NUCKS1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	45 studies	46% ± 18%	Explore
fibroblast	43 studies	55% ± 19%	Explore
pericyte	37 studies	54% ± 19%	Explore
B cell	36 studies	36% ± 13%	Explore
macrophage	36 studies	35% ± 14%	Explore
natural killer cell	35 studies	38% ± 15%	Explore
T cell	34 studies	37% ± 17%	Explore
CD8-positive, alpha-beta T cell	34 studies	39% ± 17%	Explore
smooth muscle cell	31 studies	53% ± 21%	Explore
CD4-positive, alpha-beta T cell	30 studies	37% ± 17%	Explore
conventional dendritic cell	27 studies	40% ± 19%	Explore
regulatory T cell	24 studies	35% ± 9%	Explore
endothelial cell of lymphatic vessel	22 studies	50% ± 18%	Explore
basal cell	22 studies	49% ± 18%	Explore
epithelial cell	22 studies	49% ± 23%	Explore
mast cell	21 studies	38% ± 17%	Explore
memory B cell	20 studies	31% ± 9%	Explore
plasmacytoid dendritic cell	20 studies	37% ± 13%	Explore
connective tissue cell	20 studies	54% ± 23%	Explore
astrocyte	20 studies	42% ± 17%	Explore
ciliated cell	19 studies	51% ± 21%	Explore
naive B cell	18 studies	33% ± 9%	Explore
mature NK T cell	18 studies	33% ± 9%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	35% ± 11%	Explore
gamma-delta T cell	17 studies	39% ± 14%	Explore
dendritic cell	16 studies	41% ± 22%	Explore
classical monocyte	16 studies	24% ± 10%	Explore
non-classical monocyte	16 studies	25% ± 12%	Explore
oligodendrocyte	16 studies	42% ± 15%	Explore
monocyte	15 studies	34% ± 14%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	37% ± 10%	Explore
oligodendrocyte precursor cell	15 studies	36% ± 16%	Explore
myofibroblast cell	15 studies	61% ± 20%	Explore
microglial cell	15 studies	31% ± 12%	Explore
myeloid cell	15 studies	40% ± 22%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	35% ± 11%	Explore
capillary endothelial cell	14 studies	38% ± 11%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	41% ± 11%	Explore
mucosal invariant T cell	13 studies	32% ± 8%	Explore
endothelial cell of vascular tree	13 studies	41% ± 17%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	40% ± 11%	Explore
secretory cell	12 studies	47% ± 23%	Explore
endothelial cell of artery	12 studies	45% ± 11%	Explore
vein endothelial cell	12 studies	44% ± 13%	Explore
type II pneumocyte	11 studies	41% ± 20%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	37% ± 10%	Explore
club cell	11 studies	38% ± 20%	Explore
glutamatergic neuron	11 studies	55% ± 17%	Explore
effector memory CD8-positive, alpha-beta T cell	11 studies	36% ± 14%	Explore
progenitor cell	11 studies	51% ± 23%	Explore
type I pneumocyte	10 studies	39% ± 20%	Explore
GABAergic neuron	10 studies	46% ± 18%	Explore
abnormal cell	10 studies	54% ± 21%	Explore
neuron	10 studies	55% ± 16%	Explore
mesothelial cell	10 studies	56% ± 25%	Explore
plasmablast	9 studies	44% ± 20%	Explore
innate lymphoid cell	9 studies	33% ± 12%	Explore
goblet cell	9 studies	36% ± 15%	Explore
retinal rod cell	9 studies	34% ± 14%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	50% ± 14%	Explore
leukocyte	8 studies	43% ± 15%	Explore
amacrine cell	8 studies	51% ± 26%	Explore
plasma cell	8 studies	33% ± 12%	Explore
alveolar macrophage	7 studies	28% ± 5%	Explore
respiratory goblet cell	7 studies	33% ± 19%	Explore
epithelial cell of proximal tubule	7 studies	38% ± 19%	Explore
kidney loop of Henle epithelial cell	7 studies	43% ± 17%	Explore
hematopoietic stem cell	7 studies	53% ± 18%	Explore
precursor B cell	7 studies	48% ± 21%	Explore
T follicular helper cell	7 studies	32% ± 7%	Explore
hematopoietic precursor cell	6 studies	61% ± 26%	Explore
ionocyte	6 studies	49% ± 6%	Explore
mononuclear phagocyte	6 studies	36% ± 17%	Explore
renal alpha-intercalated cell	6 studies	55% ± 14%	Explore
transit amplifying cell	6 studies	57% ± 21%	Explore
glial cell	6 studies	44% ± 21%	Explore
interneuron	6 studies	50% ± 24%	Explore
retinal ganglion cell	6 studies	62% ± 32%	Explore
