EDF1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	43 studies	54% ± 16%	Explore
endothelial cell	41 studies	55% ± 22%	Explore
natural killer cell	39 studies	60% ± 13%	Explore
fibroblast	37 studies	63% ± 19%	Explore
macrophage	36 studies	54% ± 18%	Explore
CD8-positive, alpha-beta T cell	36 studies	58% ± 19%	Explore
T cell	32 studies	57% ± 15%	Explore
pericyte	32 studies	62% ± 20%	Explore
CD4-positive, alpha-beta T cell	32 studies	59% ± 17%	Explore
conventional dendritic cell	28 studies	70% ± 12%	Explore
smooth muscle cell	27 studies	59% ± 21%	Explore
regulatory T cell	27 studies	63% ± 16%	Explore
classical monocyte	26 studies	55% ± 17%	Explore
dendritic cell	25 studies	60% ± 26%	Explore
plasma cell	25 studies	62% ± 22%	Explore
plasmacytoid dendritic cell	24 studies	68% ± 17%	Explore
non-classical monocyte	23 studies	61% ± 16%	Explore
epithelial cell	23 studies	72% ± 19%	Explore
mast cell	22 studies	49% ± 19%	Explore
endothelial cell of lymphatic vessel	21 studies	70% ± 15%	Explore
basal cell	21 studies	67% ± 19%	Explore
mature NK T cell	20 studies	57% ± 15%	Explore
memory B cell	20 studies	55% ± 11%	Explore
naive B cell	20 studies	47% ± 13%	Explore
monocyte	19 studies	58% ± 15%	Explore
gamma-delta T cell	19 studies	57% ± 15%	Explore
connective tissue cell	19 studies	65% ± 22%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	53% ± 16%	Explore
mucosal invariant T cell	16 studies	53% ± 15%	Explore
ciliated cell	16 studies	66% ± 19%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	57% ± 18%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	60% ± 16%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	61% ± 15%	Explore
myofibroblast cell	14 studies	66% ± 21%	Explore
capillary endothelial cell	13 studies	51% ± 18%	Explore
myeloid cell	13 studies	58% ± 20%	Explore
plasmablast	12 studies	72% ± 16%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	55% ± 19%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	57% ± 18%	Explore
secretory cell	12 studies	70% ± 17%	Explore
endothelial cell of artery	12 studies	59% ± 18%	Explore
innate lymphoid cell	11 studies	57% ± 16%	Explore
goblet cell	11 studies	65% ± 27%	Explore
vein endothelial cell	11 studies	64% ± 17%	Explore
endothelial cell of vascular tree	11 studies	66% ± 13%	Explore
type I pneumocyte	10 studies	54% ± 23%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	56% ± 19%	Explore
club cell	10 studies	57% ± 27%	Explore
progenitor cell	10 studies	75% ± 18%	Explore
abnormal cell	10 studies	64% ± 23%	Explore
astrocyte	10 studies	31% ± 18%	Explore
mesothelial cell	10 studies	68% ± 22%	Explore
type II pneumocyte	9 studies	64% ± 26%	Explore
leukocyte	9 studies	56% ± 16%	Explore
T follicular helper cell	9 studies	59% ± 15%	Explore
neuron	8 studies	57% ± 26%	Explore
enterocyte	8 studies	72% ± 27%	Explore
IgG plasma cell	8 studies	48% ± 16%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	69% ± 15%	Explore
epithelial cell of proximal tubule	7 studies	64% ± 18%	Explore
IgA plasma cell	7 studies	55% ± 18%	Explore
microglial cell	7 studies	37% ± 19%	Explore
hematopoietic stem cell	7 studies	58% ± 21%	Explore
brush cell	7 studies	53% ± 19%	Explore
erythrocyte	7 studies	46% ± 24%	Explore
alveolar macrophage	6 studies	47% ± 15%	Explore
hematopoietic precursor cell	6 studies	54% ± 30%	Explore
ionocyte	6 studies	53% ± 13%	Explore
respiratory goblet cell	6 studies	56% ± 21%	Explore
platelet	6 studies	28% ± 9%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	68% ± 20%	Explore
mononuclear phagocyte	6 studies	58% ± 23%	Explore
