RPL11 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1901798Biological processpositive regulation of signal transduction by p53 class mediator
GO_0032435Biological processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_2000059Biological processnegative regulation of ubiquitin-dependent protein catabolic process
GO_0032092Biological processpositive regulation of protein binding
GO_0006412Biological processtranslation
GO_0010628Biological processpositive regulation of gene expression
GO_0000027Biological processribosomal large subunit assembly
GO_0006605Biological processprotein targeting
GO_2000435Biological processnegative regulation of protein neddylation
GO_0042273Biological processribosomal large subunit biogenesis
GO_0050821Biological processprotein stabilization
GO_0034504Biological processprotein localization to nucleus
GO_1901796Biological processregulation of signal transduction by p53 class mediator
GO_1904667Biological processnegative regulation of ubiquitin protein ligase activity
GO_0006364Biological processrRNA processing
GO_0002181Biological processcytoplasmic translation
GO_0005730Cellular componentnucleolus
GO_0022626Cellular componentcytosolic ribosome
GO_0016020Cellular componentmembrane
GO_0070062Cellular componentextracellular exosome
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0022625Cellular componentcytosolic large ribosomal subunit
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_1990948Molecular functionubiquitin ligase inhibitor activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0008097Molecular function5S rRNA binding
GO_0003735Molecular functionstructural constituent of ribosome
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRPL11
Protein nameRibosomal protein L11
Large ribosomal subunit protein uL5 (60S ribosomal protein L11)
Large ribosomal subunit protein uL5 (60S ribosomal protein L11) (CLL-associated antigen KW-12)
SynonymshCG_1739238
DescriptionFUNCTION: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell . The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules . The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain . The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel . As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs . It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 . Promotes nucleolar location of PML (By similarity). .

AccessionsQ5VVD0
ENST00000458455.2
A0A2R8Y447
ENST00000374550.8 [P62913-2]
Q5VVC8
ENST00000467075.2
ENST00000643754.2 [P62913-1]
P62913