EIF4G2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	44 studies	51% ± 20%	Explore
macrophage	43 studies	45% ± 16%	Explore
B cell	41 studies	45% ± 14%	Explore
natural killer cell	39 studies	43% ± 13%	Explore
fibroblast	39 studies	48% ± 19%	Explore
T cell	36 studies	41% ± 18%	Explore
pericyte	35 studies	53% ± 21%	Explore
CD8-positive, alpha-beta T cell	35 studies	42% ± 14%	Explore
CD4-positive, alpha-beta T cell	32 studies	44% ± 15%	Explore
smooth muscle cell	29 studies	52% ± 19%	Explore
classical monocyte	28 studies	52% ± 16%	Explore
conventional dendritic cell	28 studies	51% ± 16%	Explore
regulatory T cell	26 studies	47% ± 14%	Explore
non-classical monocyte	25 studies	54% ± 14%	Explore
dendritic cell	24 studies	51% ± 21%	Explore
epithelial cell	23 studies	53% ± 19%	Explore
monocyte	22 studies	45% ± 16%	Explore
plasmacytoid dendritic cell	22 studies	59% ± 16%	Explore
endothelial cell of lymphatic vessel	21 studies	44% ± 17%	Explore
basal cell	21 studies	54% ± 16%	Explore
mast cell	20 studies	39% ± 17%	Explore
memory B cell	20 studies	50% ± 9%	Explore
naive B cell	20 studies	45% ± 10%	Explore
plasma cell	19 studies	38% ± 16%	Explore
gamma-delta T cell	19 studies	47% ± 16%	Explore
connective tissue cell	19 studies	51% ± 17%	Explore
mature NK T cell	18 studies	41% ± 10%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	39% ± 11%	Explore
ciliated cell	17 studies	59% ± 16%	Explore
myeloid cell	16 studies	49% ± 22%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	46% ± 14%	Explore
mucosal invariant T cell	15 studies	45% ± 14%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	15 studies	41% ± 10%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	47% ± 11%	Explore
capillary endothelial cell	14 studies	47% ± 16%	Explore
myofibroblast cell	14 studies	54% ± 17%	Explore
CD4-positive, alpha-beta memory T cell	13 studies	47% ± 12%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	50% ± 14%	Explore
endothelial cell of artery	13 studies	54% ± 20%	Explore
endothelial cell of vascular tree	13 studies	51% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	44% ± 13%	Explore
secretory cell	12 studies	56% ± 9%	Explore
astrocyte	12 studies	29% ± 12%	Explore
vein endothelial cell	12 studies	52% ± 16%	Explore
type I pneumocyte	11 studies	46% ± 20%	Explore
plasmablast	11 studies	56% ± 23%	Explore
platelet	11 studies	39% ± 11%	Explore
type II pneumocyte	10 studies	50% ± 20%	Explore
progenitor cell	10 studies	49% ± 17%	Explore
neuron	10 studies	49% ± 26%	Explore
goblet cell	10 studies	38% ± 13%	Explore
mesothelial cell	10 studies	48% ± 22%	Explore
glutamatergic neuron	10 studies	36% ± 17%	Explore
club cell	9 studies	47% ± 17%	Explore
leukocyte	9 studies	42% ± 11%	Explore
neutrophil	9 studies	30% ± 11%	Explore
abnormal cell	9 studies	53% ± 12%	Explore
innate lymphoid cell	8 studies	48% ± 12%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	49% ± 9%	Explore
T follicular helper cell	8 studies	48% ± 9%	Explore
microglial cell	8 studies	30% ± 11%	Explore
oligodendrocyte precursor cell	8 studies	39% ± 16%	Explore
oligodendrocyte	8 studies	27% ± 8%	Explore
alveolar macrophage	7 studies	47% ± 13%	Explore
epithelial cell of proximal tubule	7 studies	38% ± 10%	Explore
interneuron	7 studies	39% ± 16%	Explore
hematopoietic stem cell	7 studies	50% ± 7%	Explore
precursor B cell	7 studies	66% ± 16%	Explore
brush cell	7 studies	49% ± 21%	Explore
immature B cell	7 studies	58% ± 12%	Explore
ionocyte	6 studies	56% ± 9%	Explore
respiratory goblet cell	6 studies	53% ± 16%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	47% ± 8%	Explore
mononuclear phagocyte	6 studies	50% ± 12%	Explore
kidney loop of Henle epithelial cell	6 studies	39% ± 7%	Explore
megakaryocyte	6 studies	62% ± 23%	Explore
enterocyte	6 studies	30% ± 8%	Explore
IgG plasma cell	6 studies	30% ± 13%	Explore
transit amplifying cell	6 studies	38% ± 16%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	50% ± 12%	Explore
GABAergic neuron	6 studies	40% ± 6%	Explore
