THRAP3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006397Biological processmRNA processing
GO_0048255Biological processmRNA stabilization
GO_0048026Biological processpositive regulation of mRNA splicing, via spliceosome
GO_0000381Biological processregulation of alternative mRNA splicing, via spliceosome
GO_0007623Biological processcircadian rhythm
GO_0008380Biological processRNA splicing
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0042753Biological processpositive regulation of circadian rhythm
GO_0000956Biological processnuclear-transcribed mRNA catabolic process
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0016592Cellular componentmediator complex
GO_0016607Cellular componentnuclear speck
GO_0035145Cellular componentexon-exon junction complex
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0046966Molecular functionnuclear thyroid hormone receptor binding
GO_0003677Molecular functionDNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0003712Molecular functiontranscription coregulator activity
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0042809Molecular functionnuclear vitamin D receptor binding
GO_0051219Molecular functionphosphoprotein binding
GO_0030374Molecular functionnuclear receptor coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTHRAP3
Protein nameThyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150)
THRAP3 protein
Thyroid hormone receptor associated protein 3
SynonymsTRAP150
BCLAF2
DescriptionFUNCTION: Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes . .

AccessionsQ7Z5U1
A0A3B3ITZ9
Q05D20
Q6PJV4
ENST00000469141.6
Q6P0P7
ENST00000648638.1
Q9Y2W1
ENST00000354618.10