TMSB4X | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	51 studies	90% ± 17%	Explore
macrophage	51 studies	87% ± 21%	Explore
natural killer cell	49 studies	95% ± 11%	Explore
endothelial cell	49 studies	81% ± 24%	Explore
fibroblast	45 studies	82% ± 26%	Explore
T cell	44 studies	88% ± 21%	Explore
pericyte	41 studies	81% ± 27%	Explore
CD8-positive, alpha-beta T cell	41 studies	93% ± 16%	Explore
CD4-positive, alpha-beta T cell	37 studies	92% ± 16%	Explore
conventional dendritic cell	34 studies	96% ± 12%	Explore
smooth muscle cell	33 studies	79% ± 28%	Explore
plasmacytoid dendritic cell	33 studies	94% ± 14%	Explore
dendritic cell	32 studies	89% ± 20%	Explore
endothelial cell of lymphatic vessel	30 studies	84% ± 26%	Explore
classical monocyte	29 studies	94% ± 14%	Explore
monocyte	28 studies	89% ± 20%	Explore
non-classical monocyte	28 studies	95% ± 15%	Explore
regulatory T cell	28 studies	97% ± 7%	Explore
mast cell	27 studies	81% ± 27%	Explore
plasma cell	27 studies	76% ± 24%	Explore
epithelial cell	27 studies	81% ± 22%	Explore
mature NK T cell	25 studies	95% ± 12%	Explore
gamma-delta T cell	22 studies	97% ± 5%	Explore
memory B cell	21 studies	98% ± 3%	Explore
basal cell	21 studies	75% ± 24%	Explore
microglial cell	20 studies	68% ± 25%	Explore
naive B cell	19 studies	97% ± 6%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	19 studies	92% ± 19%	Explore
connective tissue cell	19 studies	92% ± 15%	Explore
mucosal invariant T cell	18 studies	93% ± 18%	Explore
neutrophil	18 studies	87% ± 15%	Explore
ciliated cell	17 studies	65% ± 28%	Explore
CD16-negative, CD56-bright natural killer cell, human	17 studies	85% ± 26%	Explore
capillary endothelial cell	17 studies	92% ± 12%	Explore
myeloid cell	17 studies	79% ± 28%	Explore
CD16-positive, CD56-dim natural killer cell, human	16 studies	93% ± 19%	Explore
endothelial cell of artery	16 studies	94% ± 6%	Explore
myofibroblast cell	16 studies	88% ± 22%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	15 studies	98% ± 6%	Explore
vein endothelial cell	15 studies	91% ± 14%	Explore
endothelial cell of vascular tree	15 studies	86% ± 23%	Explore
astrocyte	14 studies	43% ± 19%	Explore
mesothelial cell	14 studies	82% ± 24%	Explore
effector memory CD8-positive, alpha-beta T cell	13 studies	85% ± 24%	Explore
innate lymphoid cell	13 studies	98% ± 4%	Explore
CD4-positive, alpha-beta memory T cell	13 studies	96% ± 6%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	96% ± 8%	Explore
goblet cell	13 studies	81% ± 27%	Explore
plasmablast	12 studies	93% ± 6%	Explore
secretory cell	12 studies	89% ± 14%	Explore
leukocyte	12 studies	95% ± 7%	Explore
erythrocyte	12 studies	65% ± 24%	Explore
oligodendrocyte	12 studies	41% ± 12%	Explore
progenitor cell	12 studies	82% ± 29%	Explore
platelet	11 studies	94% ± 10%	Explore
glutamatergic neuron	11 studies	55% ± 19%	Explore
type I pneumocyte	10 studies	84% ± 23%	Explore
T follicular helper cell	10 studies	100% ± 1%	Explore
club cell	10 studies	73% ± 28%	Explore
GABAergic neuron	10 studies	50% ± 18%	Explore
neuron	10 studies	69% ± 21%	Explore
IgG plasma cell	10 studies	74% ± 23%	Explore
type II pneumocyte	9 studies	85% ± 24%	Explore
IgA plasma cell	9 studies	71% ± 24%	Explore
alveolar macrophage	8 studies	83% ± 21%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	99% ± 3%	Explore
mononuclear phagocyte	8 studies	86% ± 23%	Explore
abnormal cell	8 studies	88% ± 12%	Explore
enterocyte	8 studies	85% ± 25%	Explore
hematopoietic stem cell	8 studies	98% ± 1%	Explore
respiratory goblet cell	7 studies	81% ± 18%	Explore
effector CD4-positive, alpha-beta T cell	7 studies	99% ± 2%	Explore
interneuron	7 studies	65% ± 14%	Explore
oligodendrocyte precursor cell	7 studies	35% ± 24%	Explore
enteroendocrine cell	7 studies	81% ± 23%	Explore
brush cell	7 studies	75% ± 22%	Explore
CD4-positive helper T cell	6 studies	98% ± 2%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	6 studies	85% ± 28%	Explore
hematopoietic precursor cell	6 studies	73% ± 30%	Explore
ionocyte	6 studies	90% ± 13%	Explore
kidney loop of Henle epithelial cell	6 studies	37% ± 13%	Explore
renal alpha-intercalated cell	6 studies	98% ± 2%	Explore
