HMGN1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	44 studies	57% ± 19%	Explore
natural killer cell	38 studies	54% ± 16%	Explore
fibroblast	37 studies	44% ± 23%	Explore
endothelial cell	35 studies	45% ± 20%	Explore
CD8-positive, alpha-beta T cell	35 studies	54% ± 21%	Explore
macrophage	34 studies	44% ± 16%	Explore
T cell	33 studies	53% ± 21%	Explore
CD4-positive, alpha-beta T cell	32 studies	58% ± 19%	Explore
conventional dendritic cell	29 studies	67% ± 16%	Explore
regulatory T cell	27 studies	57% ± 16%	Explore
dendritic cell	26 studies	53% ± 24%	Explore
plasmacytoid dendritic cell	24 studies	68% ± 17%	Explore
pericyte	24 studies	38% ± 24%	Explore
epithelial cell	22 studies	64% ± 24%	Explore
mast cell	21 studies	50% ± 20%	Explore
basal cell	21 studies	60% ± 19%	Explore
smooth muscle cell	20 studies	44% ± 23%	Explore
mature NK T cell	20 studies	47% ± 16%	Explore
memory B cell	20 studies	61% ± 9%	Explore
classical monocyte	20 studies	30% ± 14%	Explore
monocyte	19 studies	42% ± 19%	Explore
endothelial cell of lymphatic vessel	19 studies	51% ± 18%	Explore
gamma-delta T cell	19 studies	54% ± 19%	Explore
naive B cell	19 studies	57% ± 12%	Explore
non-classical monocyte	19 studies	31% ± 13%	Explore
plasma cell	17 studies	49% ± 17%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	51% ± 13%	Explore
ciliated cell	17 studies	58% ± 20%	Explore
connective tissue cell	16 studies	59% ± 25%	Explore
mucosal invariant T cell	15 studies	42% ± 14%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	49% ± 13%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	50% ± 16%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	57% ± 12%	Explore
myofibroblast cell	14 studies	53% ± 27%	Explore
myeloid cell	14 studies	51% ± 20%	Explore
plasmablast	12 studies	61% ± 23%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	55% ± 17%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	52% ± 15%	Explore
secretory cell	12 studies	65% ± 19%	Explore
capillary endothelial cell	12 studies	33% ± 22%	Explore
vein endothelial cell	12 studies	44% ± 22%	Explore
endothelial cell of vascular tree	12 studies	39% ± 14%	Explore
effector memory CD8-positive, alpha-beta T cell	11 studies	44% ± 20%	Explore
innate lymphoid cell	11 studies	54% ± 18%	Explore
progenitor cell	11 studies	67% ± 29%	Explore
endothelial cell of artery	11 studies	46% ± 19%	Explore
microglial cell	11 studies	41% ± 18%	Explore
type I pneumocyte	10 studies	43% ± 22%	Explore
type II pneumocyte	10 studies	47% ± 24%	Explore
mesothelial cell	10 studies	64% ± 29%	Explore
astrocyte	10 studies	38% ± 15%	Explore
club cell	9 studies	59% ± 23%	Explore
platelet	9 studies	37% ± 10%	Explore
leukocyte	9 studies	57% ± 18%	Explore
abnormal cell	9 studies	65% ± 14%	Explore
goblet cell	9 studies	51% ± 20%	Explore
T follicular helper cell	9 studies	63% ± 16%	Explore
retinal rod cell	9 studies	79% ± 16%	Explore
oligodendrocyte precursor cell	9 studies	50% ± 19%	Explore
amacrine cell	8 studies	45% ± 25%	Explore
retinal cone cell	8 studies	68% ± 27%	Explore
hematopoietic stem cell	8 studies	72% ± 17%	Explore
ionocyte	7 studies	66% ± 18%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	60% ± 16%	Explore
epithelial cell of proximal tubule	7 studies	44% ± 20%	Explore
IgG plasma cell	7 studies	27% ± 12%	Explore
transit amplifying cell	7 studies	53% ± 27%	Explore
precursor B cell	7 studies	69% ± 17%	Explore
brush cell	7 studies	58% ± 26%	Explore
neuron	7 studies	59% ± 20%	Explore
alveolar macrophage	6 studies	32% ± 7%	Explore
hematopoietic precursor cell	6 studies	66% ± 29%	Explore
respiratory goblet cell	6 studies	50% ± 22%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	62% ± 15%	Explore
mononuclear phagocyte	6 studies	45% ± 19%	Explore
