KLF6 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	49 studies	57% ± 23%	Explore
endothelial cell	48 studies	51% ± 19%	Explore
natural killer cell	44 studies	53% ± 17%	Explore
fibroblast	44 studies	40% ± 17%	Explore
B cell	42 studies	58% ± 20%	Explore
T cell	41 studies	50% ± 20%	Explore
CD8-positive, alpha-beta T cell	41 studies	54% ± 17%	Explore
CD4-positive, alpha-beta T cell	38 studies	53% ± 22%	Explore
pericyte	36 studies	49% ± 21%	Explore
dendritic cell	33 studies	61% ± 26%	Explore
conventional dendritic cell	31 studies	65% ± 19%	Explore
smooth muscle cell	30 studies	44% ± 17%	Explore
endothelial cell of lymphatic vessel	28 studies	66% ± 21%	Explore
classical monocyte	28 studies	73% ± 16%	Explore
monocyte	27 studies	55% ± 21%	Explore
regulatory T cell	27 studies	66% ± 16%	Explore
mast cell	26 studies	59% ± 22%	Explore
non-classical monocyte	26 studies	73% ± 17%	Explore
plasmacytoid dendritic cell	25 studies	71% ± 17%	Explore
epithelial cell	23 studies	55% ± 20%	Explore
plasma cell	22 studies	48% ± 20%	Explore
mature NK T cell	22 studies	58% ± 16%	Explore
ciliated cell	21 studies	53% ± 23%	Explore
gamma-delta T cell	20 studies	61% ± 18%	Explore
memory B cell	20 studies	71% ± 16%	Explore
naive B cell	20 studies	55% ± 19%	Explore
basal cell	20 studies	55% ± 19%	Explore
myeloid cell	19 studies	59% ± 25%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	48% ± 16%	Explore
connective tissue cell	17 studies	40% ± 17%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	56% ± 18%	Explore
mucosal invariant T cell	15 studies	62% ± 17%	Explore
neutrophil	15 studies	55% ± 15%	Explore
capillary endothelial cell	15 studies	44% ± 16%	Explore
endothelial cell of vascular tree	15 studies	56% ± 13%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	47% ± 14%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	62% ± 16%	Explore
endothelial cell of artery	14 studies	47% ± 18%	Explore
myofibroblast cell	14 studies	43% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell	13 studies	59% ± 17%	Explore
CD4-positive, alpha-beta memory T cell	13 studies	65% ± 18%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	65% ± 17%	Explore
mesothelial cell	13 studies	49% ± 25%	Explore
vein endothelial cell	13 studies	49% ± 17%	Explore
type I pneumocyte	12 studies	68% ± 18%	Explore
secretory cell	12 studies	55% ± 21%	Explore
abnormal cell	11 studies	49% ± 26%	Explore
microglial cell	11 studies	35% ± 21%	Explore
type II pneumocyte	10 studies	46% ± 19%	Explore
plasmablast	10 studies	53% ± 16%	Explore
innate lymphoid cell	9 studies	56% ± 14%	Explore
leukocyte	9 studies	64% ± 16%	Explore
goblet cell	9 studies	56% ± 16%	Explore
T follicular helper cell	9 studies	65% ± 25%	Explore
alveolar macrophage	8 studies	63% ± 15%	Explore
club cell	8 studies	50% ± 22%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	53% ± 18%	Explore
mononuclear phagocyte	8 studies	59% ± 19%	Explore
progenitor cell	8 studies	46% ± 19%	Explore
enterocyte	8 studies	44% ± 19%	Explore
hematopoietic stem cell	8 studies	49% ± 17%	Explore
respiratory goblet cell	7 studies	35% ± 16%	Explore
platelet	7 studies	36% ± 12%	Explore
effector CD4-positive, alpha-beta T cell	7 studies	60% ± 19%	Explore
IgA plasma cell	7 studies	44% ± 12%	Explore
IgG plasma cell	7 studies	41% ± 18%	Explore
precursor B cell	7 studies	48% ± 16%	Explore
immature B cell	7 studies	57% ± 10%	Explore
