PNN | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	40 studies	41% ± 16%	Explore
endothelial cell	39 studies	33% ± 12%	Explore
fibroblast	38 studies	29% ± 11%	Explore
natural killer cell	36 studies	38% ± 15%	Explore
CD8-positive, alpha-beta T cell	32 studies	31% ± 12%	Explore
T cell	30 studies	31% ± 11%	Explore
pericyte	29 studies	31% ± 12%	Explore
CD4-positive, alpha-beta T cell	29 studies	32% ± 15%	Explore
smooth muscle cell	26 studies	31% ± 10%	Explore
conventional dendritic cell	23 studies	32% ± 17%	Explore
regulatory T cell	22 studies	31% ± 9%	Explore
macrophage	21 studies	26% ± 6%	Explore
mast cell	20 studies	28% ± 12%	Explore
memory B cell	20 studies	40% ± 10%	Explore
naive B cell	20 studies	38% ± 12%	Explore
basal cell	20 studies	31% ± 15%	Explore
mature NK T cell	19 studies	31% ± 11%	Explore
plasmacytoid dendritic cell	18 studies	46% ± 17%	Explore
epithelial cell	18 studies	38% ± 22%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	34% ± 15%	Explore
gamma-delta T cell	17 studies	37% ± 15%	Explore
endothelial cell of lymphatic vessel	16 studies	32% ± 9%	Explore
CD16-negative, CD56-bright natural killer cell, human	16 studies	40% ± 18%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	40% ± 16%	Explore
classical monocyte	15 studies	28% ± 16%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	37% ± 16%	Explore
myofibroblast cell	14 studies	34% ± 13%	Explore
monocyte	13 studies	27% ± 8%	Explore
plasma cell	13 studies	28% ± 12%	Explore
ciliated cell	13 studies	30% ± 15%	Explore
capillary endothelial cell	13 studies	25% ± 8%	Explore
connective tissue cell	13 studies	35% ± 14%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	34% ± 9%	Explore
non-classical monocyte	12 studies	31% ± 19%	Explore
vein endothelial cell	12 studies	28% ± 10%	Explore
mucosal invariant T cell	12 studies	32% ± 8%	Explore
endothelial cell of vascular tree	12 studies	30% ± 8%	Explore
astrocyte	12 studies	31% ± 11%	Explore
dendritic cell	11 studies	38% ± 21%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	31% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell	11 studies	37% ± 20%	Explore
myeloid cell	11 studies	27% ± 11%	Explore
abnormal cell	10 studies	33% ± 15%	Explore
type I pneumocyte	9 studies	32% ± 8%	Explore
oligodendrocyte precursor cell	9 studies	29% ± 9%	Explore
type II pneumocyte	8 studies	28% ± 10%	Explore
plasmablast	8 studies	49% ± 24%	Explore
progenitor cell	8 studies	38% ± 16%	Explore
endothelial cell of artery	8 studies	29% ± 6%	Explore
goblet cell	8 studies	26% ± 12%	Explore
mesothelial cell	8 studies	41% ± 14%	Explore
microglial cell	8 studies	29% ± 6%	Explore
adipocyte	8 studies	35% ± 16%	Explore
oligodendrocyte	8 studies	28% ± 10%	Explore
secretory cell	7 studies	40% ± 12%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	29% ± 5%	Explore
leukocyte	7 studies	35% ± 11%	Explore
neuron	7 studies	40% ± 16%	Explore
hematopoietic stem cell	7 studies	64% ± 12%	Explore
precursor B cell	7 studies	48% ± 10%	Explore
club cell	7 studies	26% ± 8%	Explore
immature B cell	7 studies	50% ± 11%	Explore
T follicular helper cell	7 studies	31% ± 7%	Explore
amacrine cell	6 studies	37% ± 12%	Explore
retinal rod cell	6 studies	27% ± 7%	Explore
lymphocyte	6 studies	37% ± 14%	Explore
innate lymphoid cell	6 studies	35% ± 10%	Explore
hematopoietic precursor cell	5 studies	60% ± 20%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	27% ± 7%	Explore
enteroendocrine cell	5 studies	32% ± 12%	Explore
transit amplifying cell	5 studies	28% ± 14%	Explore
interneuron	5 studies	37% ± 20%	Explore
pro-B cell	5 studies	55% ± 9%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	45% ± 16%	Explore
GABAergic neuron	5 studies	36% ± 8%	Explore
glutamatergic neuron	5 studies	42% ± 15%	Explore
deuterosomal cell	4 studies	24% ± 10%	Explore
ionocyte	4 studies	27% ± 10%	Explore
pancreatic A cell	4 studies	46% ± 14%	Explore
mononuclear phagocyte	4 studies	30% ± 18%	Explore
exhausted T cell	4 studies	39% ± 21%	Explore
renal alpha-intercalated cell	4 studies	32% ± 12%	Explore
enterocyte	4 studies	20% ± 3%	Explore
retinal bipolar neuron	4 studies	42% ± 11%	Explore
retinal ganglion cell	4 studies	31% ± 11%	Explore
kidney loop of Henle epithelial cell	4 studies	21% ± 3%	Explore
erythroblast	4 studies	44% ± 24%	Explore
brush cell	4 studies	35% ± 10%	Explore
retina horizontal cell	4 studies	36% ± 14%	Explore
retinal cone cell	4 studies	33% ± 13%	Explore
retinal pigment epithelial cell	4 studies	36% ± 13%	Explore
Mueller cell	4 studies	29% ± 9%	Explore
respiratory goblet cell	4 studies	29% ± 8%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	30% ± 10%	Explore
hepatocyte	4 studies	47% ± 18%	Explore
granulocyte	4 studies	30% ± 9%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	64% ± 23%	Explore
