HNRNPC | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	49 studies	49% ± 18%	Explore
B cell	46 studies	54% ± 16%	Explore
fibroblast	45 studies	51% ± 18%	Explore
macrophage	43 studies	50% ± 17%	Explore
T cell	41 studies	49% ± 19%	Explore
natural killer cell	41 studies	53% ± 15%	Explore
CD8-positive, alpha-beta T cell	38 studies	52% ± 18%	Explore
pericyte	35 studies	48% ± 18%	Explore
CD4-positive, alpha-beta T cell	34 studies	56% ± 18%	Explore
smooth muscle cell	32 studies	47% ± 17%	Explore
conventional dendritic cell	29 studies	66% ± 15%	Explore
dendritic cell	27 studies	57% ± 20%	Explore
regulatory T cell	27 studies	55% ± 13%	Explore
classical monocyte	26 studies	54% ± 16%	Explore
endothelial cell of lymphatic vessel	25 studies	47% ± 16%	Explore
mast cell	24 studies	45% ± 19%	Explore
non-classical monocyte	24 studies	53% ± 13%	Explore
epithelial cell	24 studies	58% ± 23%	Explore
plasmacytoid dendritic cell	23 studies	61% ± 15%	Explore
basal cell	23 studies	56% ± 17%	Explore
monocyte	22 studies	54% ± 17%	Explore
plasma cell	21 studies	43% ± 16%	Explore
astrocyte	21 studies	38% ± 16%	Explore
mature NK T cell	20 studies	50% ± 12%	Explore
memory B cell	20 studies	57% ± 10%	Explore
gamma-delta T cell	19 studies	53% ± 16%	Explore
naive B cell	19 studies	50% ± 11%	Explore
ciliated cell	19 studies	54% ± 19%	Explore
connective tissue cell	19 studies	60% ± 23%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	18 studies	48% ± 12%	Explore
myeloid cell	18 studies	54% ± 21%	Explore
mucosal invariant T cell	17 studies	49% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	16 studies	53% ± 13%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	52% ± 14%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	15 studies	52% ± 15%	Explore
myofibroblast cell	15 studies	55% ± 21%	Explore
microglial cell	15 studies	44% ± 17%	Explore
oligodendrocyte	14 studies	37% ± 14%	Explore
oligodendrocyte precursor cell	14 studies	45% ± 21%	Explore
capillary endothelial cell	14 studies	41% ± 15%	Explore
endothelial cell of vascular tree	14 studies	52% ± 17%	Explore
effector memory CD8-positive, alpha-beta T cell	13 studies	50% ± 16%	Explore
CD4-positive, alpha-beta memory T cell	13 studies	53% ± 18%	Explore
endothelial cell of artery	13 studies	44% ± 15%	Explore
vein endothelial cell	13 studies	50% ± 17%	Explore
type II pneumocyte	12 studies	44% ± 17%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	58% ± 15%	Explore
secretory cell	12 studies	56% ± 16%	Explore
progenitor cell	12 studies	61% ± 25%	Explore
type I pneumocyte	11 studies	42% ± 18%	Explore
innate lymphoid cell	11 studies	53% ± 19%	Explore
plasmablast	11 studies	63% ± 20%	Explore
club cell	11 studies	46% ± 18%	Explore
leukocyte	11 studies	60% ± 12%	Explore
neuron	11 studies	54% ± 23%	Explore
goblet cell	11 studies	46% ± 21%	Explore
mesothelial cell	11 studies	60% ± 24%	Explore
neutrophil	10 studies	38% ± 14%	Explore
glutamatergic neuron	10 studies	47% ± 24%	Explore
abnormal cell	10 studies	59% ± 15%	Explore
GABAergic neuron	9 studies	43% ± 22%	Explore
epithelial cell of proximal tubule	9 studies	38% ± 20%	Explore
T follicular helper cell	9 studies	53% ± 15%	Explore
retinal rod cell	9 studies	58% ± 21%	Explore