CD4-positive helper T cell	6 studies	71% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	6 studies	61% ± 18%	Explore
hematopoietic precursor cell	6 studies	58% ± 19%	Explore
renal alpha-intercalated cell	6 studies	51% ± 19%	Explore
lymphocyte	6 studies	50% ± 29%	Explore
glial cell	6 studies	48% ± 22%	Explore
adipocyte	6 studies	31% ± 13%	Explore
intermediate monocyte	6 studies	71% ± 23%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	66% ± 16%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	65% ± 11%	Explore
exhausted T cell	5 studies	49% ± 8%	Explore
ionocyte	5 studies	38% ± 18%	Explore
endothelial cell of sinusoid	5 studies	27% ± 14%	Explore
erythrocyte	5 studies	44% ± 18%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	44% ± 16%	Explore
epithelial cell of proximal tubule	5 studies	42% ± 11%	Explore
transit amplifying cell	5 studies	38% ± 15%	Explore
pro-B cell	5 studies	47% ± 21%	Explore
T-helper 17 cell	5 studies	75% ± 23%	Explore
group 3 innate lymphoid cell	5 studies	82% ± 11%	Explore
neuron	5 studies	33% ± 12%	Explore
adventitial cell	5 studies	36% ± 14%	Explore
inflammatory macrophage	5 studies	57% ± 17%	Explore
double negative thymocyte	5 studies	62% ± 19%	Explore
myoepithelial cell	5 studies	53% ± 23%	Explore
hepatocyte	5 studies	43% ± 23%	Explore
granulocyte	5 studies	65% ± 8%	Explore
melanocyte	5 studies	52% ± 14%	Explore
keratinocyte	5 studies	50% ± 17%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	51% ± 19%	Explore
deuterosomal cell	4 studies	25% ± 6%	Explore
squamous epithelial cell	4 studies	52% ± 16%	Explore
pancreatic A cell	4 studies	39% ± 14%	Explore
monocyte-derived dendritic cell	4 studies	74% ± 13%	Explore
cholangiocyte	4 studies	45% ± 22%	Explore
parietal epithelial cell	4 studies	53% ± 10%	Explore
astrocyte	4 studies	29% ± 6%	Explore
kidney loop of Henle epithelial cell	4 studies	56% ± 16%	Explore
retinal rod cell	4 studies	26% ± 13%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	78% ± 8%	Explore
muscle cell	4 studies	37% ± 21%	Explore
glutamatergic neuron	4 studies	30% ± 6%	Explore
mucus secreting cell	4 studies	35% ± 12%	Explore
Schwann cell	4 studies	47% ± 14%	Explore
T-helper 1 cell	4 studies	76% ± 19%	Explore
Langerhans cell	3 studies	60% ± 17%	Explore
glomerular endothelial cell	3 studies	34% ± 10%	Explore
intestinal crypt stem cell	3 studies	43% ± 8%	Explore
retinal ganglion cell	3 studies	42% ± 19%	Explore
renal principal cell	3 studies	66% ± 16%	Explore
thymocyte	3 studies	49% ± 20%	Explore
extravillous trophoblast	3 studies	67% ± 9%	Explore
placental villous trophoblast	3 studies	21% ± 3%	Explore
brush cell	3 studies	35% ± 17%	Explore
duct epithelial cell	3 studies	36% ± 9%	Explore
cardiac muscle cell	3 studies	19% ± 3%	Explore
tissue-resident macrophage	3 studies	75% ± 27%	Explore
intraepithelial lymphocyte	3 studies	39% ± 11%	Explore
germinal center B cell	3 studies	41% ± 10%	Explore
luminal cell of prostate epithelium	3 studies	55% ± 4%	Explore
GABAergic neuron	3 studies	21% ± 4%	Explore
acinar cell	3 studies	56% ± 19%	Explore
pancreatic ductal cell	3 studies	79% ± 13%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	60% ± 9%	Explore
enteroendocrine cell	3 studies	54% ± 6%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	68% ± 18%	Explore
double-positive, alpha-beta thymocyte	3 studies	71% ± 14%	Explore
progenitor cell of mammary luminal epithelium	3 studies	79% ± 12%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	21 studies	52% ± 17%	Explore
