25%	Explore
precursor B cell	7 studies	67% ± 16%	Explore
innate lymphoid cell	7 studies	35% ± 14%	Explore
erythrocyte	7 studies	52% ± 23%	Explore
alveolar macrophage	6 studies	75% ± 20%	Explore
respiratory goblet cell	6 studies	79% ± 16%	Explore
mononuclear phagocyte	6 studies	56% ± 19%	Explore
kidney loop of Henle epithelial cell	6 studies	63% ± 13%	Explore
renal alpha-intercalated cell	6 studies	79% ± 7%	Explore
erythroblast	6 studies	48% ± 17%	Explore
microglial cell	6 studies	52% ± 19%	Explore
retinal cone cell	6 studies	66% ± 29%	Explore
brush cell	6 studies	54% ± 24%	Explore
T follicular helper cell	6 studies	41% ± 13%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	51% ± 23%	Explore
oligodendrocyte precursor cell	6 studies	38% ± 20%	Explore
CD16-negative, CD56-bright natural killer cell, human	6 studies	29% ± 11%	Explore
CD4-positive helper T cell	5 studies	32% ± 12%	Explore
hematopoietic precursor cell	5 studies	53% ± 23%	Explore
neutrophil	5 studies	23% ± 9%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	76% ± 15%	Explore
transit amplifying cell	5 studies	44% ± 11%	Explore
retinal ganglion cell	5 studies	68% ± 22%	Explore
pro-B cell	5 studies	62% ± 12%	Explore
immature B cell	5 studies	49% ± 16%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	70% ± 18%	Explore
hepatocyte	5 studies	50% ± 30%	Explore
GABAergic neuron	5 studies	27% ± 11%	Explore
deuterosomal cell	4 studies	70% ± 10%	Explore
duct epithelial cell	4 studies	78% ± 5%	Explore
squamous epithelial cell	4 studies	54% ± 16%	Explore
pancreatic A cell	4 studies	42% ± 19%	Explore
type B pancreatic cell	4 studies	60% ± 15%	Explore
monocyte-derived dendritic cell	4 studies	58% ± 5%	Explore
glomerular endothelial cell	4 studies	58% ± 16%	Explore
podocyte	4 studies	72% ± 10%	Explore
enteroendocrine cell	4 studies	61% ± 11%	Explore
intestinal crypt stem cell	4 studies	53% ± 17%	Explore
glial cell	4 studies	59% ± 15%	Explore
amacrine cell	4 studies	38% ± 13%	Explore
retina horizontal cell	4 studies	54% ± 15%	Explore
retinal pigment epithelial cell	4 studies	59% ± 31%	Explore
adventitial cell	4 studies	71% ± 14%	Explore
mucus secreting cell	4 studies	48% ± 6%	Explore
Mueller cell	4 studies	51% ± 21%	Explore
acinar cell	4 studies	37% ± 22%	Explore
muscle cell	4 studies	39% ± 18%	Explore
germinal center B cell	4 studies	56% ± 23%	Explore
intermediate monocyte	4 studies	63% ± 20%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	78% ± 8%	Explore
granulocyte	4 studies	68% ± 17%	Explore
glutamatergic neuron	4 studies	37% ± 16%	Explore
melanocyte	4 studies	57% ± 24%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	36% ± 8%	Explore
precursor cell	3 studies	84% ± 7%	Explore
neural crest cell	3 studies	63% ± 3%	Explore
retinal bipolar neuron	3 studies	51% ± 18%	Explore
OFF-bipolar cell	3 studies	53% ± 23%	Explore
ON-bipolar cell	3 studies	48% ± 25%	Explore
renal principal cell	3 studies	80% ± 9%	Explore
extravillous trophoblast	3 studies	93% ± 5%	Explore
placental villous trophoblast	3 studies	98% ± 1%	Explore
lymphocyte	3 studies	59% ± 11%	Explore
neuroendocrine cell	3 studies	63% ± 11%	Explore
Schwann cell	3 studies	55% ± 27%	Explore
serous secreting cell	3 studies	47% ± 15%	Explore
tissue-resident macrophage	3 studies	49% ± 22%	Explore
intraepithelial lymphocyte	3 studies	36% ± 18%	Explore
rod bipolar cell	3 studies	35% ± 15%	Explore
exhausted T cell	3 studies	61% ± 17%	Explore
myoepithelial cell	3 studies	72% ± 9%	Explore
inflammatory macrophage	3 studies	45% ± 25%	Explore
luminal cell of prostate epithelium	3 studies	59% ± 9%	Explore
IgM plasma cell	3 studies	39% ± 10%	Explore
pancreatic ductal cell	3 studies	86% ± 2%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	66% ± 17%	Explore
group 3 innate lymphoid cell	3 studies	36% ± 19%	Explore
keratinocyte	3 studies	75% ± 6%	Explore
T-helper 17 cell	3 studies	59% ± 28%	Explore
interneuron	3 studies	26% ± 4%	Explore
T-helper 1 cell	3 studies	57% ± 26%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	36% ± 12%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	38% ± 14%	Explore
double negative thymocyte	3 studies	49% ± 23%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	66% ± 18%	Explore
progenitor cell of mammary luminal epithelium	3 studies	67% ± 12%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	18 studies	58% ± 16%	Explore