erythrocyte	4 studies	34% ± 15%	Explore
keratinocyte	4 studies	19% ± 4%	Explore
T-helper 17 cell	4 studies	31% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	26% ± 3%	Explore
double negative thymocyte	4 studies	52% ± 17%	Explore
pancreatic D cell	3 studies	45% ± 21%	Explore
type B pancreatic cell	3 studies	50% ± 16%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	39% ± 14%	Explore
epithelial cell of proximal tubule	3 studies	22% ± 8%	Explore
intestinal crypt stem cell	3 studies	26% ± 2%	Explore
neural crest cell	3 studies	52% ± 5%	Explore
glial cell	3 studies	36% ± 22%	Explore
placental villous trophoblast	3 studies	25% ± 8%	Explore
cardiac muscle cell	3 studies	21% ± 1%	Explore
rod bipolar cell	3 studies	35% ± 14%	Explore
acinar cell	3 studies	33% ± 12%	Explore
germinal center B cell	3 studies	40% ± 5%	Explore
CD4-positive helper T cell	3 studies	37% ± 8%	Explore
myoepithelial cell	3 studies	34% ± 10%	Explore
muscle cell	3 studies	35% ± 13%	Explore
pancreatic ductal cell	3 studies	48% ± 14%	Explore
mucus secreting cell	3 studies	17% ± 1%	Explore
group 3 innate lymphoid cell	3 studies	50% ± 14%	Explore
T-helper 1 cell	3 studies	31% ± 6%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	36% ± 6%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	34% ± 9%	Explore
progenitor cell of mammary luminal epithelium	3 studies	26% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	16 studies	38% ± 17%	Explore
lung	15 studies	31% ± 10%	Explore
intestine	10 studies	30% ± 17%	Explore
brain	10 studies	33% ± 12%	Explore
kidney	8 studies	23% ± 8%	Explore
eye	8 studies	32% ± 9%	Explore
liver	5 studies	41% ± 13%	Explore
pancreas	4 studies	41% ± 18%	Explore
bone marrow	4 studies	34% ± 11%	Explore
heart	4 studies	21% ± 5%	Explore
uterus	4 studies	42% ± 16%	Explore
breast	4 studies	27% ± 9%	Explore
lymph node	4 studies	39% ± 13%	Explore
adipose	4 studies	37% ± 16%	Explore
placenta	3 studies	21% ± 3%	Explore
prostate	3 studies	27% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	14775.71	245 / 245	100%	74.00	502 / 502
uterus	100%	15229.55	170 / 170	100%	96.36	459 / 459
esophagus	100%	11207.45	1444 / 1445	100%	79.86	183 / 183
intestine	100%	13741.98	966 / 966	100%	73.80	526 / 527
bladder	100%	11739.14	21 / 21	100%	76.33	503 / 504
thymus	100%	15870.26	653 / 653	100%	78.22	602 / 605
breast	100%	10797.00	459 / 459	99%	81.44	1112 / 1118
pancreas	100%	7343.74	328 / 328	99%	73.27	177 / 178
lung	100%	10483.92	577 / 578	100%	79.70	1150 / 1155
ovary	100%	13579.18	180 / 180	99%	58.33	427 / 430
stomach	100%	9188.47	359 / 359	99%	63.77	284 / 286
brain	99%	6985.26	2623 / 2642	100%	81.41	702 / 705
kidney	100%	10623.64	89 / 89	97%	53.57	877 / 901
skin	100%	9895.97	1809 / 1809	97%	64.43	457 / 472
adrenal gland	100%	9428.56	258 / 258	97%	50.55	222 / 230
liver	100%	10476.04	226 / 226	95%	39.58	387 / 406
adipose	100%	9415.44	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	86.87	29 / 29
spleen	100%	17403.09	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	75.52	45 / 45
ureter	0%	0	0 / 0	100%	36.56	1 / 1
blood vessel	100%	10077.91	1334 / 1335	0%	0	0 / 0
muscle	100%	5768.08	801 / 803	0%	0	0 / 0
heart	99%	5380.30	852 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	86%	36.69	69 / 80
peripheral blood	81%	6105.34	756 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0000398	Biological process	mRNA splicing, via spliceosome
GO_0007155	Biological process	cell adhesion
GO_0005911	Cellular component	cell-cell junction
GO_0016607	Cellular component	nuclear speck
GO_0030057	Cellular component	desmosome
GO_0035145	Cellular component	exon-exon junction complex
GO_0071013	Cellular component	catalytic step 2 spliceosome
GO_0005654	Cellular component	nucleoplasm
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0005882	Cellular component	intermediate filament
GO_0003677	Molecular function	DNA binding
GO_0005515	Molecular function	protein binding
GO_0005198	Molecular function	structural molecule activity
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	PNN
Protein name	Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Desmosome-associated protein) (Domain-rich serine protein) (DRS protein) (DRSP) (Melanoma metastasis clone A protein) (Nuclear protein SDK3) (SR-like protein) Pinin, desmosome associated protein
Synonyms	MEMA DRS
Description	FUNCTION: Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Component of the PSAP complex which binds RNA in a sequence-independent manner and is proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma. .
Accessions	Q9H307 G3V579 ENST00000553331.5 ENST00000556530.1 ENST00000216832.9 G3V5F0

PNN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review