retinal cone cell	6 studies	45% ± 24%	Explore
lymphocyte	6 studies	46% ± 22%	Explore
retina horizontal cell	6 studies	52% ± 25%	Explore
adipocyte	6 studies	26% ± 5%	Explore
cardiac muscle cell	6 studies	26% ± 8%	Explore
Mueller cell	6 studies	48% ± 22%	Explore
erythrocyte	6 studies	38% ± 24%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	40% ± 13%	Explore
hepatocyte	6 studies	54% ± 22%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	41% ± 4%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	67% ± 14%	Explore
enteroendocrine cell	5 studies	49% ± 17%	Explore
intestinal crypt stem cell	5 studies	37% ± 12%	Explore
retinal bipolar neuron	5 studies	51% ± 26%	Explore
OFF-bipolar cell	5 studies	50% ± 25%	Explore
ON-bipolar cell	5 studies	52% ± 24%	Explore
erythroblast	5 studies	51% ± 32%	Explore
pro-B cell	5 studies	56% ± 15%	Explore
brush cell	5 studies	36% ± 19%	Explore
immature B cell	5 studies	43% ± 11%	Explore
adventitial cell	5 studies	45% ± 15%	Explore
deuterosomal cell	4 studies	29% ± 6%	Explore
duct epithelial cell	4 studies	33% ± 10%	Explore
precursor cell	4 studies	51% ± 22%	Explore
platelet	4 studies	19% ± 2%	Explore
pancreatic A cell	4 studies	73% ± 16%	Explore
type B pancreatic cell	4 studies	64% ± 22%	Explore
exhausted T cell	4 studies	50% ± 9%	Explore
glomerular endothelial cell	4 studies	46% ± 11%	Explore
GABAergic amacrine cell	4 studies	43% ± 14%	Explore
glycinergic amacrine cell	4 studies	44% ± 14%	Explore
retinal pigment epithelial cell	4 studies	53% ± 24%	Explore
mucus secreting cell	4 studies	19% ± 3%	Explore
muscle cell	4 studies	47% ± 18%	Explore
germinal center B cell	4 studies	38% ± 15%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	54% ± 6%	Explore
myoepithelial cell	4 studies	48% ± 17%	Explore
granulocyte	4 studies	34% ± 11%	Explore
luminal cell of prostate epithelium	4 studies	32% ± 10%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	69% ± 29%	Explore
T-helper 17 cell	4 studies	41% ± 22%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	28% ± 5%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	36% ± 10%	Explore
double negative thymocyte	4 studies	49% ± 20%	Explore
hillock cell	3 studies	35% ± 6%	Explore
pancreatic D cell	3 studies	74% ± 17%	Explore
monocyte-derived dendritic cell	3 studies	43% ± 13%	Explore
podocyte	3 studies	70% ± 9%	Explore
differentiation-committed oligodendrocyte precursor	3 studies	43% ± 14%	Explore
enterocyte	3 studies	28% ± 13%	Explore
neural crest cell	3 studies	81% ± 6%	Explore
GABAergic interneuron	3 studies	39% ± 11%	Explore
renal principal cell	3 studies	52% ± 2%	Explore
extravillous trophoblast	3 studies	54% ± 5%	Explore
placental villous trophoblast	3 studies	56% ± 13%	Explore
megakaryocyte	3 studies	34% ± 15%	Explore
neuroendocrine cell	3 studies	52% ± 14%	Explore
Schwann cell	3 studies	64% ± 17%	Explore
tissue-resident macrophage	3 studies	29% ± 6%	Explore
rod bipolar cell	3 studies	68% ± 16%	Explore
intermediate monocyte	3 studies	39% ± 21%	Explore
CD4-positive helper T cell	3 studies	32% ± 7%	Explore
pancreatic ductal cell	3 studies	60% ± 22%	Explore
ependymal cell	3 studies	49% ± 17%	Explore
chondrocyte	3 studies	36% ± 15%	Explore
group 3 innate lymphoid cell	3 studies	49% ± 16%	Explore
melanocyte	3 studies	43% ± 5%	Explore
keratinocyte	3 studies	41% ± 8%	Explore
granule cell	3 studies	43% ± 13%	Explore
T-helper 1 cell	3 studies	39% ± 10%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	33% ± 6%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	47% ± 7%	Explore
progenitor cell of mammary luminal epithelium	3 studies	32% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	20 studies	43% ± 17%	Explore
lung	19 studies	42% ± 18%	Explore
peripheral blood	17 studies	34% ± 12%	Explore
intestine	12 studies	37% ± 20%	Explore
eye	12 studies	44% ± 17%	Explore
kidney	9 studies	43% ± 14%	Explore
liver	7 studies	47% ± 19%	Explore
