H3-3A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008283Biological processcell population proliferation
GO_0030307Biological processpositive regulation of cell growth
GO_1902340Biological processnegative regulation of chromosome condensation
GO_0042692Biological processmuscle cell differentiation
GO_0001649Biological processosteoblast differentiation
GO_0035264Biological processmulticellular organism growth
GO_0006334Biological processnucleosome assembly
GO_0001556Biological processoocyte maturation
GO_0006997Biological processnucleus organization
GO_0031509Biological processsubtelomeric heterochromatin formation
GO_0090230Biological processregulation of centromere complex assembly
GO_0008584Biological processmale gonad development
GO_0032200Biological processtelomere organization
GO_0007338Biological processsingle fertilization
GO_0031508Biological processpericentric heterochromatin formation
GO_0007286Biological processspermatid development
GO_0007566Biological processembryo implantation
GO_0005576Cellular componentextracellular region
GO_0000786Cellular componentnucleosome
GO_0000939Cellular componentinner kinetochore
GO_0070062Cellular componentextracellular exosome
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0001740Cellular componentBarr body
GO_0000781Cellular componentchromosome, telomeric region
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0031492Molecular functionnucleosomal DNA binding
GO_0030527Molecular functionstructural constituent of chromatin
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005515Molecular functionprotein binding
GO_0000979Molecular functionRNA polymerase II core promoter sequence-specific DNA binding

IV. Literature review

[source]
Gene nameH3-3A
Protein nameHistone H3.3
Histone H3
SynonymsH3F3A
H3.3B
H3-3B
H3F3B
H3F3
H3.3A
PP781;
DescriptionFUNCTION: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. .

FUNCTION: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. .

AccessionsENST00000366815.10
ENST00000366814.3
ENST00000666609.1
ENST00000586607.5
ENST00000589599.5
ENST00000661429.1
ENST00000254810.8
ENST00000366813.1
ENST00000667897.1
B4DEB1
ENST00000366816.5
ENST00000655399.1
ENST00000587560.5
A0A590UJJ6
P84243