HNRNPA1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	49 studies	74% ± 22%	Explore
natural killer cell	44 studies	76% ± 21%	Explore
macrophage	40 studies	63% ± 24%	Explore
fibroblast	40 studies	69% ± 26%	Explore
T cell	39 studies	71% ± 26%	Explore
endothelial cell	39 studies	62% ± 25%	Explore
CD8-positive, alpha-beta T cell	38 studies	74% ± 23%	Explore
CD4-positive, alpha-beta T cell	34 studies	82% ± 19%	Explore
pericyte	30 studies	74% ± 24%	Explore
dendritic cell	29 studies	71% ± 27%	Explore
conventional dendritic cell	29 studies	87% ± 11%	Explore
plasmacytoid dendritic cell	28 studies	85% ± 15%	Explore
regulatory T cell	27 studies	85% ± 14%	Explore
smooth muscle cell	26 studies	77% ± 22%	Explore
classical monocyte	26 studies	70% ± 12%	Explore
non-classical monocyte	24 studies	78% ± 13%	Explore
mast cell	23 studies	59% ± 25%	Explore
epithelial cell	23 studies	74% ± 20%	Explore
plasma cell	22 studies	65% ± 20%	Explore
endothelial cell of lymphatic vessel	22 studies	74% ± 20%	Explore
monocyte	21 studies	70% ± 20%	Explore
mature NK T cell	21 studies	74% ± 20%	Explore
basal cell	21 studies	75% ± 20%	Explore
gamma-delta T cell	20 studies	79% ± 18%	Explore
memory B cell	20 studies	87% ± 9%	Explore
naive B cell	19 studies	84% ± 10%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	18 studies	83% ± 16%	Explore
connective tissue cell	18 studies	82% ± 17%	Explore
mucosal invariant T cell	16 studies	82% ± 17%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	15 studies	88% ± 17%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	79% ± 14%	Explore
ciliated cell	15 studies	58% ± 16%	Explore
myofibroblast cell	15 studies	75% ± 27%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	80% ± 18%	Explore
myeloid cell	14 studies	67% ± 24%	Explore
CD4-positive, alpha-beta memory T cell	13 studies	75% ± 20%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	75% ± 22%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	72% ± 20%	Explore
innate lymphoid cell	12 studies	81% ± 14%	Explore
plasmablast	12 studies	78% ± 18%	Explore
secretory cell	12 studies	72% ± 20%	Explore
capillary endothelial cell	12 studies	56% ± 20%	Explore
endothelial cell of artery	12 studies	63% ± 19%	Explore
vein endothelial cell	12 studies	68% ± 20%	Explore
type I pneumocyte	11 studies	50% ± 27%	Explore
progenitor cell	11 studies	79% ± 28%	Explore
endothelial cell of vascular tree	11 studies	81% ± 13%	Explore
type II pneumocyte	10 studies	66% ± 28%	Explore
T follicular helper cell	10 studies	88% ± 10%	Explore
club cell	10 studies	55% ± 27%	Explore
abnormal cell	10 studies	74% ± 24%	Explore
goblet cell	10 studies	60% ± 19%	Explore
mesothelial cell	10 studies	83% ± 19%	Explore
microglial cell	10 studies	46% ± 27%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	76% ± 20%	Explore
leukocyte	8 studies	81% ± 13%	Explore
neutrophil	8 studies	48% ± 24%	Explore
IgG plasma cell	8 studies	50% ± 21%	Explore
hematopoietic stem cell	8 studies	97% ± 4%	Explore
erythrocyte	8 studies	65% ± 22%	Explore
platelet	7 studies	46% ± 19%	Explore
mononuclear phagocyte	7 studies	63% ± 25%	Explore
epithelial cell of proximal tubule	7 studies	66% ± 18%	Explore
IgA plasma cell	7 studies	53% ± 24%	Explore
astrocyte	7 studies	32% ± 20%	Explore
precursor B cell	7 studies	86% ± 22%	Explore
alveolar macrophage	6 studies	59% ± 19%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	82% ± 14%	Explore
kidney loop of Henle epithelial cell	6 studies	66% ± 13%	Explore
renal alpha-intercalated cell	6 studies	88% ± 8%	Explore
megakaryocyte	6 studies	54% ± 24%	Explore
enterocyte	6 studies	57% ± 17%	Explore
enteroendocrine cell	6 studies	70% ± 27%	Explore
intestinal crypt stem cell	6 studies	75% ± 25%	Explore
transit amplifying cell	6 studies	67% ± 23%	Explore
glutamatergic neuron	6 studies	31% ± 11%	Explore
amacrine cell	6 studies	51% ± 28%	Explore
retinal ganglion cell	6 studies	63% ± 34%	Explore
retinal rod cell	6 studies	43% ± 23%	Explore
brush cell	6 studies	62% ± 29%	Explore
immature B cell	6 studies	93% ± 6%	Explore
