RAN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0035281Biological processpre-miRNA export from nucleus
GO_1902570Biological processprotein localization to nucleolus
GO_0021766Biological processhippocampus development
GO_0071389Biological processcellular response to mineralocorticoid stimulus
GO_0006611Biological processprotein export from nucleus
GO_0000278Biological processmitotic cell cycle
GO_0000054Biological processribosomal subunit export from nucleus
GO_0000070Biological processmitotic sister chromatid segregation
GO_0007052Biological processmitotic spindle organization
GO_0046039Biological processGTP metabolic process
GO_0032092Biological processpositive regulation of protein binding
GO_0042307Biological processpositive regulation of protein import into nucleus
GO_0051301Biological processcell division
GO_0030036Biological processactin cytoskeleton organization
GO_0006259Biological processDNA metabolic process
GO_0006606Biological processprotein import into nucleus
GO_0000056Biological processribosomal small subunit export from nucleus
GO_0016032Biological processviral process
GO_0061015Biological processsnRNA import into nucleus
GO_0007286Biological processspermatid development
GO_0000055Biological processribosomal large subunit export from nucleus
GO_0005730Cellular componentnucleolus
GO_0030496Cellular componentmidbody
GO_0036126Cellular componentsperm flagellum
GO_0005643Cellular componentnuclear pore
GO_0016020Cellular componentmembrane
GO_0055037Cellular componentrecycling endosome
GO_0032991Cellular componentprotein-containing complex
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0002177Cellular componentmanchette
GO_0005635Cellular componentnuclear envelope
GO_0005814Cellular componentcentriole
GO_0090543Cellular componentFlemming body
GO_0042565Cellular componentRNA nuclear export complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0001673Cellular componentmale germ cell nucleus
GO_0000785Cellular componentchromatin
GO_0042470Cellular componentmelanosome
GO_0005634Cellular componentnucleus
GO_0019003Molecular functionGDP binding
GO_0019904Molecular functionprotein domain specific binding
GO_0061676Molecular functionimportin-alpha family protein binding
GO_0003682Molecular functionchromatin binding
GO_0045296Molecular functioncadherin binding
GO_0070883Molecular functionpre-miRNA binding
GO_0003925Molecular functionG protein activity
GO_0000287Molecular functionmagnesium ion binding
GO_0005525Molecular functionGTP binding
GO_0003723Molecular functionRNA binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0045505Molecular functiondynein intermediate chain binding
GO_0005049Molecular functionnuclear export signal receptor activity
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameRAN
Protein nameRAN, member RAS oncogene family
GTP-binding nuclear protein Ran (GTPase Ran) (Ras-related nuclear protein)
GTP-binding nuclear protein Ran (EC 3.6.5.-) (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein)
GTP-binding nuclear protein Ran
SynonymshCG_1744585
ARA24
OK/SW-cl.81
DescriptionFUNCTION: GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs . Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis . Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport . Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins . RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation . Required for normal progress through mitosis . The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules . Acts as a negative regulator of the kinase activity of VRK1 and VRK2 . Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases . .

FUNCTION: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. .

FUNCTION: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. .

FUNCTION: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. .

FUNCTION: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. .

AccessionsENST00000535090.5
A0A087X0W0
H0YFC6
P62826
ENST00000448750.7
ENST00000543796.6
ENST00000392367.4
ENST00000536606.5
ENST00000541679.7
B4DV51
ENST00000392369.6
ENST00000541630.5
J3KQE5
F5H018
B5MDF5