SRSF3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	42 studies	50% ± 20%	Explore
B cell	40 studies	49% ± 17%	Explore
natural killer cell	40 studies	52% ± 16%	Explore
fibroblast	40 studies	51% ± 20%	Explore
T cell	37 studies	49% ± 21%	Explore
CD8-positive, alpha-beta T cell	36 studies	51% ± 18%	Explore
macrophage	35 studies	46% ± 17%	Explore
pericyte	34 studies	57% ± 22%	Explore
CD4-positive, alpha-beta T cell	32 studies	51% ± 18%	Explore
smooth muscle cell	28 studies	55% ± 20%	Explore
conventional dendritic cell	28 studies	63% ± 15%	Explore
regulatory T cell	27 studies	50% ± 15%	Explore
classical monocyte	25 studies	50% ± 14%	Explore
dendritic cell	24 studies	54% ± 21%	Explore
non-classical monocyte	24 studies	47% ± 14%	Explore
monocyte	23 studies	46% ± 21%	Explore
endothelial cell of lymphatic vessel	23 studies	50% ± 18%	Explore
plasmacytoid dendritic cell	23 studies	56% ± 16%	Explore
mature NK T cell	22 studies	43% ± 16%	Explore
basal cell	22 studies	53% ± 17%	Explore
epithelial cell	22 studies	50% ± 23%	Explore
mast cell	20 studies	48% ± 18%	Explore
memory B cell	20 studies	44% ± 11%	Explore
naive B cell	19 studies	39% ± 10%	Explore
gamma-delta T cell	18 studies	52% ± 16%	Explore
connective tissue cell	18 studies	61% ± 20%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	39% ± 10%	Explore
ciliated cell	17 studies	44% ± 19%	Explore
plasma cell	16 studies	43% ± 16%	Explore
mucosal invariant T cell	16 studies	45% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	50% ± 14%	Explore
capillary endothelial cell	15 studies	41% ± 16%	Explore
myofibroblast cell	15 studies	56% ± 24%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	50% ± 16%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	45% ± 12%	Explore
myeloid cell	14 studies	51% ± 21%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	44% ± 18%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	49% ± 18%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	52% ± 16%	Explore
secretory cell	12 studies	43% ± 15%	Explore
vein endothelial cell	12 studies	50% ± 13%	Explore
endothelial cell of vascular tree	12 studies	57% ± 17%	Explore
plasmablast	11 studies	58% ± 25%	Explore
endothelial cell of artery	11 studies	45% ± 15%	Explore
goblet cell	11 studies	44% ± 19%	Explore
type I pneumocyte	10 studies	44% ± 20%	Explore
type II pneumocyte	10 studies	40% ± 20%	Explore
innate lymphoid cell	10 studies	53% ± 17%	Explore
club cell	10 studies	36% ± 19%	Explore
progenitor cell	10 studies	67% ± 22%	Explore
abnormal cell	10 studies	47% ± 16%	Explore
mesothelial cell	10 studies	55% ± 25%	Explore
leukocyte	9 studies	57% ± 16%	Explore
microglial cell	9 studies	36% ± 21%	Explore
astrocyte	9 studies	35% ± 16%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	54% ± 19%	Explore
neuron	8 studies	51% ± 22%	Explore
T follicular helper cell	8 studies	54% ± 11%	Explore
platelet	7 studies	22% ± 5%	Explore
neutrophil	7 studies	32% ± 11%	Explore
hematopoietic stem cell	7 studies	67% ± 8%	Explore
precursor B cell	7 studies	68% ± 17%	Explore
brush cell	7 studies	47% ± 18%	Explore
alveolar macrophage	6 studies	36% ± 6%	Explore
ionocyte	6 studies	34% ± 10%	Explore
respiratory goblet cell	6 studies	35% ± 23%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	56% ± 11%	Explore
mononuclear phagocyte	6 studies	57% ± 21%	Explore
kidney loop of Henle epithelial cell	6 studies	36% ± 7%	Explore
epithelial cell of proximal tubule	6 studies	34% ± 18%	Explore
enterocyte	6 studies	38% ± 11%	Explore
erythroblast	6 studies	56% ± 31%	Explore
IgA plasma cell	6 studies	24% ± 7%	Explore
transit amplifying cell	6 studies	52% ± 22%	Explore
immature B cell	6 studies	56% ± 18%	Explore