megakaryocyte	6 studies	92% ± 15%	Explore
transit amplifying cell	6 studies	89% ± 16%	Explore
retinal ganglion cell	6 studies	65% ± 33%	Explore
lymphocyte	6 studies	79% ± 30%	Explore
precursor B cell	6 studies	98% ± 3%	Explore
glial cell	6 studies	77% ± 27%	Explore
immature B cell	6 studies	99% ± 1%	Explore
intermediate monocyte	6 studies	95% ± 7%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	98% ± 2%	Explore
granulocyte	6 studies	96% ± 5%	Explore
CD4-positive, alpha-beta cytotoxic T cell	5 studies	92% ± 13%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	98% ± 3%	Explore
exhausted T cell	5 studies	99% ± 1%	Explore
endothelial cell of sinusoid	5 studies	41% ± 30%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	69% ± 26%	Explore
epithelial cell of proximal tubule	5 studies	53% ± 25%	Explore
erythroblast	5 studies	59% ± 26%	Explore
OFF-bipolar cell	5 studies	42% ± 31%	Explore
ON-bipolar cell	5 studies	64% ± 26%	Explore
T-helper 17 cell	5 studies	100% ± 0%	Explore
group 3 innate lymphoid cell	5 studies	99% ± 2%	Explore
inflammatory macrophage	5 studies	89% ± 12%	Explore
double negative thymocyte	5 studies	99% ± 1%	Explore
adipocyte	5 studies	30% ± 7%	Explore
deuterosomal cell	4 studies	62% ± 19%	Explore
duct epithelial cell	4 studies	88% ± 7%	Explore
precursor cell	4 studies	75% ± 32%	Explore
squamous epithelial cell	4 studies	54% ± 28%	Explore
pancreatic A cell	4 studies	68% ± 22%	Explore
type B pancreatic cell	4 studies	56% ± 29%	Explore
monocyte-derived dendritic cell	4 studies	100% ± 0%	Explore
cholangiocyte	4 studies	42% ± 32%	Explore
glomerular endothelial cell	4 studies	94% ± 5%	Explore
kidney connecting tubule epithelial cell	4 studies	95% ± 4%	Explore
podocyte	4 studies	99% ± 1%	Explore
intestinal crypt stem cell	4 studies	96% ± 3%	Explore
retinal bipolar neuron	4 studies	68% ± 26%	Explore
pro-B cell	4 studies	99% ± 1%	Explore
neuroendocrine cell	4 studies	94% ± 5%	Explore
Schwann cell	4 studies	75% ± 31%	Explore
amacrine cell	4 studies	60% ± 21%	Explore
retina horizontal cell	4 studies	46% ± 24%	Explore
adventitial cell	4 studies	90% ± 13%	Explore
mucus secreting cell	4 studies	55% ± 30%	Explore
Mueller cell	4 studies	27% ± 8%	Explore
muscle cell	4 studies	44% ± 29%	Explore
germinal center B cell	4 studies	100% ± 0%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	93% ± 6%	Explore
hepatocyte	4 studies	41% ± 20%	Explore
IgM plasma cell	4 studies	85% ± 14%	Explore
keratinocyte	4 studies	93% ± 7%	Explore
melanocyte	4 studies	55% ± 30%	Explore
T-helper 1 cell	4 studies	100% ± 0%	Explore
Langerhans cell	3 studies	100% ± 0%	Explore
hillock cell	3 studies	64% ± 30%	Explore
pancreatic D cell	3 studies	78% ± 15%	Explore
hepatic stellate cell	3 studies	30% ± 14%	Explore
renal beta-intercalated cell	3 studies	98% ± 2%	Explore
neural crest cell	3 studies	94% ± 6%	Explore
paneth cell	3 studies	80% ± 22%	Explore
GABAergic amacrine cell	3 studies	45% ± 14%	Explore
glycinergic amacrine cell	3 studies	41% ± 10%	Explore
retinal rod cell	3 studies	34% ± 13%	Explore
renal principal cell	3 studies	96% ± 1%	Explore
thymocyte	3 studies	100% ± 0%	Explore
serous secreting cell	3 studies	61% ± 0%	Explore
endocardial cell	3 studies	58% ± 21%	Explore
tissue-resident macrophage	3 studies	84% ± 21%	Explore
follicular B cell	3 studies	100% ± 0%	Explore
intraepithelial lymphocyte	3 studies	100% ± 0%	Explore
rod bipolar cell	3 studies	74% ± 21%	Explore
chondrocyte	3 studies	28% ± 11%	Explore
myoepithelial cell	3 studies	93% ± 6%	Explore
luminal cell of prostate epithelium	3 studies	84% ± 7%	Explore
acinar cell	3 studies	82% ± 17%	Explore
pancreatic ductal cell	3 studies	97% ± 2%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	100% ± 0%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	99% ± 1%	Explore
double-positive, alpha-beta thymocyte	3 studies	99% ± 0%	Explore
progenitor cell of mammary luminal epithelium	3 studies	76% ± 14%	Explore
mural cell	3 studies	70% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	22 studies	94% ± 10%	Explore
lung	19 studies	84% ± 18%	Explore
brain	16 studies	57% ± 15%	Explore
intestine	13 studies	88% ± 18%	Explore