adipocyte	9 studies	46% ± 17%	Explore
alveolar macrophage	8 studies	48% ± 16%	Explore
respiratory goblet cell	8 studies	43% ± 22%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	61% ± 16%	Explore
kidney loop of Henle epithelial cell	8 studies	38% ± 8%	Explore
renal alpha-intercalated cell	8 studies	43% ± 20%	Explore
retinal cone cell	8 studies	65% ± 22%	Explore
hematopoietic stem cell	8 studies	71% ± 22%	Explore
platelet	7 studies	28% ± 7%	Explore
mononuclear phagocyte	7 studies	56% ± 20%	Explore
kidney distal convoluted tubule epithelial cell	7 studies	55% ± 25%	Explore
IgG plasma cell	7 studies	24% ± 10%	Explore
interneuron	7 studies	55% ± 21%	Explore
precursor B cell	7 studies	65% ± 21%	Explore
immature B cell	7 studies	58% ± 21%	Explore
amacrine cell	7 studies	47% ± 18%	Explore
erythrocyte	7 studies	52% ± 20%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	6 studies	42% ± 11%	Explore
ionocyte	6 studies	33% ± 11%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	64% ± 11%	Explore
enterocyte	6 studies	35% ± 19%	Explore
transit amplifying cell	6 studies	49% ± 19%	Explore
retinal ganglion cell	6 studies	40% ± 20%	Explore
lymphocyte	6 studies	58% ± 18%	Explore
retina horizontal cell	6 studies	49% ± 16%	Explore
cardiac muscle cell	6 studies	35% ± 6%	Explore
Mueller cell	6 studies	46% ± 8%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	63% ± 11%	Explore
hepatocyte	6 studies	59% ± 30%	Explore
CD4-positive helper T cell	5 studies	43% ± 18%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	48% ± 14%	Explore
hematopoietic precursor cell	5 studies	87% ± 11%	Explore
exhausted T cell	5 studies	62% ± 13%	Explore
enteroendocrine cell	5 studies	61% ± 24%	Explore
erythroblast	5 studies	65% ± 28%	Explore
intestinal crypt stem cell	5 studies	47% ± 18%	Explore
retinal bipolar neuron	5 studies	51% ± 18%	Explore
glial cell	5 studies	44% ± 25%	Explore
OFF-bipolar cell	5 studies	42% ± 13%	Explore
ON-bipolar cell	5 studies	42% ± 16%	Explore
renal principal cell	5 studies	42% ± 11%	Explore
pro-B cell	5 studies	72% ± 21%	Explore
brush cell	5 studies	39% ± 25%	Explore
T-helper 17 cell	5 studies	66% ± 19%	Explore
group 3 innate lymphoid cell	5 studies	76% ± 6%	Explore
retinal pigment epithelial cell	5 studies	54% ± 17%	Explore
adventitial cell	5 studies	36% ± 11%	Explore
muscle cell	5 studies	48% ± 20%	Explore
double negative thymocyte	5 studies	66% ± 15%	Explore
IgA plasma cell	5 studies	30% ± 12%	Explore
granulocyte	5 studies	59% ± 16%	Explore
mucus secreting cell	5 studies	27% ± 7%	Explore
deuterosomal cell	4 studies	43% ± 9%	Explore
duct epithelial cell	4 studies	32% ± 11%	Explore
precursor cell	4 studies	70% ± 16%	Explore
squamous epithelial cell	4 studies	37% ± 26%	Explore
pancreatic A cell	4 studies	71% ± 13%	Explore
type B pancreatic cell	4 studies	66% ± 23%	Explore
glomerular endothelial cell	4 studies	42% ± 10%	Explore
podocyte	4 studies	58% ± 27%	Explore
granule cell	4 studies	32% ± 8%	Explore
GABAergic amacrine cell	4 studies	39% ± 11%	Explore
glycinergic amacrine cell	4 studies	43% ± 7%	Explore
megakaryocyte	4 studies	42% ± 23%	Explore
inflammatory macrophage	4 studies	45% ± 12%	Explore
acinar cell	4 studies	51% ± 24%	Explore
chondrocyte	4 studies	47% ± 14%	Explore
