NAP1L1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	47 studies	49% ± 21%	Explore
B cell	45 studies	57% ± 19%	Explore
fibroblast	44 studies	62% ± 22%	Explore
macrophage	42 studies	48% ± 19%	Explore
T cell	41 studies	49% ± 20%	Explore
pericyte	38 studies	57% ± 23%	Explore
natural killer cell	36 studies	42% ± 15%	Explore
CD8-positive, alpha-beta T cell	36 studies	49% ± 19%	Explore
CD4-positive, alpha-beta T cell	34 studies	57% ± 20%	Explore
smooth muscle cell	31 studies	58% ± 22%	Explore
conventional dendritic cell	30 studies	77% ± 14%	Explore
dendritic cell	28 studies	63% ± 22%	Explore
regulatory T cell	27 studies	58% ± 16%	Explore
classical monocyte	26 studies	51% ± 19%	Explore
non-classical monocyte	25 studies	77% ± 17%	Explore
plasmacytoid dendritic cell	25 studies	64% ± 18%	Explore
monocyte	24 studies	53% ± 19%	Explore
endothelial cell of lymphatic vessel	23 studies	50% ± 17%	Explore
basal cell	23 studies	56% ± 19%	Explore
epithelial cell	23 studies	49% ± 22%	Explore
mast cell	21 studies	51% ± 21%	Explore
ciliated cell	20 studies	62% ± 20%	Explore
memory B cell	20 studies	66% ± 17%	Explore
connective tissue cell	20 studies	65% ± 25%	Explore
naive B cell	19 studies	55% ± 20%	Explore
astrocyte	19 studies	33% ± 12%	Explore
microglial cell	19 studies	39% ± 18%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	18 studies	57% ± 21%	Explore
mature NK T cell	18 studies	38% ± 13%	Explore
gamma-delta T cell	18 studies	49% ± 19%	Explore
plasma cell	16 studies	41% ± 20%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	15 studies	57% ± 19%	Explore
myofibroblast cell	15 studies	67% ± 20%	Explore
mucosal invariant T cell	15 studies	44% ± 11%	Explore
myeloid cell	15 studies	56% ± 26%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	36% ± 17%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	42% ± 18%	Explore
capillary endothelial cell	14 studies	38% ± 15%	Explore
CD4-positive, alpha-beta memory T cell	13 studies	56% ± 21%	Explore
oligodendrocyte precursor cell	13 studies	36% ± 18%	Explore
vein endothelial cell	13 studies	49% ± 19%	Explore
type I pneumocyte	12 studies	36% ± 16%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	54% ± 19%	Explore
glutamatergic neuron	12 studies	52% ± 24%	Explore
oligodendrocyte	12 studies	29% ± 9%	Explore
endothelial cell of artery	12 studies	41% ± 18%	Explore
mesothelial cell	12 studies	62% ± 26%	Explore
endothelial cell of vascular tree	12 studies	59% ± 13%	Explore
type II pneumocyte	11 studies	35% ± 17%	Explore
platelet	11 studies	72% ± 17%	Explore
secretory cell	11 studies	45% ± 19%	Explore
GABAergic neuron	11 studies	44% ± 22%	Explore
effector memory CD8-positive, alpha-beta T cell	11 studies	46% ± 19%	Explore
progenitor cell	11 studies	59% ± 30%	Explore
innate lymphoid cell	11 studies	59% ± 22%	Explore
neuron	11 studies	53% ± 19%	Explore
plasmablast	10 studies	51% ± 18%	Explore
club cell	10 studies	33% ± 16%	Explore
leukocyte	10 studies	60% ± 20%	Explore
abnormal cell	10 studies	58% ± 19%	Explore
goblet cell	10 studies	32% ± 14%	Explore
T follicular helper cell	9 studies	62% ± 18%	Explore
hematopoietic stem cell	9 studies	80% ± 22%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	52% ± 18%	Explore
amacrine cell	8 studies	47% ± 21%	Explore
adipocyte	8 studies	27% ± 9%	Explore
alveolar macrophage	7 studies	48% ± 18%	Explore
epithelial cell of proximal tubule	7 studies	33% ± 22%	Explore
transit amplifying cell	7 studies	40% ± 18%	Explore
precursor B cell	7 studies	61% ± 21%	Explore
erythrocyte	7 studies	40% ± 17%	Explore
hematopoietic precursor cell	6 studies	75% ± 26%	Explore
ionocyte	6 studies	38% ± 15%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	66% ± 11%	Explore
mononuclear phagocyte	6 studies	67% ± 23%	Explore
kidney loop of Henle epithelial cell	6 studies	32% ± 10%	Explore
neutrophil	6 studies	42% ± 13%	Explore
enteroendocrine cell	6 studies	62% ± 22%	Explore
erythroblast	6 studies	49% ± 31%	Explore
IgG plasma cell	6 studies	20% ± 3%	Explore
interneuron	6 studies	53% ± 22%	Explore
retinal ganglion cell	6 studies	76% ± 26%	Explore
retinal rod cell	6 studies	32% ± 13%	Explore