CD4-positive helper T cell	5 studies	41% ± 16%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	45% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	39% ± 8%	Explore
hematopoietic precursor cell	5 studies	61% ± 10%	Explore
exhausted T cell	5 studies	50% ± 10%	Explore
renal alpha-intercalated cell	5 studies	55% ± 10%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	55% ± 10%	Explore
enteroendocrine cell	5 studies	52% ± 19%	Explore
erythroblast	5 studies	51% ± 26%	Explore
lymphocyte	5 studies	46% ± 22%	Explore
pro-B cell	5 studies	62% ± 18%	Explore
T-helper 17 cell	5 studies	51% ± 11%	Explore
mucus secreting cell	5 studies	28% ± 9%	Explore
double negative thymocyte	5 studies	58% ± 16%	Explore
IgA plasma cell	5 studies	28% ± 12%	Explore
granulocyte	5 studies	43% ± 5%	Explore
deuterosomal cell	4 studies	48% ± 7%	Explore
squamous epithelial cell	4 studies	58% ± 18%	Explore
pancreatic A cell	4 studies	78% ± 12%	Explore
type B pancreatic cell	4 studies	65% ± 24%	Explore
glomerular endothelial cell	4 studies	52% ± 11%	Explore
intestinal crypt stem cell	4 studies	34% ± 7%	Explore
glial cell	4 studies	43% ± 25%	Explore
retinal ganglion cell	4 studies	74% ± 22%	Explore
amacrine cell	4 studies	50% ± 22%	Explore
retina horizontal cell	4 studies	47% ± 20%	Explore
retinal pigment epithelial cell	4 studies	46% ± 25%	Explore
retinal rod cell	4 studies	39% ± 19%	Explore
adventitial cell	4 studies	38% ± 14%	Explore
inflammatory macrophage	4 studies	41% ± 18%	Explore
acinar cell	4 studies	59% ± 24%	Explore
muscle cell	4 studies	38% ± 21%	Explore
intermediate monocyte	4 studies	59% ± 20%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	59% ± 5%	Explore
luminal cell of prostate epithelium	4 studies	44% ± 16%	Explore
hepatocyte	4 studies	44% ± 28%	Explore
erythrocyte	4 studies	49% ± 15%	Explore
group 3 innate lymphoid cell	4 studies	66% ± 13%	Explore
keratinocyte	4 studies	51% ± 23%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	39% ± 9%	Explore
duct epithelial cell	3 studies	44% ± 8%	Explore
hillock cell	3 studies	46% ± 17%	Explore
precursor cell	3 studies	72% ± 16%	Explore
pancreatic D cell	3 studies	72% ± 22%	Explore
monocyte-derived dendritic cell	3 studies	49% ± 12%	Explore
podocyte	3 studies	63% ± 10%	Explore
neural crest cell	3 studies	57% ± 20%	Explore
retinal bipolar neuron	3 studies	49% ± 15%	Explore
granule cell	3 studies	22% ± 5%	Explore
OFF-bipolar cell	3 studies	37% ± 17%	Explore
renal principal cell	3 studies	47% ± 11%	Explore
extravillous trophoblast	3 studies	68% ± 7%	Explore
placental villous trophoblast	3 studies	78% ± 8%	Explore
neuroendocrine cell	3 studies	68% ± 27%	Explore
Schwann cell	3 studies	51% ± 23%	Explore
retinal cone cell	3 studies	65% ± 16%	Explore
serous secreting cell	3 studies	47% ± 5%	Explore
adipocyte	3 studies	20% ± 2%	Explore
tissue-resident macrophage	3 studies	43% ± 14%	Explore
intraepithelial lymphocyte	3 studies	46% ± 23%	Explore
Mueller cell	3 studies	40% ± 6%	Explore
ON-bipolar cell	3 studies	37% ± 18%	Explore
rod bipolar cell	3 studies	31% ± 11%	Explore
germinal center B cell	3 studies	56% ± 10%	Explore
myoepithelial cell	3 studies	59% ± 13%	Explore
pancreatic ductal cell	3 studies	89% ± 8%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	77% ± 16%	Explore
T-helper 1 cell	3 studies	56% ± 6%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	45% ± 10%	Explore
double-positive, alpha-beta thymocyte	3 studies	67% ± 12%	Explore
progenitor cell of mammary luminal epithelium	3 studies	43% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	19 studies	49% ± 16%	Explore
peripheral blood	19 studies	48% ± 11%	Explore
brain	18 studies	31% ± 13%	Explore
intestine	11 studies	41% ± 18%	Explore
kidney	9 studies	42% ± 11%	Explore
eye	9 studies	39% ± 18%	Explore
bone marrow	6 studies	39% ± 20%	Explore
pancreas	5 studies	64% ± 25%	Explore
uterus	5 studies	60% ± 9%	Explore
prostate	5 studies	39% ± 16%	Explore
lymph node	5 studies	49% ± 9%	Explore
liver	5 studies	43% ± 16%	Explore
placenta	4 studies	58% ± 23%	Explore