eye	10 studies	44% ± 22%	Explore
kidney	9 studies	71% ± 24%	Explore
liver	7 studies	53% ± 24%	Explore
bone marrow	6 studies	75% ± 34%	Explore
heart	6 studies	39% ± 17%	Explore
pancreas	5 studies	67% ± 22%	Explore
lymph node	5 studies	98% ± 2%	Explore
uterus	5 studies	94% ± 9%	Explore
prostate	5 studies	65% ± 35%	Explore
adipose	4 studies	59% ± 28%	Explore
esophagus	4 studies	68% ± 23%	Explore
placenta	4 studies	48% ± 23%	Explore
skin	4 studies	82% ± 23%	Explore
breast	4 studies	92% ± 5%	Explore
stomach	3 studies	65% ± 22%	Explore
thymus	3 studies	72% ± 38%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	128603.58	578 / 578	100%	2900.06	1155 / 1155
uterus	100%	74028.63	170 / 170	100%	3061.99	459 / 459
bladder	100%	56990.29	21 / 21	99%	3177.39	500 / 504
stomach	100%	64026.03	359 / 359	99%	2561.20	283 / 286
ovary	100%	51090.47	180 / 180	99%	2125.80	425 / 430
breast	100%	91368.36	459 / 459	99%	2234.42	1103 / 1118
intestine	99%	60842.84	952 / 966	100%	2982.61	526 / 527
prostate	99%	50346.36	243 / 245	98%	1127.16	490 / 502
kidney	99%	54302.02	88 / 89	98%	1995.89	880 / 901
brain	96%	53195.78	2542 / 2642	99%	2600.99	701 / 705
esophagus	99%	54859.47	1427 / 1445	96%	1478.98	176 / 183
adrenal gland	100%	70998.09	258 / 258	94%	1388.93	216 / 230
thymus	97%	35934.33	633 / 653	96%	2475.75	583 / 605
pancreas	74%	18814.44	244 / 328	98%	3299.29	174 / 178
skin	99%	63321.69	1783 / 1809	72%	1060.24	342 / 472
liver	45%	9879.02	101 / 226	75%	1017.16	305 / 406
adipose	100%	124269.51	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	7605.29	29 / 29
spleen	100%	156041.24	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	2025.50	45 / 45
ureter	0%	0	0 / 0	100%	3234.58	1 / 1
blood vessel	100%	93759.61	1331 / 1335	0%	0	0 / 0
peripheral blood	100%	201856.50	926 / 929	0%	0	0 / 0
heart	90%	30527.80	777 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	21%	187.16	17 / 80
muscle	14%	2919.05	110 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_1905273	Biological process	positive regulation of proton-transporting ATP synthase activity, rotational mechanism
GO_0043536	Biological process	positive regulation of blood vessel endothelial cell migration
GO_0042989	Biological process	sequestering of actin monomers
GO_0050728	Biological process	negative regulation of inflammatory response
GO_0030334	Biological process	regulation of cell migration
GO_2001028	Biological process	positive regulation of endothelial cell chemotaxis
GO_2001171	Biological process	positive regulation of ATP biosynthetic process
GO_0007015	Biological process	actin filament organization
GO_0033209	Biological process	tumor necrosis factor-mediated signaling pathway
GO_0043124	Biological process	negative regulation of canonical NF-kappaB signal transduction
GO_0005856	Cellular component	cytoskeleton
GO_0005576	Cellular component	extracellular region
GO_0005829	Cellular component	cytosol
GO_0031093	Cellular component	platelet alpha granule lumen
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0019899	Molecular function	enzyme binding
GO_0003785	Molecular function	actin monomer binding
GO_0003723	Molecular function	RNA binding
GO_0140311	Molecular function	protein sequestering activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	TMSB4X
Protein name	TMSB4X protein Thymosin beta-4 Thymosin beta Thymosin beta-4 (T beta-4) (Fx) [Cleaved into: Hemoregulatory peptide AcSDKP (Ac-Ser-Asp-Lys-Pro) (N-acetyl-SDKP) (AcSDKP) (Seraspenide)]
Synonyms	TMSB4 THYB4 TB4X hCG_1646598
Description	FUNCTION: Plays an important role in the organization of the cytoskeleton . Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization . .; FUNCTION: [Hemoregulatory peptide AcSDKP]: Potent inhibitor of bone marrow derived stem cell differentiation . Acts by inhibits the entry of hematopoietic pluripotent stem cells into the S-phase (By similarity). . FUNCTION: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. .
Accessions	ENST00000380635.5 ENST00000451311.7 ENST00000380636.1 Q0P5P4 Q0P5U7 Q0P5N8 Q0P5T0 P62328 Q0P5Q0 A2VCK8 ENST00000380633.1

TMSB4X report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review