kidney loop of Henle epithelial cell	6 studies	49% ± 12%	Explore
renal alpha-intercalated cell	6 studies	71% ± 11%	Explore
megakaryocyte	6 studies	62% ± 25%	Explore
enterocyte	6 studies	43% ± 18%	Explore
intestinal crypt stem cell	6 studies	55% ± 25%	Explore
IgA plasma cell	6 studies	27% ± 12%	Explore
interneuron	6 studies	44% ± 17%	Explore
immature B cell	6 studies	71% ± 13%	Explore
erythrocyte	6 studies	48% ± 25%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	63% ± 14%	Explore
glutamatergic neuron	6 studies	44% ± 15%	Explore
oligodendrocyte	6 studies	28% ± 7%	Explore
CD4-positive helper T cell	5 studies	43% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	37% ± 10%	Explore
exhausted T cell	5 studies	66% ± 12%	Explore
neutrophil	5 studies	35% ± 13%	Explore
enteroendocrine cell	5 studies	62% ± 25%	Explore
erythroblast	5 studies	59% ± 23%	Explore
retinal bipolar neuron	5 studies	50% ± 26%	Explore
pro-B cell	5 studies	73% ± 17%	Explore
T-helper 17 cell	5 studies	71% ± 16%	Explore
group 3 innate lymphoid cell	5 studies	77% ± 8%	Explore
double negative thymocyte	5 studies	64% ± 17%	Explore
granulocyte	5 studies	55% ± 20%	Explore
GABAergic neuron	5 studies	51% ± 12%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	44% ± 14%	Explore
deuterosomal cell	4 studies	44% ± 13%	Explore
duct epithelial cell	4 studies	64% ± 1%	Explore
precursor cell	4 studies	65% ± 26%	Explore
pancreatic A cell	4 studies	77% ± 10%	Explore
type B pancreatic cell	4 studies	71% ± 14%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	77% ± 20%	Explore
retinal ganglion cell	4 studies	33% ± 8%	Explore
glial cell	4 studies	43% ± 27%	Explore
OFF-bipolar cell	4 studies	32% ± 12%	Explore
ON-bipolar cell	4 studies	35% ± 12%	Explore
GABAergic amacrine cell	4 studies	30% ± 14%	Explore
glycinergic amacrine cell	4 studies	32% ± 10%	Explore
lymphocyte	4 studies	56% ± 25%	Explore
retina horizontal cell	4 studies	60% ± 16%	Explore
adventitial cell	4 studies	25% ± 9%	Explore
mucus secreting cell	4 studies	46% ± 12%	Explore
Mueller cell	4 studies	53% ± 14%	Explore
acinar cell	4 studies	48% ± 24%	Explore
muscle cell	4 studies	32% ± 12%	Explore
germinal center B cell	4 studies	86% ± 7%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	88% ± 7%	Explore
luminal cell of prostate epithelium	4 studies	60% ± 26%	Explore
hepatocyte	4 studies	39% ± 29%	Explore
T-helper 1 cell	4 studies	72% ± 8%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	57% ± 25%	Explore
squamous epithelial cell	3 studies	43% ± 27%	Explore
pancreatic D cell	3 studies	74% ± 18%	Explore
monocyte-derived dendritic cell	3 studies	65% ± 26%	Explore
podocyte	3 studies	78% ± 14%	Explore
neural crest cell	3 studies	89% ± 11%	Explore
renal principal cell	3 studies	56% ± 6%	Explore
thymocyte	3 studies	49% ± 34%	Explore
extravillous trophoblast	3 studies	85% ± 6%	Explore
placental villous trophoblast	3 studies	82% ± 15%	Explore
neuroendocrine cell	3 studies	65% ± 22%	Explore
retinal pigment epithelial cell	3 studies	32% ± 17%	Explore
serous secreting cell	3 studies	60% ± 2%	Explore
intraepithelial lymphocyte	3 studies	66% ± 19%	Explore
rod bipolar cell	3 studies	54% ± 8%	Explore
cardiac muscle cell	3 studies	21% ± 5%	Explore
intermediate monocyte	3 studies	47% ± 19%	Explore
myoepithelial cell	3 studies	62% ± 16%	Explore
IgM plasma cell	3 studies	41% ± 15%	Explore
pancreatic ductal cell	3 studies	81% ± 8%	Explore
neural progenitor cell	3 studies	42% ± 20%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	90% ± 6%	Explore
keratinocyte	3 studies	54% ± 3%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	60% ± 4%	Explore
progenitor cell of mammary luminal epithelium	3 studies	66% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	19 studies	49% ± 19%	Explore