erythrocyte	6 studies	49% ± 23%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	56% ± 15%	Explore
CD4-positive helper T cell	5 studies	45% ± 18%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	40% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	34% ± 9%	Explore
hematopoietic precursor cell	5 studies	74% ± 18%	Explore
duct epithelial cell	5 studies	35% ± 15%	Explore
exhausted T cell	5 studies	54% ± 18%	Explore
enteroendocrine cell	5 studies	58% ± 25%	Explore
glutamatergic neuron	5 studies	36% ± 10%	Explore
amacrine cell	5 studies	43% ± 22%	Explore
retinal rod cell	5 studies	38% ± 21%	Explore
lymphocyte	5 studies	52% ± 25%	Explore
pro-B cell	5 studies	67% ± 18%	Explore
T-helper 17 cell	5 studies	67% ± 16%	Explore
cardiac muscle cell	5 studies	26% ± 7%	Explore
intermediate monocyte	5 studies	54% ± 22%	Explore
adipocyte	5 studies	20% ± 7%	Explore
granulocyte	5 studies	49% ± 20%	Explore
GABAergic neuron	5 studies	29% ± 6%	Explore
oligodendrocyte precursor cell	5 studies	45% ± 22%	Explore
deuterosomal cell	4 studies	41% ± 1%	Explore
squamous epithelial cell	4 studies	40% ± 22%	Explore
pancreatic A cell	4 studies	58% ± 12%	Explore
glomerular endothelial cell	4 studies	48% ± 16%	Explore
renal alpha-intercalated cell	4 studies	58% ± 22%	Explore
intestinal crypt stem cell	4 studies	54% ± 11%	Explore
IgG plasma cell	4 studies	24% ± 4%	Explore
retinal ganglion cell	4 studies	44% ± 28%	Explore
retinal pigment epithelial cell	4 studies	48% ± 20%	Explore
adventitial cell	4 studies	47% ± 19%	Explore
mucus secreting cell	4 studies	22% ± 4%	Explore
Mueller cell	4 studies	48% ± 15%	Explore
inflammatory macrophage	4 studies	42% ± 18%	Explore
acinar cell	4 studies	40% ± 15%	Explore
muscle cell	4 studies	45% ± 16%	Explore
germinal center B cell	4 studies	61% ± 10%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	57% ± 9%	Explore
luminal cell of prostate epithelium	4 studies	23% ± 7%	Explore
glial cell	4 studies	47% ± 28%	Explore
hepatocyte	4 studies	41% ± 28%	Explore
group 3 innate lymphoid cell	4 studies	66% ± 12%	Explore
keratinocyte	4 studies	50% ± 21%	Explore
T-helper 1 cell	4 studies	67% ± 8%	Explore
double negative thymocyte	4 studies	57% ± 21%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	47% ± 23%	Explore
hillock cell	3 studies	38% ± 13%	Explore
precursor cell	3 studies	74% ± 17%	Explore
pancreatic D cell	3 studies	63% ± 22%	Explore
type B pancreatic cell	3 studies	58% ± 10%	Explore
monocyte-derived dendritic cell	3 studies	68% ± 20%	Explore
podocyte	3 studies	62% ± 16%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	71% ± 24%	Explore
neural crest cell	3 studies	83% ± 15%	Explore
retinal bipolar neuron	3 studies	55% ± 20%	Explore
OFF-bipolar cell	3 studies	25% ± 8%	Explore
ON-bipolar cell	3 studies	24% ± 11%	Explore
renal principal cell	3 studies	48% ± 10%	Explore
extravillous trophoblast	3 studies	61% ± 19%	Explore
placental villous trophoblast	3 studies	61% ± 20%	Explore
neuroendocrine cell	3 studies	48% ± 13%	Explore
Schwann cell	3 studies	54% ± 26%	Explore
retina horizontal cell	3 studies	44% ± 19%	Explore
retinal cone cell	3 studies	56% ± 21%	Explore
serous secreting cell	3 studies	32% ± 11%	Explore
tissue-resident macrophage	3 studies	51% ± 22%	Explore
intraepithelial lymphocyte	3 studies	49% ± 17%	Explore
myoepithelial cell	3 studies	65% ± 3%	Explore
pancreatic ductal cell	3 studies	71% ± 8%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	84% ± 9%	Explore
melanocyte	3 studies	44% ± 20%	Explore
interneuron	3 studies	35% ± 10%	Explore
oligodendrocyte	3 studies	31% ± 6%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	44% ± 6%	Explore
progenitor cell of mammary luminal epithelium	3 studies	60% ± 14%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	20 studies	45% ± 16%	Explore