neuron	6 studies	73% ± 27%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	84% ± 11%	Explore
CD4-positive helper T cell	5 studies	72% ± 15%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	84% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	78% ± 8%	Explore
hematopoietic precursor cell	5 studies	88% ± 17%	Explore
exhausted T cell	5 studies	84% ± 11%	Explore
ionocyte	5 studies	62% ± 4%	Explore
respiratory goblet cell	5 studies	52% ± 23%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	82% ± 15%	Explore
erythroblast	5 studies	77% ± 15%	Explore
OFF-bipolar cell	5 studies	51% ± 29%	Explore
ON-bipolar cell	5 studies	47% ± 30%	Explore
retinal cone cell	5 studies	55% ± 30%	Explore
pro-B cell	5 studies	83% ± 26%	Explore
neuroendocrine cell	5 studies	70% ± 15%	Explore
T-helper 17 cell	5 studies	89% ± 13%	Explore
group 3 innate lymphoid cell	5 studies	93% ± 4%	Explore
retina horizontal cell	5 studies	43% ± 26%	Explore
mucus secreting cell	5 studies	46% ± 24%	Explore
double negative thymocyte	5 studies	92% ± 4%	Explore
intermediate monocyte	5 studies	79% ± 17%	Explore
granulocyte	5 studies	76% ± 13%	Explore
oligodendrocyte precursor cell	5 studies	53% ± 29%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	63% ± 26%	Explore
duct epithelial cell	4 studies	75% ± 9%	Explore
precursor cell	4 studies	78% ± 28%	Explore
pancreatic A cell	4 studies	80% ± 10%	Explore
type B pancreatic cell	4 studies	77% ± 15%	Explore
glomerular endothelial cell	4 studies	49% ± 19%	Explore
podocyte	4 studies	78% ± 22%	Explore
retinal bipolar neuron	4 studies	60% ± 32%	Explore
GABAergic amacrine cell	4 studies	39% ± 21%	Explore
glycinergic amacrine cell	4 studies	37% ± 19%	Explore
lymphocyte	4 studies	87% ± 7%	Explore
adventitial cell	4 studies	66% ± 14%	Explore
Mueller cell	4 studies	45% ± 16%	Explore
acinar cell	4 studies	78% ± 4%	Explore
oligodendrocyte	4 studies	25% ± 7%	Explore
germinal center B cell	4 studies	92% ± 4%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	87% ± 10%	Explore
luminal cell of prostate epithelium	4 studies	55% ± 24%	Explore
GABAergic neuron	4 studies	28% ± 7%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	82% ± 29%	Explore
glial cell	4 studies	57% ± 29%	Explore
hepatocyte	4 studies	44% ± 21%	Explore
keratinocyte	4 studies	68% ± 28%	Explore
T-helper 1 cell	4 studies	90% ± 8%	Explore
interneuron	4 studies	52% ± 25%	Explore
deuterosomal cell	3 studies	68% ± 0%	Explore
hillock cell	3 studies	62% ± 26%	Explore
pancreatic D cell	3 studies	86% ± 11%	Explore
monocyte-derived dendritic cell	3 studies	86% ± 15%	Explore
kidney connecting tubule epithelial cell	3 studies	80% ± 14%	Explore
renal beta-intercalated cell	3 studies	98% ± 1%	Explore
neural crest cell	3 studies	98% ± 3%	Explore
paneth cell	3 studies	67% ± 17%	Explore
renal principal cell	3 studies	74% ± 11%	Explore
thymocyte	3 studies	81% ± 15%	Explore
common myeloid progenitor	3 studies	66% ± 35%	Explore
chondrocyte	3 studies	84% ± 14%	Explore
retinal pigment epithelial cell	3 studies	66% ± 26%	Explore
serous secreting cell	3 studies	63% ± 3%	Explore
tissue-resident macrophage	3 studies	61% ± 27%	Explore
follicular B cell	3 studies	75% ± 15%	Explore
intraepithelial lymphocyte	3 studies	78% ± 14%	Explore
rod bipolar cell	3 studies	54% ± 23%	Explore
muscle cell	3 studies	54% ± 15%	Explore
myoepithelial cell	3 studies	94% ± 2%	Explore
inflammatory macrophage	3 studies	60% ± 19%	Explore
IgM plasma cell	3 studies	63% ± 22%	Explore
pancreatic ductal cell	3 studies	86% ± 3%	Explore
neural progenitor cell	3 studies	46% ± 22%	Explore
granulocyte monocyte progenitor cell	3 studies	69% ± 32%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	95% ± 1%	Explore
double-positive, alpha-beta thymocyte	3 studies	97% ± 1%	Explore
progenitor cell of mammary luminal epithelium	3 studies	92% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	21 studies	78% ± 18%	Explore
lung	19 studies	65% ± 19%	Explore
intestine	14 studies	63% ± 27%	Explore
kidney	9 studies	70% ± 20%	Explore
eye	9 studies	56% ± 20%	Explore
brain	9 studies	43% ± 16%	Explore
bone marrow	6 studies	62% ± 24%	Explore