peripheral blood	18 studies	35% ± 13%	Explore
intestine	13 studies	45% ± 17%	Explore
brain	12 studies	34% ± 13%	Explore
eye	10 studies	47% ± 23%	Explore
kidney	9 studies	60% ± 12%	Explore
liver	8 studies	45% ± 18%	Explore
uterus	6 studies	58% ± 18%	Explore
lymph node	6 studies	50% ± 20%	Explore
pancreas	5 studies	48% ± 19%	Explore
bone marrow	5 studies	30% ± 10%	Explore
placenta	4 studies	74% ± 25%	Explore
esophagus	4 studies	56% ± 30%	Explore
prostate	4 studies	75% ± 14%	Explore
breast	4 studies	67% ± 4%	Explore
ovary	3 studies	47% ± 6%	Explore
heart	3 studies	29% ± 13%	Explore
adipose	3 studies	28% ± 7%	Explore
adrenal gland	3 studies	47% ± 6%	Explore
skin	3 studies	52% ± 23%	Explore
thymus	3 studies	66% ± 13%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	14930.10	1445 / 1445	100%	466.38	183 / 183
ovary	100%	6528.91	180 / 180	100%	352.91	430 / 430
breast	100%	8845.86	459 / 459	100%	560.85	1116 / 1118
uterus	100%	7260.32	170 / 170	100%	521.59	457 / 459
liver	100%	8524.71	225 / 226	100%	382.37	406 / 406
thymus	100%	17841.01	653 / 653	100%	485.18	602 / 605
lung	100%	9871.21	577 / 578	100%	607.37	1151 / 1155
stomach	100%	8576.42	359 / 359	99%	417.45	284 / 286
intestine	100%	8390.60	966 / 966	99%	409.85	523 / 527
bladder	100%	9677.00	21 / 21	98%	491.93	496 / 504
prostate	100%	6799.49	244 / 245	99%	276.59	495 / 502
kidney	100%	13009.89	89 / 89	98%	309.90	879 / 901
brain	100%	9013.39	2637 / 2642	94%	360.72	665 / 705
skin	100%	10184.04	1807 / 1809	94%	385.64	442 / 472
adrenal gland	100%	10794.79	258 / 258	85%	150.03	195 / 230
pancreas	60%	1617.37	197 / 328	97%	301.73	173 / 178
adipose	100%	8298.34	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	664.91	29 / 29
muscle	100%	10555.02	803 / 803	0%	0	0 / 0
spleen	100%	7665.01	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	541.05	45 / 45
ureter	0%	0	0 / 0	100%	253.55	1 / 1
blood vessel	100%	9451.84	1331 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	99%	376.08	79 / 80
heart	94%	9026.93	812 / 861	0%	0	0 / 0
peripheral blood	61%	5068.72	564 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0045454	Biological process	cell redox homeostasis
GO_1901222	Biological process	regulation of non-canonical NF-kappaB signal transduction
GO_0008283	Biological process	cell population proliferation
GO_0033554	Biological process	cellular response to stress
GO_0007249	Biological process	canonical NF-kappaB signal transduction
GO_0030101	Biological process	natural killer cell activation
GO_0042744	Biological process	hydrogen peroxide catabolic process
GO_0045321	Biological process	leukocyte activation
GO_0032872	Biological process	regulation of stress-activated MAPK cascade
GO_0042267	Biological process	natural killer cell mediated cytotoxicity
GO_0034101	Biological process	erythrocyte homeostasis
GO_0048144	Biological process	fibroblast proliferation
GO_0001501	Biological process	skeletal system development
GO_0019430	Biological process	removal of superoxide radicals
GO_0006979	Biological process	response to oxidative stress
GO_0005615	Cellular component	extracellular space
GO_0070062	Cellular component	extracellular exosome
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0042470	Cellular component	melanosome
GO_0005634	Cellular component	nucleus
GO_0004601	Molecular function	peroxidase activity
GO_0008379	Molecular function	thioredoxin peroxidase activity
GO_0045296	Molecular function	cadherin binding
GO_0042802	Molecular function	identical protein binding
GO_0003723	Molecular function	RNA binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PRDX1
Protein name	Peroxiredoxin-1 (EC 1.11.1.24) (Natural killer cell-enhancing factor A) (NKEF-A) (Proliferation-associated gene protein) (PAG) (Thioredoxin peroxidase 2) (Thioredoxin-dependent peroxide reductase 2) (Thioredoxin-dependent peroxiredoxin 1) thioredoxin-dependent peroxiredoxin (EC 1.11.1.24) Peroxiredoxin-1 (Thioredoxin-dependent peroxiredoxin 1)
Synonyms	PAGB TDPX2 PAGA
Description	FUNCTION: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) . Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity). .
Accessions	ENST00000447184.6 ENST00000676549.1 ENST00000262746.5 Q06830 ENST00000372079.1 ENST00000447184 ENST00000424390.2 A0A0A0MSI0 A0A0A0MRQ5 ENST00000319248.13 ENST00000424390

PRDX1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review