VAPA | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	48 studies	45% ± 17%	Explore
macrophage	41 studies	43% ± 15%	Explore
fibroblast	41 studies	44% ± 13%	Explore
natural killer cell	36 studies	33% ± 11%	Explore
B cell	35 studies	32% ± 10%	Explore
pericyte	34 studies	44% ± 15%	Explore
CD4-positive, alpha-beta T cell	31 studies	35% ± 12%	Explore
smooth muscle cell	30 studies	43% ± 13%	Explore
CD8-positive, alpha-beta T cell	30 studies	33% ± 11%	Explore
T cell	28 studies	32% ± 11%	Explore
conventional dendritic cell	27 studies	40% ± 15%	Explore
classical monocyte	26 studies	47% ± 15%	Explore
epithelial cell	24 studies	48% ± 19%	Explore
non-classical monocyte	23 studies	46% ± 14%	Explore
basal cell	23 studies	48% ± 19%	Explore
mast cell	22 studies	46% ± 18%	Explore
endothelial cell of lymphatic vessel	22 studies	44% ± 14%	Explore
regulatory T cell	22 studies	37% ± 8%	Explore
dendritic cell	21 studies	41% ± 20%	Explore
monocyte	21 studies	41% ± 12%	Explore
ciliated cell	20 studies	63% ± 19%	Explore
memory B cell	19 studies	29% ± 7%	Explore
plasmacytoid dendritic cell	19 studies	34% ± 12%	Explore
naive B cell	18 studies	28% ± 8%	Explore
connective tissue cell	18 studies	45% ± 14%	Explore
astrocyte	18 studies	32% ± 13%	Explore
mature NK T cell	18 studies	30% ± 7%	Explore
gamma-delta T cell	17 studies	35% ± 15%	Explore
myeloid cell	16 studies	40% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	34% ± 11%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	15 studies	30% ± 10%	Explore
myofibroblast cell	15 studies	46% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	34% ± 11%	Explore
capillary endothelial cell	14 studies	39% ± 13%	Explore
microglial cell	14 studies	32% ± 11%	Explore
plasma cell	13 studies	33% ± 11%	Explore
oligodendrocyte	13 studies	38% ± 13%	Explore
endothelial cell of artery	13 studies	45% ± 14%	Explore
vein endothelial cell	13 studies	46% ± 13%	Explore
mucosal invariant T cell	13 studies	30% ± 9%	Explore
endothelial cell of vascular tree	13 studies	52% ± 16%	Explore
type I pneumocyte	12 studies	49% ± 15%	Explore
type II pneumocyte	12 studies	55% ± 20%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	34% ± 10%	Explore
mesothelial cell	12 studies	50% ± 16%	Explore
oligodendrocyte precursor cell	12 studies	41% ± 18%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	33% ± 12%	Explore
club cell	11 studies	43% ± 14%	Explore
secretory cell	11 studies	49% ± 10%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	35% ± 10%	Explore
glutamatergic neuron	11 studies	42% ± 22%	Explore
progenitor cell	11 studies	37% ± 15%	Explore
plasmablast	10 studies	37% ± 23%	Explore
neutrophil	10 studies	32% ± 7%	Explore
leukocyte	10 studies	37% ± 9%	Explore
GABAergic neuron	10 studies	39% ± 18%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	34% ± 14%	Explore
platelet	9 studies	31% ± 7%	Explore
abnormal cell	9 studies	45% ± 14%	Explore
neuron	9 studies	52% ± 16%	Explore
goblet cell	9 studies	35% ± 18%	Explore
adipocyte	9 studies	26% ± 6%	Explore
alveolar macrophage	8 studies	53% ± 17%	Explore
respiratory goblet cell	8 studies	40% ± 18%	Explore
renal alpha-intercalated cell	8 studies	55% ± 19%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	34% ± 7%	Explore
mononuclear phagocyte	7 studies	48% ± 15%	Explore
kidney loop of Henle epithelial cell	7 studies	38% ± 13%	Explore
kidney distal convoluted tubule epithelial cell	7 studies	43% ± 16%	Explore
enterocyte	7 studies	34% ± 12%	Explore
hematopoietic stem cell	7 studies	42% ± 10%	Explore
innate lymphoid cell	7 studies	37% ± 11%	Explore
T follicular helper cell	7 studies	35% ± 5%	Explore
ionocyte	6 studies	55% ± 9%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	39% ± 9%	Explore
epithelial cell of proximal tubule	6 studies	34% ± 9%	Explore
amacrine cell	6 studies	42% ± 17%	Explore
retinal ganglion cell	6 studies	68% ± 28%	Explore
precursor B cell	6 studies	39% ± 12%	Explore
mucus secreting cell	6 studies	26% ± 6%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	37% ± 14%	Explore
erythrocyte	6 studies	31% ± 18%	Explore
hematopoietic precursor cell	5 studies	53% ± 18%	Explore
enteroendocrine cell	5 studies	43% ± 19%	Explore