lymph node	6 studies	86% ± 6%	Explore
liver	6 studies	58% ± 15%	Explore
pancreas	5 studies	75% ± 15%	Explore
uterus	5 studies	80% ± 15%	Explore
prostate	5 studies	58% ± 31%	Explore
breast	4 studies	82% ± 7%	Explore
placenta	3 studies	79% ± 17%	Explore
heart	3 studies	39% ± 15%	Explore
adrenal gland	3 studies	63% ± 27%	Explore
esophagus	3 studies	69% ± 21%	Explore
skin	3 studies	73% ± 11%	Explore
thymus	3 studies	81% ± 25%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	35010.79	1445 / 1445	100%	265.46	183 / 183
ovary	100%	103335.81	180 / 180	100%	273.26	430 / 430
pancreas	100%	29853.40	328 / 328	100%	244.41	178 / 178
stomach	100%	30155.15	359 / 359	100%	298.68	286 / 286
uterus	100%	56200.43	170 / 170	100%	351.84	459 / 459
intestine	100%	38041.91	966 / 966	100%	348.83	526 / 527
bladder	100%	43500.86	21 / 21	100%	316.52	503 / 504
prostate	100%	39850.51	245 / 245	100%	300.77	501 / 502
skin	100%	46765.89	1809 / 1809	100%	298.74	471 / 472
lung	100%	34942.51	578 / 578	100%	264.33	1152 / 1155
brain	100%	24948.14	2635 / 2642	100%	307.67	705 / 705
thymus	100%	36800.86	653 / 653	100%	320.39	603 / 605
breast	100%	45357.49	459 / 459	99%	309.79	1111 / 1118
adrenal gland	100%	33523.76	258 / 258	99%	221.88	228 / 230
kidney	100%	32332.01	89 / 89	99%	232.18	891 / 901
liver	98%	12760.27	222 / 226	96%	142.54	389 / 406
adipose	100%	42076.27	1204 / 1204	0%	0	0 / 0
blood vessel	100%	34271.69	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	337.66	80 / 80
lymph node	0%	0	0 / 0	100%	488.28	29 / 29
spleen	100%	35527.15	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	301.05	45 / 45
ureter	0%	0	0 / 0	100%	196.38	1 / 1
muscle	100%	23173.81	801 / 803	0%	0	0 / 0
heart	97%	20693.87	836 / 861	0%	0	0 / 0
peripheral blood	91%	30119.84	842 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_1903936	Biological process	cellular response to sodium arsenite
GO_0042149	Biological process	cellular response to glucose starvation
GO_0006405	Biological process	RNA export from nucleus
GO_0051170	Biological process	import into nucleus
GO_0051028	Biological process	mRNA transport
GO_0051168	Biological process	nuclear export
GO_0000381	Biological process	regulation of alternative mRNA splicing, via spliceosome
GO_0000398	Biological process	mRNA splicing, via spliceosome
GO_0032211	Biological process	negative regulation of telomere maintenance via telomerase
GO_0043484	Biological process	regulation of RNA splicing
GO_0032212	Biological process	positive regulation of telomere maintenance via telomerase
GO_0005681	Cellular component	spliceosomal complex
GO_0016020	Cellular component	membrane
GO_0070062	Cellular component	extracellular exosome
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_1990904	Cellular component	ribonucleoprotein complex
GO_0071013	Cellular component	catalytic step 2 spliceosome
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0061752	Molecular function	telomeric repeat-containing RNA binding
GO_0019904	Molecular function	protein domain specific binding
GO_0003727	Molecular function	single-stranded RNA binding
GO_0003697	Molecular function	single-stranded DNA binding
GO_0003723	Molecular function	RNA binding
GO_0098505	Molecular function	G-rich strand telomeric DNA binding
GO_0036002	Molecular function	pre-mRNA binding
GO_0003730	Molecular function	mRNA 3'-UTR binding
GO_0035198	Molecular function	miRNA binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	HNRNPA1
Protein name	Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed] Heterogeneous nuclear ribonucleoprotein A1
Synonyms	HNRPA1
Description	FUNCTION: Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection . Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform . Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1 . May bind to specific miRNA hairpins . .; FUNCTION: (Microbial infection) May play a role in HCV RNA replication. .; FUNCTION: (Microbial infection) Cleavage by Enterovirus 71 protease 3C results in increased translation of apoptosis protease activating factor APAF1, leading to apoptosis. .