kidney loop of Henle epithelial cell	6 studies	63% ± 12%	Explore
neutrophil	6 studies	37% ± 12%	Explore
renal alpha-intercalated cell	6 studies	74% ± 10%	Explore
enteroendocrine cell	6 studies	73% ± 28%	Explore
transit amplifying cell	6 studies	59% ± 29%	Explore
glutamatergic neuron	6 studies	34% ± 15%	Explore
precursor B cell	6 studies	54% ± 21%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	67% ± 16%	Explore
CD4-positive helper T cell	5 studies	48% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	53% ± 12%	Explore
exhausted T cell	5 studies	76% ± 10%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	72% ± 16%	Explore
oligodendrocyte	5 studies	33% ± 7%	Explore
erythroblast	5 studies	46% ± 25%	Explore
retinal ganglion cell	5 studies	65% ± 31%	Explore
retinal rod cell	5 studies	41% ± 18%	Explore
pro-B cell	5 studies	48% ± 20%	Explore
T-helper 17 cell	5 studies	70% ± 13%	Explore
group 3 innate lymphoid cell	5 studies	73% ± 10%	Explore
immature B cell	5 studies	65% ± 14%	Explore
mucus secreting cell	5 studies	61% ± 28%	Explore
double negative thymocyte	5 studies	66% ± 14%	Explore
intermediate monocyte	5 studies	67% ± 18%	Explore
hepatocyte	5 studies	53% ± 27%	Explore
granulocyte	5 studies	58% ± 18%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	51% ± 13%	Explore
deuterosomal cell	4 studies	51% ± 12%	Explore
duct epithelial cell	4 studies	73% ± 2%	Explore
squamous epithelial cell	4 studies	49% ± 20%	Explore
glomerular endothelial cell	4 studies	53% ± 16%	Explore
podocyte	4 studies	75% ± 11%	Explore
intestinal crypt stem cell	4 studies	79% ± 14%	Explore
OFF-bipolar cell	4 studies	47% ± 29%	Explore
ON-bipolar cell	4 studies	46% ± 28%	Explore
retinal cone cell	4 studies	58% ± 26%	Explore
lymphocyte	4 studies	77% ± 8%	Explore
amacrine cell	4 studies	59% ± 21%	Explore
retina horizontal cell	4 studies	50% ± 21%	Explore
adventitial cell	4 studies	52% ± 9%	Explore
muscle cell	4 studies	44% ± 22%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	82% ± 7%	Explore
luminal cell of prostate epithelium	4 studies	61% ± 17%	Explore
oligodendrocyte precursor cell	4 studies	51% ± 16%	Explore
interneuron	4 studies	42% ± 23%	Explore
T-helper 1 cell	4 studies	71% ± 11%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	67% ± 22%	Explore
hillock cell	3 studies	47% ± 21%	Explore
precursor cell	3 studies	76% ± 12%	Explore
pancreatic A cell	3 studies	77% ± 16%	Explore
type B pancreatic cell	3 studies	78% ± 13%	Explore
monocyte-derived dendritic cell	3 studies	65% ± 25%	Explore
neural crest cell	3 studies	80% ± 7%	Explore
paneth cell	3 studies	73% ± 17%	Explore
retinal bipolar neuron	3 studies	60% ± 25%	Explore
GABAergic amacrine cell	3 studies	30% ± 13%	Explore
glycinergic amacrine cell	3 studies	32% ± 11%	Explore
renal principal cell	3 studies	63% ± 2%	Explore
thymocyte	3 studies	57% ± 24%	Explore
extravillous trophoblast	3 studies	91% ± 4%	Explore
placental villous trophoblast	3 studies	93% ± 2%	Explore
megakaryocyte	3 studies	43% ± 6%	Explore
neuroendocrine cell	3 studies	70% ± 20%	Explore
retinal pigment epithelial cell	3 studies	43% ± 34%	Explore
serous secreting cell	3 studies	69% ± 8%	Explore
intraepithelial lymphocyte	3 studies	61% ± 8%	Explore
Mueller cell	3 studies	53% ± 11%	Explore
rod bipolar cell	3 studies	47% ± 20%	Explore
acinar cell	3 studies	63% ± 23%	Explore
endothelial cell of sinusoid	3 studies	35% ± 12%	Explore
germinal center B cell	3 studies	60% ± 1%	Explore
adipocyte	3 studies	20% ± 6%	Explore
myoepithelial cell	3 studies	73% ± 7%	Explore