lymphocyte	6 studies	46% ± 22%	Explore
immature B cell	6 studies	68% ± 18%	Explore
retina horizontal cell	6 studies	55% ± 22%	Explore
cardiac muscle cell	6 studies	27% ± 10%	Explore
Mueller cell	6 studies	52% ± 14%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	67% ± 15%	Explore
CD4-positive helper T cell	5 studies	50% ± 18%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	56% ± 27%	Explore
respiratory goblet cell	5 studies	31% ± 20%	Explore
renal alpha-intercalated cell	5 studies	55% ± 20%	Explore
megakaryocyte	5 studies	88% ± 12%	Explore
intestinal crypt stem cell	5 studies	44% ± 15%	Explore
glial cell	5 studies	41% ± 27%	Explore
pro-B cell	5 studies	71% ± 22%	Explore
retinal cone cell	5 studies	38% ± 17%	Explore
adventitial cell	5 studies	38% ± 11%	Explore
mucus secreting cell	5 studies	22% ± 4%	Explore
double negative thymocyte	5 studies	68% ± 22%	Explore
intermediate monocyte	5 studies	63% ± 27%	Explore
granulocyte	5 studies	64% ± 16%	Explore
deuterosomal cell	4 studies	74% ± 14%	Explore
precursor cell	4 studies	59% ± 24%	Explore
pancreatic A cell	4 studies	71% ± 7%	Explore
type B pancreatic cell	4 studies	72% ± 19%	Explore
exhausted T cell	4 studies	51% ± 10%	Explore
glomerular endothelial cell	4 studies	34% ± 16%	Explore
IgA plasma cell	4 studies	24% ± 8%	Explore
retinal bipolar neuron	4 studies	42% ± 19%	Explore
granule cell	4 studies	30% ± 8%	Explore
OFF-bipolar cell	4 studies	48% ± 31%	Explore
GABAergic amacrine cell	4 studies	48% ± 14%	Explore
glycinergic amacrine cell	4 studies	34% ± 10%	Explore
retinal pigment epithelial cell	4 studies	54% ± 23%	Explore
ON-bipolar cell	4 studies	47% ± 32%	Explore
acinar cell	4 studies	50% ± 14%	Explore
chondrocyte	4 studies	41% ± 26%	Explore
muscle cell	4 studies	57% ± 13%	Explore
germinal center B cell	4 studies	63% ± 14%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	48% ± 6%	Explore
myoepithelial cell	4 studies	57% ± 19%	Explore
hepatocyte	4 studies	40% ± 30%	Explore
group 3 innate lymphoid cell	4 studies	71% ± 9%	Explore
T-helper 17 cell	4 studies	75% ± 16%	Explore
T-helper 1 cell	4 studies	72% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	33% ± 4%	Explore
duct epithelial cell	3 studies	34% ± 10%	Explore
hillock cell	3 studies	32% ± 11%	Explore
pancreatic D cell	3 studies	69% ± 13%	Explore
monocyte-derived dendritic cell	3 studies	80% ± 16%	Explore
podocyte	3 studies	67% ± 21%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	74% ± 26%	Explore
enterocyte	3 studies	30% ± 17%	Explore
neural crest cell	3 studies	90% ± 10%	Explore
GABAergic interneuron	3 studies	39% ± 7%	Explore
renal principal cell	3 studies	37% ± 9%	Explore
thymocyte	3 studies	72% ± 18%	Explore
extravillous trophoblast	3 studies	68% ± 8%	Explore
placental villous trophoblast	3 studies	72% ± 16%	Explore
common myeloid progenitor	3 studies	60% ± 27%	Explore
neuroendocrine cell	3 studies	67% ± 14%	Explore
Schwann cell	3 studies	48% ± 12%	Explore
serous secreting cell	3 studies	41% ± 3%	Explore
tissue-resident macrophage	3 studies	50% ± 23%	Explore
intraepithelial lymphocyte	3 studies	45% ± 19%	Explore
rod bipolar cell	3 studies	47% ± 5%	Explore
inflammatory macrophage	3 studies	49% ± 15%	Explore
luminal cell of prostate epithelium	3 studies	36% ± 14%	Explore
pancreatic ductal cell	3 studies	69% ± 6%	Explore
ependymal cell	3 studies	39% ± 17%	Explore
granulocyte monocyte progenitor cell	3 studies	79% ± 19%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	95% ± 4%	Explore
melanocyte	3 studies	43% ± 6%	Explore
keratinocyte	3 studies	51% ± 3%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	66% ± 13%	Explore
double-positive, alpha-beta thymocyte	3 studies	69% ± 12%	Explore
progenitor cell of mammary luminal epithelium	3 studies	63% ± 13%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	21 studies	51% ± 18%	Explore
lung	20 studies	53% ± 18%	Explore
brain	20 studies	40% ± 18%	Explore
intestine	11 studies	49% ± 24%	Explore
eye	11 studies	43% ± 13%	Explore
kidney	9 studies	45% ± 20%	Explore
bone marrow	7 studies	50% ± 28%	Explore
lymph node	6 studies	61% ± 15%	Explore
liver	6 studies	49% ± 20%	Explore
pancreas	5 studies	60% ± 20%	Explore