Accessions	ENST00000678581.1 ENST00000677279.1 ENST00000679273.1 ENST00000677220.1 A0A7I2V360 A0A7I2V4E2 ENST00000676472.1 ENST00000676572.1 ENST00000550482 ENST00000677847.1 A0A7I2V661 ENST00000679026.1 ENST00000676661.1 ENST00000677488.1 ENST00000676853.1 ENST00000677072.1 F8W6I7 A0A7I2V5P1 A0A7I2YQX9 A0A7I2V5H0 A0A7I2V453 A0A7I2YQV6 ENST00000678424.1 F8VTQ5 A0A7I2V2Z4 ENST00000679251.1 A0A7I2V3U9 ENST00000676794.1 ENST00000678456.1 A0A7I2YQU4 ENST00000676886.1 A0A7I2V5N7 ENST00000678919.1 A0A7I2V3S1 ENST00000678934.1 A0A7I2V2W8 ENST00000677291.1 ENST00000677645.1 ENST00000678873.1 ENST00000676707.1 ENST00000547566.5 [P09651-2] A0A7I2V595 A0A7I2YQW0 ENST00000677385.1 ENST00000678513.1 A0A7I2V497 A0A7I2V520 A0A7I2V459 A0A7I2YQ85 ENST00000677375.1 A0A7I2V3F4 A0A7I2V3J5 A0A7I2V5U9 A0A7I2V5T1 A0A7I2V2R4 A0A7I2V2F1 A0A7I2V3C7 ENST00000677636.1 ENST00000677666.1 ENST00000547708.5 A0A7I2YQR6 ENST00000678690.1 ENST00000677210.1 [P09651-1] ENST00000548688.5 A0A7I2V666 A0A7I2V3K5 ENST00000679079.1 A0A7I2YQY2 A0A7I2YQJ2 ENST00000677539.1 ENST00000330752 ENST00000676951.1 A0A7I2V4F8 A0A7I2V2M7 ENST00000678077.1 A0A7I2V3U8 ENST00000677518.1 ENST00000678611.1 ENST00000677191.1 A0A7I2V3W4 ENST00000677778.1 ENST00000677249.1 ENST00000678876.1 ENST00000678347.1 F8VZ49 ENST00000678970.1 A0A7I2V5W8 ENST00000678199.1 ENST00000678597.1 A0A7I2V4R7 A0A7I2V2Q7 A0A7I2V4P7 ENST00000678947.1 A0A7I2V4M0 ENST00000677061.1 A0A7I2V334 A0A7I2V5L7 A0A7I2V3R8 ENST00000551702.5 H0YH80 ENST00000340913.11 [P09651-1] F8W646 P09651 A0A7I2YQV3 ENST00000679101.1 F8VYN5 ENST00000678412.1 ENST00000547276.5 [P09651-3] A0A7I2V2L6 ENST00000677945.1 ENST00000550994.2 ENST00000679063.1 ENST00000676925.1 ENST00000546500.5 [P09651-2] ENST00000677832.1 ENST00000678448.1 A0A7I2V2X1 A0A7I2V3W0 ENST00000678212.1 A0A7I2V434 ENST00000550482.2 [P09651-2] ENST00000676842.1 ENST00000677840.1 ENST00000677224.1 ENST00000679344.1

HNRNPA1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review