ZFP36L2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045577Biological processregulation of B cell differentiation
GO_0071560Biological processcellular response to transforming growth factor beta stimulus
GO_0030097Biological processhemopoiesis
GO_0043488Biological processregulation of mRNA stability
GO_0006402Biological processmRNA catabolic process
GO_0048103Biological processsomatic stem cell division
GO_0071364Biological processcellular response to epidermal growth factor stimulus
GO_0045599Biological processnegative regulation of fat cell differentiation
GO_0061158Biological process3'-UTR-mediated mRNA destabilization
GO_0097011Biological processcellular response to granulocyte macrophage colony-stimulating factor stimulus
GO_0033077Biological processT cell differentiation in thymus
GO_0071356Biological processcellular response to tumor necrosis factor
GO_0060216Biological processdefinitive hemopoiesis
GO_1900153Biological processpositive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO_0070371Biological processERK1 and ERK2 cascade
GO_2000737Biological processnegative regulation of stem cell differentiation
GO_1901991Biological processnegative regulation of mitotic cell cycle phase transition
GO_0000288Biological processnuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO_0071385Biological processcellular response to glucocorticoid stimulus
GO_0009611Biological processresponse to wounding
GO_0044344Biological processcellular response to fibroblast growth factor stimulus
GO_0035019Biological processsomatic stem cell population maintenance
GO_0005737Cellular componentcytoplasm
GO_1990904Cellular componentribonucleoprotein complex
GO_0005634Cellular componentnucleus
GO_0035925Molecular functionmRNA 3'-UTR AU-rich region binding
GO_0046872Molecular functionmetal ion binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameZFP36L2
Protein namemRNA decay activator protein ZFP36L2 (Butyrate response factor 2) (EGF-response factor 2) (ERF-2) (TPA-induced sequence 11d) (Zinc finger protein 36, C3H1 type-like 2) (ZFP36-like 2)
SynonymsERF2
TIS11D
RNF162C
DescriptionFUNCTION: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis . Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery . Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes . Binds to 3'-UTR ARE of numerous mRNAs . Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner . Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA. Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA. Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation. Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA. .

AccessionsENST00000282388.4
P47974