heart	5 studies	27% ± 11%	Explore
uterus	5 studies	64% ± 18%	Explore
adipose	5 studies	27% ± 9%	Explore
placenta	4 studies	61% ± 18%	Explore
breast	4 studies	56% ± 8%	Explore
prostate	4 studies	53% ± 22%	Explore
adrenal gland	3 studies	41% ± 14%	Explore
esophagus	3 studies	54% ± 26%	Explore
skin	3 studies	40% ± 15%	Explore
thymus	3 studies	69% ± 29%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	22867.92	245 / 245	100%	83.74	502 / 502
brain	100%	18865.41	2639 / 2642	100%	96.35	705 / 705
thymus	100%	16733.49	653 / 653	100%	85.45	604 / 605
breast	100%	25272.36	459 / 459	100%	82.35	1116 / 1118
uterus	100%	28482.82	170 / 170	100%	82.03	458 / 459
ovary	100%	46994.25	180 / 180	100%	72.11	429 / 430
lung	100%	30411.02	578 / 578	100%	68.70	1152 / 1155
skin	100%	19599.01	1807 / 1809	100%	95.74	470 / 472
bladder	100%	23908.33	21 / 21	99%	61.33	500 / 504
esophagus	100%	20275.34	1445 / 1445	99%	50.45	181 / 183
adrenal gland	100%	22361.18	258 / 258	98%	74.80	226 / 230
kidney	100%	12979.58	89 / 89	98%	60.82	881 / 901
intestine	100%	19432.93	964 / 966	98%	63.57	514 / 527
stomach	99%	12754.23	356 / 359	98%	56.40	280 / 286
pancreas	95%	8399.75	313 / 328	99%	62.22	177 / 178
liver	58%	3308.48	130 / 226	86%	34.62	349 / 406
adipose	100%	25951.92	1204 / 1204	0%	0	0 / 0
blood vessel	100%	23007.63	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	160.40	29 / 29
spleen	100%	21693.95	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	70.04	45 / 45
ureter	0%	0	0 / 0	100%	18.86	1 / 1
muscle	100%	24343.86	802 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	99%	74.54	79 / 80
heart	95%	15746.67	819 / 861	0%	0	0 / 0
peripheral blood	81%	19116.29	756 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006334	Biological process	nucleosome assembly
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0050769	Biological process	positive regulation of neurogenesis
GO_2000179	Biological process	positive regulation of neural precursor cell proliferation
GO_0007399	Biological process	nervous system development
GO_0006260	Biological process	DNA replication
GO_0042470	Cellular component	melanosome
GO_0000785	Cellular component	chromatin
GO_0016020	Cellular component	membrane
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0005515	Molecular function	protein binding
GO_0140713	Molecular function	histone chaperone activity
GO_0042393	Molecular function	histone binding
GO_0003682	Molecular function	chromatin binding
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	NAP1L1
Protein name	Nucleosome assembly protein 1 like 1 (Nucleosome assembly protein 1-like 1, isoform CRA_e) (cDNA FLJ59349, highly similar to Nucleosome assembly protein 1-like 1) Nucleosome assembly protein 1 like 1 Nucleosome assembly protein 1 like 1 (cDNA FLJ58569, highly similar to Nucleosome assembly protein 1-like 1) Nucleosome assembly protein 1-like 1 (NAP-1-related protein) (hNRP)
Synonyms	NRP hCG_2015037
Description	FUNCTION: Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly . Participates also in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair . Stimulates also homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair . Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity). .; FUNCTION: (Microbial infection) Positively regulates Epstein-Barr virus reactivation in epithelial cells through the induction of viral BZLF1 expression. .; FUNCTION: (Microbial infection) Together with human herpesvirus 8 protein LANA1, assists the proper assembly of the nucleosome on the replicated viral DNA. .
Accessions	F8W0J6 ENST00000549596.5 [P55209-2] ENST00000552056.5 ENST00000551992.5 ENST00000552342.5 ENST00000547479.5 ENST00000550934.5 F8VV59 ENST00000551524.5 H0YHC3 ENST00000618691.5 [P55209-1] F8W020 H0YH88 ENST00000431879.7 [P55209-3] H0YIV4 ENST00000552147.5 ENST00000542344.5 F5H4R6 F8W543 ENST00000393263.7 [P55209-1] B7Z9C2 F8W118 ENST00000547529.6 F8VVB5 F8VUX1 F8VRJ2 F8VXI6 ENST00000544816.5 ENST00000547704.5 ENST00000548044.5 F8VY35 B7Z4K9 ENST00000548273.5 ENST00000535020.6 P55209 ENST00000551600.5 ENST00000547773.5

NAP1L1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review