MACF1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	53 studies	53% ± 23%	Explore
natural killer cell	38 studies	37% ± 15%	Explore
fibroblast	38 studies	47% ± 23%	Explore
pericyte	32 studies	38% ± 20%	Explore
smooth muscle cell	32 studies	41% ± 21%	Explore
macrophage	31 studies	38% ± 20%	Explore
CD8-positive, alpha-beta T cell	29 studies	31% ± 14%	Explore
T cell	28 studies	33% ± 15%	Explore
CD4-positive, alpha-beta T cell	27 studies	27% ± 11%	Explore
B cell	25 studies	26% ± 10%	Explore
endothelial cell of lymphatic vessel	22 studies	51% ± 21%	Explore
regulatory T cell	22 studies	26% ± 9%	Explore
astrocyte	20 studies	78% ± 20%	Explore
ciliated cell	19 studies	42% ± 20%	Explore
gamma-delta T cell	18 studies	36% ± 12%	Explore
mature NK T cell	18 studies	34% ± 12%	Explore
non-classical monocyte	18 studies	27% ± 11%	Explore
mast cell	16 studies	36% ± 16%	Explore
CD16-negative, CD56-bright natural killer cell, human	16 studies	39% ± 11%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	42% ± 12%	Explore
classical monocyte	15 studies	24% ± 9%	Explore
oligodendrocyte precursor cell	15 studies	68% ± 20%	Explore
capillary endothelial cell	15 studies	44% ± 17%	Explore
vein endothelial cell	15 studies	46% ± 22%	Explore
basal cell	14 studies	39% ± 20%	Explore
oligodendrocyte	14 studies	65% ± 16%	Explore
endothelial cell of artery	14 studies	43% ± 16%	Explore
microglial cell	14 studies	62% ± 16%	Explore
mucosal invariant T cell	14 studies	32% ± 8%	Explore
dendritic cell	13 studies	37% ± 14%	Explore
effector memory CD8-positive, alpha-beta T cell	13 studies	36% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	36% ± 14%	Explore
naive B cell	13 studies	25% ± 7%	Explore
myofibroblast cell	13 studies	38% ± 18%	Explore
monocyte	12 studies	35% ± 17%	Explore
type I pneumocyte	12 studies	48% ± 22%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	31% ± 10%	Explore
epithelial cell	12 studies	43% ± 26%	Explore
endothelial cell of vascular tree	12 studies	39% ± 17%	Explore
type II pneumocyte	11 studies	52% ± 28%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	11 studies	27% ± 10%	Explore
glutamatergic neuron	11 studies	74% ± 17%	Explore
adipocyte	11 studies	63% ± 18%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	27% ± 8%	Explore
connective tissue cell	10 studies	31% ± 13%	Explore
GABAergic neuron	10 studies	73% ± 17%	Explore
memory B cell	10 studies	21% ± 6%	Explore
myeloid cell	10 studies	45% ± 17%	Explore
neuron	9 studies	53% ± 24%	Explore
amacrine cell	8 studies	52% ± 16%	Explore
retinal cone cell	8 studies	73% ± 17%	Explore
retinal rod cell	8 studies	54% ± 21%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	31% ± 10%	Explore
leukocyte	7 studies	44% ± 17%	Explore
conventional dendritic cell	7 studies	27% ± 16%	Explore
retinal ganglion cell	7 studies	75% ± 16%	Explore
hematopoietic stem cell	7 studies	35% ± 16%	Explore
club cell	7 studies	47% ± 18%	Explore
mesothelial cell	7 studies	46% ± 17%	Explore
innate lymphoid cell	7 studies	35% ± 10%	Explore
hematopoietic precursor cell	6 studies	37% ± 15%	Explore
respiratory goblet cell	6 studies	47% ± 18%	Explore
progenitor cell	6 studies	37% ± 21%	Explore
interneuron	6 studies	79% ± 14%	Explore
lymphocyte	6 studies	50% ± 17%	Explore
retina horizontal cell	6 studies	54% ± 20%	Explore
Mueller cell	6 studies	57% ± 23%	Explore
T follicular helper cell	6 studies	22% ± 5%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	31% ± 7%	Explore
goblet cell	6 studies	33% ± 27%	Explore
exhausted T cell	5 studies	36% ± 14%	Explore
secretory cell	5 studies	40% ± 15%	Explore
hepatocyte	5 studies	61% ± 27%	Explore
abnormal cell	5 studies	42% ± 14%	Explore
retinal bipolar neuron	5 studies	64% ± 16%	Explore
cardiac muscle cell	5 studies	69% ± 14%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	34% ± 11%	Explore
