TOP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0012501Biological processprogrammed cell death
GO_0007059Biological processchromosome segregation
GO_0006260Biological processDNA replication
GO_0006338Biological processchromatin remodeling
GO_0032922Biological processcircadian regulation of gene expression
GO_0007623Biological processcircadian rhythm
GO_0006265Biological processDNA topological change
GO_0040016Biological processembryonic cleavage
GO_0016310Biological processphosphorylation
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0005730Cellular componentnucleolus
GO_0032993Cellular componentprotein-DNA complex
GO_0000228Cellular componentnuclear chromosome
GO_0043204Cellular componentperikaryon
GO_0005654Cellular componentnucleoplasm
GO_0001650Cellular componentfibrillar center
GO_0000932Cellular componentP-body
GO_0001673Cellular componentmale germ cell nucleus
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0008301Molecular functionDNA binding, bending
GO_0019904Molecular functionprotein domain specific binding
GO_0003682Molecular functionchromatin binding
GO_0003697Molecular functionsingle-stranded DNA binding
GO_0003690Molecular functiondouble-stranded DNA binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0097100Molecular functionsupercoiled DNA binding
GO_0003917Molecular functionDNA topoisomerase type I (single strand cut, ATP-independent) activity
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTOP1
Protein nameDNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)
TOP1 protein
DNA topoisomerase I (EC 5.6.2.1) (DNA topoisomerase 1)
DNA topoisomerase I
Synonyms
DescriptionFUNCTION: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Involved in the circadian transcription of the core circadian clock component BMAL1 by altering the chromatin structure around the ROR response elements (ROREs) on the BMAL1 promoter. .

FUNCTION: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. .

FUNCTION: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. .

AccessionsENST00000361337.3
ENST00000680945.1
B9EG90
P11387
ENST00000681113.1
A0A7P0T9R7
Q6NWZ5
Q6PK95
A0A7P0T852