lung	19 studies	49% ± 17%	Explore
intestine	12 studies	48% ± 23%	Explore
brain	10 studies	32% ± 8%	Explore
kidney	9 studies	42% ± 15%	Explore
eye	9 studies	44% ± 19%	Explore
bone marrow	6 studies	39% ± 17%	Explore
lymph node	6 studies	47% ± 18%	Explore
liver	6 studies	49% ± 21%	Explore
pancreas	5 studies	51% ± 17%	Explore
heart	5 studies	26% ± 10%	Explore
uterus	5 studies	64% ± 17%	Explore
prostate	5 studies	33% ± 12%	Explore
placenta	4 studies	50% ± 21%	Explore
adipose	4 studies	26% ± 6%	Explore
breast	4 studies	59% ± 11%	Explore
adrenal gland	3 studies	39% ± 10%	Explore
esophagus	3 studies	57% ± 26%	Explore
skin	3 studies	51% ± 16%	Explore
thymus	3 studies	71% ± 25%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	17023.82	459 / 459	100%	139.56	1118 / 1118
esophagus	100%	12261.91	1445 / 1445	100%	99.39	183 / 183
ovary	100%	17280.61	180 / 180	100%	103.36	430 / 430
stomach	100%	9483.73	359 / 359	100%	111.08	286 / 286
uterus	100%	14612.15	170 / 170	100%	164.91	459 / 459
lung	100%	12012.54	577 / 578	100%	120.22	1155 / 1155
intestine	100%	13192.58	966 / 966	100%	128.55	526 / 527
bladder	100%	13991.62	21 / 21	100%	135.04	503 / 504
prostate	100%	13321.49	245 / 245	100%	116.63	501 / 502
liver	100%	6250.01	226 / 226	100%	61.26	405 / 406
pancreas	100%	6083.36	327 / 328	100%	97.05	178 / 178
thymus	100%	12833.29	653 / 653	100%	115.75	603 / 605
brain	99%	6815.81	2623 / 2642	100%	109.94	705 / 705
kidney	100%	10056.06	89 / 89	99%	75.43	891 / 901
adrenal gland	100%	9196.42	258 / 258	99%	78.65	227 / 230
skin	100%	14003.32	1809 / 1809	99%	109.38	465 / 472
adipose	100%	17302.42	1204 / 1204	0%	0	0 / 0
blood vessel	100%	14379.46	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	187.11	29 / 29
spleen	100%	12003.54	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	143.70	45 / 45
ureter	0%	0	0 / 0	100%	77.70	1 / 1
muscle	99%	6900.26	796 / 803	0%	0	0 / 0
heart	98%	8344.05	848 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	96%	72.07	77 / 80
peripheral blood	96%	10353.11	890 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0000398	Biological process	mRNA splicing, via spliceosome
GO_0006406	Biological process	mRNA export from nucleus
GO_1990830	Biological process	cellular response to leukemia inhibitory factor
GO_0048024	Biological process	regulation of mRNA splicing, via spliceosome
GO_0031053	Biological process	primary miRNA processing
GO_0016607	Cellular component	nuclear speck
GO_0005654	Cellular component	nucleoplasm
GO_0005737	Cellular component	cytoplasm
GO_0036002	Molecular function	pre-mRNA binding
GO_0070878	Molecular function	primary miRNA binding
GO_0043274	Molecular function	phospholipase binding
GO_0160134	Molecular function	protein-RNA sequence-specific adaptor activity
GO_0005515	Molecular function	protein binding
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	SRSF3
Protein name	Serine and arginine rich splicing factor 3 Serine/arginine-rich splicing factor 3 (Pre-mRNA-splicing factor SRP20) (Splicing factor, arginine/serine-rich 3)
Synonyms	SRP20 SFRS3
Description	FUNCTION: Splicing factor, which binds the consensus motif 5'-C[ACU][AU]C[ACU][AC]C-3' within pre-mRNA and promotes specific exons inclusion during alternative splicing . Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites within exons . Also functions as an adapter involved in mRNA nuclear export . Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity . Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export . .
Accessions	A0A087X2D0 ENST00000613941.4 P84103 ENST00000620941.1 [P84103-1] ENST00000477442.6 [P84103-2] ENST00000373715.11 [P84103-1]

SRSF3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review