transit amplifying cell	5 studies	32% ± 20%	Explore
glial cell	5 studies	36% ± 18%	Explore
erythroblast	5 studies	41% ± 21%	Explore
lymphocyte	5 studies	42% ± 15%	Explore
pro-B cell	5 studies	32% ± 8%	Explore
brush cell	5 studies	34% ± 15%	Explore
immature B cell	5 studies	39% ± 13%	Explore
retina horizontal cell	5 studies	49% ± 15%	Explore
adventitial cell	5 studies	36% ± 12%	Explore
cardiac muscle cell	5 studies	29% ± 2%	Explore
intermediate monocyte	5 studies	58% ± 17%	Explore
hepatocyte	5 studies	42% ± 28%	Explore
granulocyte	5 studies	50% ± 13%	Explore
interneuron	5 studies	49% ± 20%	Explore
deuterosomal cell	4 studies	31% ± 7%	Explore
duct epithelial cell	4 studies	31% ± 7%	Explore
squamous epithelial cell	4 studies	42% ± 24%	Explore
pancreatic A cell	4 studies	71% ± 6%	Explore
type B pancreatic cell	4 studies	65% ± 15%	Explore
exhausted T cell	4 studies	44% ± 10%	Explore
intestinal crypt stem cell	4 studies	27% ± 8%	Explore
IgG plasma cell	4 studies	17% ± 1%	Explore
OFF-bipolar cell	4 studies	44% ± 29%	Explore
ON-bipolar cell	4 studies	45% ± 30%	Explore
megakaryocyte	4 studies	45% ± 14%	Explore
retinal cone cell	4 studies	34% ± 14%	Explore
retinal rod cell	4 studies	25% ± 7%	Explore
Mueller cell	4 studies	37% ± 6%	Explore
CD4-positive helper T cell	4 studies	30% ± 12%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	70% ± 4%	Explore
myoepithelial cell	4 studies	48% ± 11%	Explore
luminal cell of prostate epithelium	4 studies	37% ± 11%	Explore
group 3 innate lymphoid cell	4 studies	51% ± 11%	Explore
keratinocyte	4 studies	49% ± 19%	Explore
T-helper 17 cell	4 studies	38% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	28% ± 7%	Explore
hillock cell	3 studies	29% ± 11%	Explore
pancreatic D cell	3 studies	61% ± 16%	Explore
monocyte-derived dendritic cell	3 studies	43% ± 15%	Explore
glomerular endothelial cell	3 studies	38% ± 7%	Explore
podocyte	3 studies	63% ± 12%	Explore
neural crest cell	3 studies	41% ± 3%	Explore
retinal bipolar neuron	3 studies	41% ± 13%	Explore
GABAergic interneuron	3 studies	26% ± 3%	Explore
GABAergic amacrine cell	3 studies	31% ± 11%	Explore
glycinergic amacrine cell	3 studies	33% ± 9%	Explore
renal principal cell	3 studies	46% ± 10%	Explore
extravillous trophoblast	3 studies	58% ± 11%	Explore
placental villous trophoblast	3 studies	60% ± 7%	Explore
neuroendocrine cell	3 studies	47% ± 13%	Explore
retinal pigment epithelial cell	3 studies	53% ± 17%	Explore
serous secreting cell	3 studies	38% ± 6%	Explore
tissue-resident macrophage	3 studies	46% ± 6%	Explore
intraepithelial lymphocyte	3 studies	38% ± 18%	Explore
rod bipolar cell	3 studies	35% ± 7%	Explore
germinal center B cell	3 studies	31% ± 2%	Explore
IgA plasma cell	3 studies	19% ± 4%	Explore
endothelial cell of sinusoid	3 studies	31% ± 8%	Explore
muscle cell	3 studies	53% ± 15%	Explore
acinar cell	3 studies	54% ± 24%	Explore
pancreatic ductal cell	3 studies	76% ± 12%	Explore
ependymal cell	3 studies	34% ± 15%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	60% ± 28%	Explore
melanocyte	3 studies	52% ± 16%	Explore
granule cell	3 studies	27% ± 7%	Explore
T-helper 1 cell	3 studies	41% ± 3%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	31% ± 10%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	27% ± 10%	Explore
double negative thymocyte	3 studies	55% ± 20%	Explore
progenitor cell of mammary luminal epithelium	3 studies	53% ± 9%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	20 studies	45% ± 13%	Explore
brain	18 studies	38% ± 17%	Explore
peripheral blood	17 studies	39% ± 12%	Explore
intestine	11 studies	34% ± 15%	Explore
kidney	9 studies	36% ± 10%	Explore
eye	9 studies	37% ± 15%	Explore
liver	6 studies	38% ± 20%	Explore
heart	5 studies	26% ± 5%	Explore
uterus	5 studies	49% ± 18%	Explore
adipose	5 studies	26% ± 7%	Explore
prostate	5 studies	37% ± 15%	Explore
lymph node	5 studies	41% ± 12%	Explore
pancreas	4 studies	66% ± 13%	Explore
placenta	4 studies	49% ± 20%	Explore
bone marrow	4 studies	30% ± 11%	Explore
esophagus	4 studies	39% ± 27%	Explore
skin	4 studies	34% ± 18%	Explore
breast	4 studies	50% ± 9%	Explore
adrenal gland	3 studies	27% ± 4%	Explore
thymus	3 studies	52% ± 26%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	7798.28	459 / 459	100%	53.22	1118 / 1118