alveolar macrophage	4 studies	45% ± 19%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	21% ± 6%	Explore
ionocyte	4 studies	37% ± 14%	Explore
squamous epithelial cell	4 studies	42% ± 21%	Explore
plasmablast	4 studies	36% ± 20%	Explore
plasmacytoid dendritic cell	4 studies	21% ± 6%	Explore
platelet	4 studies	25% ± 8%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	31% ± 5%	Explore
cholangiocyte	4 studies	65% ± 24%	Explore
endothelial cell of sinusoid	4 studies	51% ± 22%	Explore
differentiation-committed oligodendrocyte precursor	4 studies	61% ± 22%	Explore
glial cell	4 studies	41% ± 17%	Explore
granule cell	4 studies	61% ± 7%	Explore
pro-B cell	4 studies	31% ± 10%	Explore
brush cell	4 studies	32% ± 8%	Explore
retinal pigment epithelial cell	4 studies	63% ± 21%	Explore
mononuclear phagocyte	4 studies	38% ± 15%	Explore
OFF-bipolar cell	4 studies	70% ± 10%	Explore
ON-bipolar cell	4 studies	71% ± 12%	Explore
luminal cell of prostate epithelium	4 studies	27% ± 11%	Explore
muscle cell	4 studies	46% ± 16%	Explore
enteroendocrine cell	4 studies	26% ± 6%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	31% ± 14%	Explore
double negative thymocyte	4 studies	35% ± 7%	Explore
kidney loop of Henle epithelial cell	4 studies	35% ± 17%	Explore
hepatic stellate cell	3 studies	74% ± 11%	Explore
glomerular endothelial cell	3 studies	39% ± 6%	Explore
renal beta-intercalated cell	3 studies	62% ± 31%	Explore
interstitial cell of Cajal	3 studies	31% ± 15%	Explore
GABAergic interneuron	3 studies	79% ± 3%	Explore
megakaryocyte	3 studies	36% ± 14%	Explore
plasma cell	3 studies	37% ± 5%	Explore
endocardial cell	3 studies	48% ± 12%	Explore
tissue-resident macrophage	3 studies	38% ± 17%	Explore
GABAergic amacrine cell	3 studies	71% ± 10%	Explore
glycinergic amacrine cell	3 studies	56% ± 12%	Explore
rod bipolar cell	3 studies	75% ± 10%	Explore
erythroblast	3 studies	23% ± 8%	Explore
intermediate monocyte	3 studies	36% ± 21%	Explore
CD4-positive helper T cell	3 studies	29% ± 6%	Explore
neural progenitor cell	3 studies	61% ± 31%	Explore
ependymal cell	3 studies	84% ± 2%	Explore
adventitial cell	3 studies	50% ± 12%	Explore
group 3 innate lymphoid cell	3 studies	48% ± 13%	Explore
keratinocyte	3 studies	40% ± 17%	Explore
T-helper 17 cell	3 studies	23% ± 4%	Explore
T-helper 1 cell	3 studies	24% ± 2%	Explore
immature B cell	3 studies	19% ± 1%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	25% ± 3%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	43% ± 19%	Explore
podocyte	3 studies	71% ± 22%	Explore
renal alpha-intercalated cell	3 studies	65% ± 24%	Explore
renal principal cell	3 studies	49% ± 12%	Explore
mural cell	3 studies	68% ± 13%	Explore
mucus secreting cell	3 studies	59% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	17 studies	27% ± 12%	Explore
brain	17 studies	68% ± 16%	Explore
lung	16 studies	40% ± 17%	Explore
eye	9 studies	58% ± 19%	Explore
liver	7 studies	33% ± 18%	Explore
kidney	7 studies	39% ± 18%	Explore
intestine	5 studies	22% ± 6%	Explore
heart	5 studies	54% ± 16%	Explore
bone marrow	4 studies	35% ± 15%	Explore
uterus	4 studies	34% ± 13%	Explore
breast	4 studies	30% ± 13%	Explore
adipose	4 studies	51% ± 17%	Explore
lymph node	3 studies	20% ± 3%	Explore
skin	3 studies	30% ± 16%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	99%	27885.20	1435 / 1445	100%	31.71	183 / 183
brain	100%	25912.22	2641 / 2642	99%	33.36	700 / 705
thymus	100%	25654.03	653 / 653	99%	31.90	597 / 605
breast	100%	19576.41	459 / 459	98%	29.35	1098 / 1118
prostate	100%	20710.24	244 / 245	97%	19.08	488 / 502
lung	100%	66921.80	578 / 578	96%	21.70	1105 / 1155
skin	100%	33996.61	1808 / 1809	96%	20.28	451 / 472
kidney	100%	17817.18	89 / 89	95%	19.57	857 / 901
uterus	100%	40119.25	170 / 170	94%	16.49	430 / 459
stomach	98%	18429.73	352 / 359	92%	16.73	264 / 286
ovary	100%	29409.22	180 / 180	89%	14.77	382 / 430
intestine	100%	31864.34	963 / 966	89%	12.68	468 / 527