inflammatory macrophage	3 studies	47% ± 10%	Explore
IgM plasma cell	3 studies	56% ± 13%	Explore
GABAergic neuron	3 studies	35% ± 6%	Explore
glial cell	3 studies	61% ± 24%	Explore
keratinocyte	3 studies	72% ± 7%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	61% ± 6%	Explore
progenitor cell of mammary luminal epithelium	3 studies	86% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	20 studies	57% ± 15%	Explore
lung	18 studies	62% ± 17%	Explore
intestine	13 studies	59% ± 24%	Explore
brain	11 studies	34% ± 11%	Explore
kidney	9 studies	61% ± 17%	Explore
eye	9 studies	42% ± 18%	Explore
bone marrow	7 studies	37% ± 18%	Explore
liver	7 studies	50% ± 22%	Explore
lymph node	6 studies	63% ± 16%	Explore
uterus	5 studies	65% ± 24%	Explore
prostate	5 studies	49% ± 23%	Explore
pancreas	4 studies	66% ± 25%	Explore
placenta	4 studies	68% ± 27%	Explore
breast	4 studies	71% ± 8%	Explore
heart	3 studies	30% ± 13%	Explore
adrenal gland	3 studies	53% ± 14%	Explore
esophagus	3 studies	65% ± 29%	Explore
skin	3 studies	50% ± 23%	Explore
thymus	3 studies	66% ± 26%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	9951.74	258 / 258	100%	738.83	230 / 230
esophagus	100%	8128.04	1445 / 1445	100%	310.56	183 / 183
liver	100%	9062.64	226 / 226	100%	684.21	406 / 406
ovary	100%	9297.42	180 / 180	100%	413.97	430 / 430
skin	100%	9114.72	1809 / 1809	100%	548.08	472 / 472
thymus	100%	10901.09	653 / 653	100%	915.15	605 / 605
brain	100%	8193.05	2640 / 2642	100%	559.58	705 / 705
uterus	100%	7805.21	170 / 170	100%	754.89	458 / 459
intestine	100%	8593.10	966 / 966	100%	568.89	525 / 527
prostate	100%	11561.00	245 / 245	100%	1076.36	500 / 502
pancreas	100%	9549.43	328 / 328	99%	632.47	177 / 178
kidney	100%	9620.80	89 / 89	99%	537.79	895 / 901
stomach	100%	7555.21	359 / 359	99%	444.83	284 / 286
lung	100%	7256.30	578 / 578	99%	469.90	1144 / 1155
bladder	100%	7337.62	21 / 21	99%	613.47	498 / 504
breast	100%	8127.57	459 / 459	98%	578.31	1099 / 1118
adipose	100%	7497.10	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	937.59	80 / 80
lymph node	0%	0	0 / 0	100%	1181.41	29 / 29
spleen	100%	8019.95	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	729.61	45 / 45
ureter	0%	0	0 / 0	100%	800.35	1 / 1
blood vessel	100%	7907.74	1334 / 1335	0%	0	0 / 0
muscle	100%	6968.94	802 / 803	0%	0	0 / 0
heart	100%	7257.63	858 / 861	0%	0	0 / 0
peripheral blood	98%	5826.73	911 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0019216	Biological process	regulation of lipid metabolic process
GO_0043388	Biological process	positive regulation of DNA binding
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0045446	Biological process	endothelial cell differentiation
GO_0006355	Biological process	regulation of DNA-templated transcription
GO_0005730	Cellular component	nucleolus
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0001094	Molecular function	TFIID-class transcription factor complex binding
GO_0003677	Molecular function	DNA binding
GO_0003713	Molecular function	transcription coactivator activity
GO_0005516	Molecular function	calmodulin binding
GO_0005515	Molecular function	protein binding
GO_0003723	Molecular function	RNA binding

Gene name	EDF1
Protein name	Endothelial differentiation-related factor 1 (EDF-1) (Multiprotein-bridging factor 1) (MBF1)
Synonyms
Description	FUNCTION: Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism. .
Accessions	ENST00000224073.6 [O60869-1] ENST00000371649.5 [O60869-3] O60869 ENST00000371648.4 [O60869-2]

EDF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review