adipose	4 studies	27% ± 12%	Explore
breast	4 studies	53% ± 7%	Explore
heart	3 studies	26% ± 5%	Explore
adrenal gland	3 studies	42% ± 13%	Explore
esophagus	3 studies	53% ± 25%	Explore
skin	3 studies	46% ± 11%	Explore
thymus	3 studies	58% ± 18%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	43049.46	1445 / 1445	100%	425.82	183 / 183
lung	100%	37627.15	578 / 578	100%	409.45	1155 / 1155
breast	100%	32072.30	459 / 459	100%	422.21	1117 / 1118
intestine	100%	42251.31	966 / 966	100%	350.44	526 / 527
bladder	100%	39189.19	21 / 21	100%	344.18	503 / 504
prostate	100%	33683.72	245 / 245	100%	314.92	501 / 502
stomach	100%	28683.61	359 / 359	100%	341.38	285 / 286
brain	100%	25513.74	2632 / 2642	100%	328.10	705 / 705
uterus	100%	38387.95	170 / 170	100%	334.95	457 / 459
ovary	100%	31783.16	180 / 180	100%	277.28	428 / 430
thymus	100%	37627.21	653 / 653	99%	336.26	601 / 605
pancreas	100%	18162.21	327 / 328	99%	298.90	177 / 178
kidney	100%	31271.20	89 / 89	98%	268.34	886 / 901
adrenal gland	100%	33989.71	258 / 258	97%	246.54	224 / 230
skin	100%	44357.75	1809 / 1809	97%	303.14	457 / 472
liver	100%	15204.51	225 / 226	93%	159.28	379 / 406
adipose	100%	37142.17	1204 / 1204	0%	0	0 / 0
blood vessel	100%	44717.11	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	269.92	29 / 29
muscle	100%	34988.18	803 / 803	0%	0	0 / 0
spleen	100%	28746.96	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	383.80	45 / 45
ureter	0%	0	0 / 0	100%	106.12	1 / 1
heart	98%	28261.95	845 / 861	0%	0	0 / 0
peripheral blood	92%	23071.94	856 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	81%	112.84	65 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0045773	Biological process	positive regulation of axon extension
GO_0008219	Biological process	cell death
GO_0030307	Biological process	positive regulation of cell growth
GO_0007507	Biological process	heart development
GO_0006413	Biological process	translational initiation
GO_0006446	Biological process	regulation of translational initiation
GO_0009059	Biological process	macromolecule biosynthetic process
GO_0060999	Biological process	positive regulation of dendritic spine development
GO_0045727	Biological process	positive regulation of translation
GO_0010507	Biological process	negative regulation of autophagy
GO_0051726	Biological process	regulation of cell cycle
GO_0016020	Cellular component	membrane
GO_0016281	Cellular component	eukaryotic translation initiation factor 4F complex
GO_0005829	Cellular component	cytosol
GO_0005912	Cellular component	adherens junction
GO_0030424	Cellular component	axon
GO_0008135	Molecular function	translation factor activity, RNA binding
GO_0003743	Molecular function	translation initiation factor activity
GO_0045296	Molecular function	cadherin binding
GO_0003729	Molecular function	mRNA binding
GO_0003723	Molecular function	RNA binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	EIF4G2
Protein name	Eukaryotic translation initiation factor 4 gamma 2 (eIF-4-gamma 2) (eIF-4G 2) (eIF4G 2) (Death-associated protein 5) (DAP-5) (p97) Eukaryotic translation initiation factor 4 gamma 2
Synonyms	OK/SW-cl.75 hCG_1991788 DAP5 AAG1
Description	FUNCTION: Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases. . FUNCTION: Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases. . FUNCTION: Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases. . FUNCTION: Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases. .
Accessions	H0YD99 ENST00000531647.6 Q2TU89 H0YEW3 ENST00000525681 H0YCH5 ENST00000339995 ENST00000528839.1 ENST00000524932.6 H0Y3P2 ENST00000525681.6 [P78344-1] ENST00000532082.6 D3DQV9 H0YE22 H0YEI7 ENST00000534605.1 H0YDC0 H0YE44 ENST00000339995.11 [P78344-1] H0YD77 ENST00000527526.6 ENST00000530702.2 H0YEN8 ENST00000396525 P78344 E9PKF8 ENST00000396525.7 [P78344-2] H0YEC5 ENST00000532570.6 ENST00000527419.6 H0YCF8 H0YE87 ENST00000530211.6 ENST00000528562.6 ENST00000526148.6 [P78344-1] ENST00000531416.6 ENST00000526148 ENST00000531180.1

EIF4G2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review