esophagus	100%	9168.83	1445 / 1445	100%	45.50	183 / 183
lung	100%	9842.71	578 / 578	100%	51.42	1155 / 1155
ovary	100%	10719.94	180 / 180	100%	36.19	430 / 430
uterus	100%	7481.46	170 / 170	100%	50.80	459 / 459
brain	100%	8481.24	2641 / 2642	100%	58.71	705 / 705
prostate	100%	6962.70	245 / 245	100%	41.54	501 / 502
kidney	100%	6693.62	89 / 89	100%	34.57	899 / 901
liver	100%	3872.27	226 / 226	100%	26.73	405 / 406
pancreas	100%	4995.40	327 / 328	100%	41.29	178 / 178
thymus	100%	6992.74	653 / 653	100%	50.48	603 / 605
bladder	100%	8570.86	21 / 21	100%	42.84	502 / 504
intestine	100%	9124.01	966 / 966	99%	33.26	524 / 527
skin	100%	8324.96	1809 / 1809	99%	33.69	469 / 472
stomach	100%	7290.26	359 / 359	99%	33.67	284 / 286
adrenal gland	100%	15968.51	258 / 258	99%	41.60	228 / 230
adipose	100%	7944.15	1204 / 1204	0%	0	0 / 0
blood vessel	100%	9804.02	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	31.18	29 / 29
muscle	100%	8447.49	803 / 803	0%	0	0 / 0
spleen	100%	6682.86	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	44.90	45 / 45
ureter	0%	0	0 / 0	100%	15.80	1 / 1
peripheral blood	99%	9036.23	917 / 929	0%	0	0 / 0
heart	97%	6208.82	833 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	95%	21.81	76 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006686	Biological process	sphingomyelin biosynthetic process
GO_0015914	Biological process	phospholipid transport
GO_0015918	Biological process	sterol transport
GO_0090114	Biological process	COPII-coated vesicle budding
GO_0031175	Biological process	neuron projection development
GO_0044829	Biological process	positive regulation by host of viral genome replication
GO_0007029	Biological process	endoplasmic reticulum organization
GO_0061025	Biological process	membrane fusion
GO_0061817	Biological process	endoplasmic reticulum-plasma membrane tethering
GO_0035627	Biological process	ceramide transport
GO_0044828	Biological process	negative regulation by host of viral genome replication
GO_0070972	Biological process	protein localization to endoplasmic reticulum
GO_0043123	Biological process	positive regulation of canonical NF-kappaB signal transduction
GO_0034975	Biological process	protein folding in endoplasmic reticulum
GO_0019076	Biological process	viral release from host cell
GO_0006888	Biological process	endoplasmic reticulum to Golgi vesicle-mediated transport
GO_0030301	Biological process	cholesterol transport
GO_0005886	Cellular component	plasma membrane
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0035577	Cellular component	azurophil granule membrane
GO_0070971	Cellular component	endoplasmic reticulum exit site
GO_0000139	Cellular component	Golgi membrane
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005829	Cellular component	cytosol
GO_0015630	Cellular component	microtubule cytoskeleton
GO_0005923	Cellular component	bicellular tight junction
GO_0031965	Cellular component	nuclear membrane
GO_0031982	Cellular component	vesicle
GO_0042803	Molecular function	protein homodimerization activity
GO_0019904	Molecular function	protein domain specific binding
GO_0045296	Molecular function	cadherin binding
GO_0033149	Molecular function	FFAT motif binding
GO_0008017	Molecular function	microtubule binding
GO_0046982	Molecular function	protein heterodimerization activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	VAPA
Protein name	VAMP associated protein A Vesicle-associated membrane protein-associated protein A (VAMP-A) (VAMP-associated protein A) (VAP-A) (33 kDa VAMP-associated protein) (VAP-33)
Synonyms	VAP33
Description	FUNCTION: Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44 . STARD3-VAPA interaction enables cholesterol transfer from the ER to endosomes . Via interaction with WDR44 participates in neosynthesized protein export . In addition, recruited to the plasma membrane through OSBPL3 binding . The OSBPL3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface . With OSBPL3, may regulate ER morphology . May play a role in vesicle trafficking . .
Accessions	ENST00000400000.7 [Q9P0L0-1] ENST00000585042.5 J3QKM9 ENST00000340541.4 [Q9P0L0-2] Q9P0L0

VAPA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review