germinal center B cell	4 studies	64% ± 14%	Explore
intermediate monocyte	4 studies	56% ± 22%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	71% ± 2%	Explore
myoepithelial cell	4 studies	58% ± 11%	Explore
luminal cell of prostate epithelium	4 studies	45% ± 11%	Explore
keratinocyte	4 studies	48% ± 16%	Explore
T-helper 1 cell	4 studies	65% ± 14%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	54% ± 23%	Explore
hillock cell	3 studies	40% ± 9%	Explore
pancreatic D cell	3 studies	69% ± 21%	Explore
monocyte-derived dendritic cell	3 studies	70% ± 10%	Explore
parietal epithelial cell	3 studies	43% ± 14%	Explore
neural crest cell	3 studies	84% ± 11%	Explore
extravillous trophoblast	3 studies	80% ± 11%	Explore
placental villous trophoblast	3 studies	91% ± 3%	Explore
neuroendocrine cell	3 studies	59% ± 17%	Explore
Schwann cell	3 studies	59% ± 17%	Explore
tissue-resident macrophage	3 studies	63% ± 11%	Explore
intraepithelial lymphocyte	3 studies	51% ± 23%	Explore
rod bipolar cell	3 studies	60% ± 2%	Explore
endothelial cell of sinusoid	3 studies	27% ± 6%	Explore
cholangiocyte	3 studies	67% ± 10%	Explore
IgM plasma cell	3 studies	36% ± 14%	Explore
pancreatic ductal cell	3 studies	82% ± 11%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	96% ± 2%	Explore
melanocyte	3 studies	43% ± 16%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	54% ± 3%	Explore
double-positive, alpha-beta thymocyte	3 studies	71% ± 14%	Explore
progenitor cell of mammary luminal epithelium	3 studies	57% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	21 studies	50% ± 17%	Explore
brain	21 studies	40% ± 18%	Explore
peripheral blood	19 studies	53% ± 14%	Explore
intestine	12 studies	44% ± 21%	Explore
eye	12 studies	52% ± 15%	Explore
kidney	11 studies	46% ± 15%	Explore
liver	7 studies	54% ± 19%	Explore
lymph node	6 studies	51% ± 17%	Explore
heart	6 studies	33% ± 8%	Explore
pancreas	5 studies	61% ± 22%	Explore
uterus	5 studies	63% ± 15%	Explore
adipose	5 studies	36% ± 12%	Explore
prostate	5 studies	52% ± 18%	Explore
placenta	4 studies	69% ± 22%	Explore
bone marrow	4 studies	61% ± 17%	Explore
esophagus	4 studies	47% ± 27%	Explore
breast	4 studies	57% ± 7%	Explore
adrenal gland	3 studies	48% ± 10%	Explore
skin	3 studies	45% ± 7%	Explore
stomach	3 studies	42% ± 29%	Explore
thymus	3 studies	74% ± 23%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	18254.31	459 / 459	100%	237.60	1118 / 1118
esophagus	100%	15619.24	1445 / 1445	100%	137.62	183 / 183
lung	100%	17547.20	578 / 578	100%	180.69	1155 / 1155
ovary	100%	24021.13	180 / 180	100%	187.66	430 / 430
prostate	100%	16459.61	245 / 245	100%	188.63	502 / 502
uterus	100%	19753.23	170 / 170	100%	213.83	459 / 459
brain	100%	13495.48	2641 / 2642	100%	203.28	705 / 705
intestine	100%	16132.83	966 / 966	100%	158.43	526 / 527
bladder	100%	17795.24	21 / 21	100%	172.38	503 / 504
skin	100%	20918.66	1809 / 1809	100%	170.45	471 / 472
thymus	100%	15155.59	653 / 653	100%	194.83	603 / 605
stomach	100%	12456.49	359 / 359	100%	136.60	285 / 286
liver	100%	10660.96	226 / 226	100%	106.06	404 / 406
kidney	100%	16452.10	89 / 89	99%	136.52	895 / 901
adrenal gland	100%	19137.46	258 / 258	99%	123.54	227 / 230
pancreas	100%	9171.74	327 / 328	99%	141.60	176 / 178