peripheral blood	19 studies	47% ± 14%	Explore
intestine	13 studies	47% ± 25%	Explore
brain	13 studies	37% ± 12%	Explore
eye	12 studies	48% ± 24%	Explore
kidney	9 studies	48% ± 18%	Explore
bone marrow	6 studies	41% ± 17%	Explore
lymph node	6 studies	60% ± 16%	Explore
liver	6 studies	43% ± 15%	Explore
pancreas	5 studies	62% ± 24%	Explore
placenta	4 studies	62% ± 26%	Explore
uterus	4 studies	63% ± 17%	Explore
prostate	4 studies	52% ± 20%	Explore
breast	4 studies	56% ± 8%	Explore
adrenal gland	3 studies	46% ± 19%	Explore
skin	3 studies	37% ± 9%	Explore
thymus	3 studies	68% ± 33%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	5563.54	459 / 459	100%	149.50	1118 / 1118
esophagus	100%	7002.92	1445 / 1445	100%	81.25	183 / 183
lung	100%	5947.04	578 / 578	100%	97.53	1155 / 1155
ovary	100%	7332.23	180 / 180	100%	113.60	430 / 430
pancreas	100%	4133.57	328 / 328	100%	82.01	178 / 178
stomach	100%	4411.38	359 / 359	100%	83.98	286 / 286
uterus	100%	5840.23	170 / 170	100%	144.02	459 / 459
thymus	100%	7740.70	653 / 653	100%	126.37	604 / 605
intestine	100%	5652.65	966 / 966	100%	92.07	526 / 527
brain	100%	3811.31	2639 / 2642	100%	82.42	704 / 705
bladder	100%	5664.43	21 / 21	100%	112.85	502 / 504
prostate	100%	7422.85	245 / 245	100%	82.70	500 / 502
skin	100%	6244.53	1808 / 1809	98%	78.41	462 / 472
kidney	100%	6088.00	89 / 89	97%	60.40	876 / 901
adrenal gland	100%	4327.37	258 / 258	94%	42.72	217 / 230
liver	100%	2385.22	226 / 226	92%	45.59	375 / 406
lymph node	0%	0	0 / 0	100%	182.14	29 / 29
spleen	100%	6621.69	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	113.58	45 / 45
ureter	0%	0	0 / 0	100%	70.39	1 / 1
adipose	100%	3811.46	1201 / 1204	0%	0	0 / 0
blood vessel	99%	3525.81	1325 / 1335	0%	0	0 / 0
heart	97%	2616.10	838 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	94%	48.83	75 / 80
peripheral blood	87%	5074.03	811 / 929	0%	0	0 / 0
muscle	60%	827.50	482 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006325	Biological process	chromatin organization
GO_0032786	Biological process	positive regulation of DNA-templated transcription, elongation
GO_0048597	Biological process	post-embryonic camera-type eye morphogenesis
GO_0010225	Biological process	response to UV-C
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0000720	Biological process	pyrimidine dimer repair by nucleotide-excision repair
GO_0010224	Biological process	response to UV-B
GO_0050678	Biological process	regulation of epithelial cell proliferation
GO_0040034	Biological process	regulation of development, heterochronic
GO_0006283	Biological process	transcription-coupled nucleotide-excision repair
GO_0005654	Cellular component	nucleoplasm
GO_0001674	Cellular component	female germ cell nucleus
GO_0005737	Cellular component	cytoplasm
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0003682	Molecular function	chromatin binding
GO_0031492	Molecular function	nucleosomal DNA binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	HMGN1
Protein name	High mobility group nucleosome binding domain 1 (High-mobility group nucleosome binding domain 1, isoform CRA_d) Non-histone chromosomal protein HMG-14 (High mobility group nucleosome-binding domain-containing protein 1) High mobility group nucleosome binding domain 1 High-mobility group nucleosome binding domain 1
Synonyms	HMG14 hCG_401225
Description	FUNCTION: Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity). .
Accessions	ENST00000288344.14 ENST00000380749.10 P05114 ENST00000431390.5 F2Z2W6 ENST00000419378.5 Q6NSG7 H7BXJ5 Q3B790 A0A494C035 ENST00000652622.1 ENST00000443046.5 A6NEL0 ENST00000380747.5 ENST00000436324.5 F2Z2Y5 ENST00000380748.5 A6NL93

HMGN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review