Name | Number of supported studies | Average coverage | |
---|---|---|---|
peripheral blood | 20 studies | 48% ± 13% | |
lung | 18 studies | 51% ± 15% | |
intestine | 14 studies | 40% ± 19% | |
kidney | 9 studies | 47% ± 16% | |
eye | 8 studies | 46% ± 14% | |
brain | 8 studies | 35% ± 8% | |
liver | 8 studies | 45% ± 22% | |
bone marrow | 7 studies | 38% ± 18% | |
lymph node | 7 studies | 58% ± 15% | |
uterus | 6 studies | 56% ± 17% | |
pancreas | 5 studies | 61% ± 22% | |
placenta | 4 studies | 62% ± 21% | |
prostate | 4 studies | 61% ± 15% | |
breast | 4 studies | 61% ± 4% | |
ovary | 3 studies | 40% ± 7% | |
adrenal gland | 3 studies | 54% ± 8% | |
esophagus | 3 studies | 62% ± 20% | |
skin | 3 studies | 47% ± 14% | |
thymus | 3 studies | 72% ± 25% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
ovary | 100% | 7126.34 | 180 / 180 | 100% | 197.04 | 430 / 430 |
stomach | 100% | 6843.58 | 359 / 359 | 100% | 217.92 | 286 / 286 |
uterus | 100% | 7632.60 | 170 / 170 | 100% | 259.25 | 459 / 459 |
esophagus | 100% | 10252.83 | 1444 / 1445 | 100% | 198.21 | 183 / 183 |
breast | 100% | 8486.65 | 459 / 459 | 100% | 194.02 | 1116 / 1118 |
intestine | 100% | 8480.19 | 966 / 966 | 100% | 255.29 | 526 / 527 |
lung | 100% | 9094.19 | 576 / 578 | 100% | 218.08 | 1155 / 1155 |
bladder | 100% | 9370.95 | 21 / 21 | 100% | 230.12 | 502 / 504 |
brain | 100% | 8118.96 | 2631 / 2642 | 100% | 172.46 | 705 / 705 |
skin | 100% | 13841.92 | 1809 / 1809 | 100% | 204.85 | 470 / 472 |
thymus | 100% | 7325.09 | 653 / 653 | 99% | 138.38 | 600 / 605 |
prostate | 100% | 6543.10 | 245 / 245 | 99% | 146.84 | 497 / 502 |
kidney | 100% | 7384.28 | 89 / 89 | 98% | 116.61 | 881 / 901 |
pancreas | 98% | 4042.35 | 320 / 328 | 99% | 145.11 | 177 / 178 |
adrenal gland | 100% | 11496.60 | 258 / 258 | 97% | 178.96 | 223 / 230 |
liver | 98% | 4549.76 | 221 / 226 | 96% | 94.47 | 389 / 406 |
eye | 0% | 0 | 0 / 0 | 100% | 156.89 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 387.37 | 29 / 29 |
muscle | 100% | 8715.96 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 9410.73 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 247.90 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 90.78 | 1 / 1 |
adipose | 100% | 9153.30 | 1203 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 8393.17 | 1333 / 1335 | 0% | 0 | 0 / 0 |
heart | 96% | 6253.10 | 828 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 83% | 12048.96 | 767 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0035281 | Biological process | pre-miRNA export from nucleus |
GO_1902570 | Biological process | protein localization to nucleolus |
GO_0021766 | Biological process | hippocampus development |
GO_0071389 | Biological process | cellular response to mineralocorticoid stimulus |
GO_0006611 | Biological process | protein export from nucleus |
GO_0000278 | Biological process | mitotic cell cycle |
GO_0000054 | Biological process | ribosomal subunit export from nucleus |
GO_0000070 | Biological process | mitotic sister chromatid segregation |
GO_0007052 | Biological process | mitotic spindle organization |
GO_0046039 | Biological process | GTP metabolic process |
GO_0032092 | Biological process | positive regulation of protein binding |
GO_0042307 | Biological process | positive regulation of protein import into nucleus |
GO_0051301 | Biological process | cell division |
GO_0030036 | Biological process | actin cytoskeleton organization |
GO_0006259 | Biological process | DNA metabolic process |
GO_0006606 | Biological process | protein import into nucleus |
GO_0000056 | Biological process | ribosomal small subunit export from nucleus |
GO_0016032 | Biological process | viral process |
GO_0061015 | Biological process | snRNA import into nucleus |
GO_0007286 | Biological process | spermatid development |
GO_0000055 | Biological process | ribosomal large subunit export from nucleus |
GO_0005730 | Cellular component | nucleolus |
GO_0030496 | Cellular component | midbody |
GO_0036126 | Cellular component | sperm flagellum |
GO_0005643 | Cellular component | nuclear pore |
GO_0016020 | Cellular component | membrane |
GO_0055037 | Cellular component | recycling endosome |
GO_0032991 | Cellular component | protein-containing complex |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005654 | Cellular component | nucleoplasm |
GO_0002177 | Cellular component | manchette |
GO_0005635 | Cellular component | nuclear envelope |
GO_0005814 | Cellular component | centriole |
GO_0090543 | Cellular component | Flemming body |
GO_0042565 | Cellular component | RNA nuclear export complex |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0001673 | Cellular component | male germ cell nucleus |
GO_0000785 | Cellular component | chromatin |
GO_0042470 | Cellular component | melanosome |
GO_0005634 | Cellular component | nucleus |
GO_0019003 | Molecular function | GDP binding |
GO_0019904 | Molecular function | protein domain specific binding |
GO_0061676 | Molecular function | importin-alpha family protein binding |
GO_0003682 | Molecular function | chromatin binding |
GO_0045296 | Molecular function | cadherin binding |
GO_0070883 | Molecular function | pre-miRNA binding |
GO_0003925 | Molecular function | G protein activity |
GO_0000287 | Molecular function | magnesium ion binding |
GO_0005525 | Molecular function | GTP binding |
GO_0003723 | Molecular function | RNA binding |
GO_0046982 | Molecular function | protein heterodimerization activity |
GO_0045505 | Molecular function | dynein intermediate chain binding |
GO_0005049 | Molecular function | nuclear export signal receptor activity |
GO_0005515 | Molecular function | protein binding |
GO_0003924 | Molecular function | GTPase activity |
Gene name | RAN |
Protein name | RAN, member RAS oncogene family GTP-binding nuclear protein Ran (GTPase Ran) (Ras-related nuclear protein) GTP-binding nuclear protein Ran (EC 3.6.5.-) (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein) GTP-binding nuclear protein Ran |
Synonyms | hCG_1744585 ARA24 OK/SW-cl.81 |
Description | FUNCTION: GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs . Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis . Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport . Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins . RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation . Required for normal progress through mitosis . The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules . Acts as a negative regulator of the kinase activity of VRK1 and VRK2 . Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases . . FUNCTION: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. . FUNCTION: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. . FUNCTION: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. . FUNCTION: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. . |
Accessions | ENST00000535090.5 A0A087X0W0 H0YFC6 P62826 ENST00000448750.7 ENST00000543796.6 ENST00000392367.4 ENST00000536606.5 ENST00000541679.7 B4DV51 ENST00000392369.6 ENST00000541630.5 J3KQE5 F5H018 B5MDF5 |