pancreas	88%	7514.31	290 / 328	98%	22.11	175 / 178
bladder	100%	24474.86	21 / 21	86%	13.24	435 / 504
adrenal gland	100%	17384.74	258 / 258	84%	9.86	193 / 230
liver	94%	8141.80	212 / 226	63%	6.86	254 / 406
adipose	100%	22814.00	1204 / 1204	0%	0	0 / 0
blood vessel	100%	41919.64	1335 / 1335	0%	0	0 / 0
spleen	100%	22630.07	241 / 241	0%	0	0 / 0
muscle	97%	10682.49	782 / 803	0%	0	0 / 0
heart	97%	20232.36	836 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	91%	16.55	41 / 45
peripheral blood	63%	7985.22	586 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	63%	6.87	50 / 80
lymph node	0%	0	0 / 0	62%	10.31	18 / 29
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0032886	Biological process	regulation of microtubule-based process
GO_0045773	Biological process	positive regulation of axon extension
GO_0042060	Biological process	wound healing
GO_0030177	Biological process	positive regulation of Wnt signaling pathway
GO_0030334	Biological process	regulation of cell migration
GO_0045104	Biological process	intermediate filament cytoskeleton organization
GO_0051893	Biological process	regulation of focal adhesion assembly
GO_0150011	Biological process	regulation of neuron projection arborization
GO_0016055	Biological process	Wnt signaling pathway
GO_0010632	Biological process	regulation of epithelial cell migration
GO_0043001	Biological process	Golgi to plasma membrane protein transport
GO_0032587	Cellular component	ruffle membrane
GO_0005856	Cellular component	cytoskeleton
GO_0005886	Cellular component	plasma membrane
GO_0005874	Cellular component	microtubule
GO_0016020	Cellular component	membrane
GO_0005794	Cellular component	Golgi apparatus
GO_0005882	Cellular component	intermediate filament
GO_0015629	Cellular component	actin cytoskeleton
GO_0005737	Cellular component	cytoplasm
GO_0051011	Molecular function	microtubule minus-end binding
GO_0045296	Molecular function	cadherin binding
GO_0051015	Molecular function	actin filament binding
GO_0005198	Molecular function	structural molecule activity
GO_0008017	Molecular function	microtubule binding
GO_0003723	Molecular function	RNA binding
GO_0005509	Molecular function	calcium ion binding
GO_0005515	Molecular function	protein binding
GO_0003779	Molecular function	actin binding

IV. Literature review

[source]

Gene name	MACF1
Protein name	MACF1 protein Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) Microtubule-actin cross-linking factor 1, isoforms 6/7 (Uncharacterized protein KIAA0754) Macrophin 1 isoform Microtubule actin crosslinking factor 1 (cDNA FLJ59962, moderately similar to Microtubule-actin crosslinking factor 1(Actin cross-linking family 7)) Microtubule actin crosslinking factor 1
Synonyms	ACF7 KIAA0465 KIAA1251 ABP620 KIAA0754
Description	FUNCTION: [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules . Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex . Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration . May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 . Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). .
Accessions	O94854 E9PLY5 H0Y390 ENST00000360115.8 ENST00000422234.2 H3BPE1 E9PNZ4 ENST00000442046.5 A0A804HL78 ENST00000484793.5 ENST00000494012.1 H0Y6T5 ENST00000496804.5 A0A669KB06 Q8WXY3 H0Y4F5 ENST00000564288.6 B4DQX9 ENST00000672812.1 ENST00000673980.1 A0A669KB84 ENST00000602421.5 A0A590UJG2 H0Y314 ENST00000671089.2 ENST00000602528.2 ENST00000372915.8 A0A0A6YYJ5 ENST00000446276.5 Q32Q32 ENST00000673926.1 A0A8I5KY71 Q8WXY4 H0Y7I1 ENST00000690939.1 ENST00000530262.5 A0A5F9ZGX0 A0A7P0MQR8 A0A669KB76 A0A669KBB0 ENST00000567887.5 Q96IQ1 Q6IPG6 Q8WXX9 Q9UPN3 ENST00000530275.3 Q8WXY0 ENST00000673706.1 ENST00000524432.5 ENST00000372925.6 ENST00000361689.7 [Q9UPN3-2] E9PS75 E9PLY0 ENST00000683517.1 H3BQK9

MACF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review