heart	6 studies	25% ± 10%	Explore
lymph node	6 studies	44% ± 19%	Explore
bone marrow	5 studies	38% ± 20%	Explore
uterus	5 studies	58% ± 22%	Explore
pancreas	4 studies	61% ± 23%	Explore
breast	4 studies	42% ± 6%	Explore
prostate	4 studies	29% ± 9%	Explore
placenta	3 studies	55% ± 5%	Explore
ovary	3 studies	46% ± 21%	Explore
skin	3 studies	33% ± 12%	Explore
thymus	3 studies	58% ± 29%	Explore
adipose	3 studies	28% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	20326.66	2642 / 2642	100%	267.62	705 / 705
breast	100%	15281.80	459 / 459	100%	308.55	1118 / 1118
esophagus	100%	13816.48	1445 / 1445	100%	214.97	183 / 183
liver	100%	8503.57	226 / 226	100%	150.35	406 / 406
ovary	100%	21288.39	180 / 180	100%	179.24	430 / 430
prostate	100%	15245.90	245 / 245	100%	190.87	502 / 502
thymus	100%	17423.28	653 / 653	100%	233.57	605 / 605
uterus	100%	19458.71	170 / 170	100%	237.55	459 / 459
lung	100%	13518.87	577 / 578	100%	193.80	1155 / 1155
bladder	100%	15684.00	21 / 21	99%	159.86	501 / 504
intestine	100%	13944.21	965 / 966	99%	130.62	520 / 527
kidney	100%	11594.28	89 / 89	98%	148.47	884 / 901
stomach	100%	9521.76	359 / 359	98%	128.29	279 / 286
adrenal gland	100%	11634.19	258 / 258	97%	153.44	224 / 230
skin	100%	15339.57	1809 / 1809	97%	202.82	459 / 472
pancreas	96%	5098.75	315 / 328	99%	141.26	176 / 178
adipose	100%	14784.88	1204 / 1204	0%	0	0 / 0
blood vessel	100%	16386.34	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	137.44	29 / 29
spleen	100%	9699.14	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	215.05	45 / 45
ureter	0%	0	0 / 0	100%	177.26	1 / 1
muscle	100%	12710.22	802 / 803	0%	0	0 / 0
heart	99%	13819.31	851 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	91%	93.77	73 / 80
peripheral blood	41%	4761.53	381 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006325	Biological process	chromatin organization
GO_0036297	Biological process	interstrand cross-link repair
GO_0044829	Biological process	positive regulation by host of viral genome replication
GO_0060382	Biological process	regulation of DNA strand elongation
GO_0001678	Biological process	intracellular glucose homeostasis
GO_0000724	Biological process	double-strand break repair via homologous recombination
GO_0031297	Biological process	replication fork processing
GO_0071481	Biological process	cellular response to X-ray
GO_1990969	Biological process	modulation by host of viral RNA-binding transcription factor activity
GO_0043923	Biological process	positive regulation by host of viral transcription
GO_0035822	Biological process	gene conversion
GO_0046628	Biological process	positive regulation of insulin receptor signaling pathway
GO_1990968	Biological process	modulation by host of RNA binding by virus
GO_0046626	Biological process	regulation of insulin receptor signaling pathway
GO_0006275	Biological process	regulation of DNA replication
GO_0044827	Biological process	modulation by host of viral genome replication
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0005730	Cellular component	nucleolus
GO_0005654	Cellular component	nucleoplasm
GO_0005737	Cellular component	cytoplasm
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_0140297	Molecular function	DNA-binding transcription factor binding
GO_0003682	Molecular function	chromatin binding
GO_0003697	Molecular function	single-stranded DNA binding
GO_0003690	Molecular function	double-stranded DNA binding
GO_0003723	Molecular function	RNA binding
GO_0003713	Molecular function	transcription coactivator activity

Gene name	NUCKS1
Protein name	Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (P1)
Synonyms	NUCKS JC7
Description	FUNCTION: Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR) . Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures, but with less affinity than RAD51AP1 . .
Accessions	ENST00000367142.5 [Q9H1E3-1] Q9H1E3

NUCKS1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review