peripheral blood	19 studies	60% ± 15%	Explore
intestine	14 studies	44% ± 20%	Explore
kidney	9 studies	43% ± 20%	Explore
liver	7 studies	37% ± 15%	Explore
lymph node	7 studies	49% ± 28%	Explore
uterus	6 studies	52% ± 18%	Explore
brain	6 studies	31% ± 10%	Explore
pancreas	5 studies	38% ± 10%	Explore
placenta	5 studies	42% ± 15%	Explore
eye	5 studies	28% ± 10%	Explore
skin	5 studies	49% ± 12%	Explore
breast	5 studies	61% ± 15%	Explore
bone marrow	4 studies	51% ± 20%	Explore
heart	4 studies	22% ± 3%	Explore
adipose	4 studies	42% ± 16%	Explore
esophagus	4 studies	47% ± 17%	Explore
prostate	4 studies	50% ± 12%	Explore
stomach	4 studies	26% ± 12%	Explore
ovary	3 studies	28% ± 7%	Explore
adrenal gland	3 studies	56% ± 23%	Explore
thymus	3 studies	46% ± 14%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	16761.71	1443 / 1445	100%	110.20	183 / 183
intestine	100%	16264.07	964 / 966	99%	107.99	523 / 527
breast	100%	30633.10	459 / 459	99%	114.64	1106 / 1118
bladder	100%	19634.67	21 / 21	99%	106.26	498 / 504
lung	100%	25916.02	578 / 578	99%	88.56	1140 / 1155
skin	100%	31644.33	1809 / 1809	95%	89.79	449 / 472
thymus	96%	15937.45	630 / 653	97%	140.97	586 / 605
uterus	98%	15811.53	167 / 170	95%	87.64	436 / 459
ovary	96%	9817.94	173 / 180	95%	73.29	410 / 430
kidney	92%	11946.35	82 / 89	98%	215.93	887 / 901
stomach	89%	12408.01	320 / 359	99%	104.47	284 / 286
pancreas	76%	7177.66	250 / 328	98%	133.21	174 / 178
prostate	76%	5998.90	187 / 245	87%	60.19	436 / 502
liver	61%	7958.23	138 / 226	86%	63.93	351 / 406
brain	12%	691.81	310 / 2642	90%	48.04	633 / 705
adipose	100%	38181.74	1204 / 1204	0%	0	0 / 0
spleen	100%	8957.80	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	83.43	45 / 45
ureter	0%	0	0 / 0	100%	22.57	1 / 1
blood vessel	100%	23137.86	1334 / 1335	0%	0	0 / 0
peripheral blood	96%	16155.45	893 / 929	0%	0	0 / 0
adrenal gland	30%	2171.11	77 / 258	63%	33.34	145 / 230
muscle	88%	11126.02	707 / 803	0%	0	0 / 0
lymph node	0%	0	0 / 0	79%	46.19	23 / 29
heart	76%	6135.21	655 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	71%	31.58	57 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0030183	Biological process	B cell differentiation
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0005730	Cellular component	nucleolus
GO_0001650	Cellular component	fibrillar center
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_1990837	Molecular function	sequence-specific double-stranded DNA binding
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228	Molecular function	DNA-binding transcription activator activity, RNA polymerase II-specific
GO_0005515	Molecular function	protein binding
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_0046872	Molecular function	metal ion binding

Gene name	KLF6
Protein name	Kruppel-like factor 6 variant SV2 Krueppel-like factor 6 (B-cell-derived protein 1) (Core promoter element-binding protein) (GC-rich sites-binding factor GBF) (Proto-oncogene BCD1) (Suppressor of tumorigenicity 12 protein) (Transcription factor Zf9)
Synonyms	ST12 CPBP BCD1 COPEB
Description	FUNCTION: Transcriptional activator (By similarity). Binds a GC box motif. Could play a role in B-cell growth and development. .
Accessions	ENST00000542957.1 [Q99612-3] D3GC14 Q99612 ENST00000469435.1 [Q99612-2] ENST00000497571.6 [Q99612-1]

KLF6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review