adipose	100%	17247.33	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	271.55	29 / 29
spleen	100%	20115.17	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	184.12	45 / 45
ureter	0%	0	0 / 0	100%	87.17	1 / 1
blood vessel	100%	14765.22	1334 / 1335	0%	0	0 / 0
muscle	100%	10662.43	801 / 803	0%	0	0 / 0
peripheral blood	99%	24156.13	922 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	99%	157.32	79 / 80
heart	98%	9958.74	842 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0001649	Biological process	osteoblast differentiation
GO_0006338	Biological process	chromatin remodeling
GO_0000398	Biological process	mRNA splicing, via spliceosome
GO_0032211	Biological process	negative regulation of telomere maintenance via telomerase
GO_0008380	Biological process	RNA splicing
GO_0070935	Biological process	3'-UTR-mediated mRNA stabilization
GO_0005576	Cellular component	extracellular region
GO_0005681	Cellular component	spliceosomal complex
GO_0016020	Cellular component	membrane
GO_0070062	Cellular component	extracellular exosome
GO_0032991	Cellular component	protein-containing complex
GO_0005654	Cellular component	nucleoplasm
GO_0005697	Cellular component	telomerase holoenzyme complex
GO_0015629	Cellular component	actin cytoskeleton
GO_0005829	Cellular component	cytosol
GO_0071013	Cellular component	catalytic step 2 spliceosome
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_0031492	Molecular function	nucleosomal DNA binding
GO_0042802	Molecular function	identical protein binding
GO_0008266	Molecular function	poly(U) RNA binding
GO_1990247	Molecular function	N6-methyladenosine-containing RNA reader activity
GO_0070034	Molecular function	telomerase RNA binding
GO_0003723	Molecular function	RNA binding
GO_0003730	Molecular function	mRNA 3'-UTR binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	HNRNPC
Protein name	Heterogeneous nuclear ribonucleoprotein C (cDNA FLJ53542, highly similar to Heterogeneous nuclear ribonucleoproteins C) Heterogeneous nuclear ribonucleoprotein C Heterogeneous nuclear ribonucleoprotein C (cDNA FLJ52975, highly similar to Heterogeneous nuclear ribonucleoproteins C) Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1/C2)
Synonyms	HNRPC
Description	FUNCTION: Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles . Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules . Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides . May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing . .
Accessions	ENST00000554455.5 [P07910-1] G3V251 ENST00000553300.6 [P07910-2] ENST00000557201.5 [P07910-1] P07910 ENST00000430246.6 [P07910-2] B4DSU6 ENST00000554539.5 ENST00000554891.5 ENST00000336053.10 ENST00000553753.5 G3V4M8 G3V2H6 ENST00000556226.5 ENST00000420743.6 [P07910-1] ENST00000556628.5 [P07910-3] G3V5V7 ENST00000556897.5 [P07910-2] ENST00000555883.5 [P07910-4] ENST00000557442.5 G3V555 ENST00000555914.5 ENST00000555176.5 ENST00000555309.5 G3V3K6 G3V2D6 G3V576 ENST00000554969.5 [P07910-2] ENST00000557157.5 B4DY08 ENST00000555137.5 ENST00000556513.5 ENST00000557336.1 G3V575 G3V2Q1 G3V5X6 G3V4C1 G3V4W0 ENST00000555215.5 ENST00000554383.5 ENST00000557768.1 ENST00000556142.5

HNRNPC report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review