GAPDH report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050832Biological processdefense response to fungus
GO_0006096Biological processglycolytic process
GO_0010951Biological processnegative regulation of endopeptidase activity
GO_0032481Biological processpositive regulation of type I interferon production
GO_0051402Biological processneuron apoptotic process
GO_0031640Biological processkilling of cells of another organism
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0035606Biological processpeptidyl-cysteine S-trans-nitrosylation
GO_0050821Biological processprotein stabilization
GO_0000226Biological processmicrotubule cytoskeleton organization
GO_0061844Biological processantimicrobial humoral immune response mediated by antimicrobial peptide
GO_0001819Biological processpositive regulation of cytokine production
GO_0016241Biological processregulation of macroautophagy
GO_0051873Biological processkilling by host of symbiont cells
GO_0006006Biological processglucose metabolic process
GO_0017148Biological processnegative regulation of translation
GO_0071346Biological processcellular response to type II interferon
GO_0097452Cellular componentGAIT complex
GO_0031982Cellular componentvesicle
GO_0005886Cellular componentplasma membrane
GO_0005811Cellular componentlipid droplet
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_1990904Cellular componentribonucleoprotein complex
GO_0031965Cellular componentnuclear membrane
GO_0005634Cellular componentnucleus
GO_0051287Molecular functionNAD binding
GO_0004365Molecular functionglyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO_0042802Molecular functionidentical protein binding
GO_0035605Molecular functionpeptidyl-cysteine S-nitrosylase activity
GO_0019828Molecular functionaspartic-type endopeptidase inhibitor activity
GO_0050661Molecular functionNADP binding
GO_0008017Molecular functionmicrotubule binding
GO_0097718Molecular functiondisordered domain specific binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGAPDH
Protein namePeptidyl-cysteine S-nitrosylase GAPDH
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-)
SynonymsCDABP0047
GAPD
OK/SW-cl.12
DescriptionFUNCTION: Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively . Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate . Modulates the organization and assembly of the cytoskeleton (By similarity). Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes . Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation . Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively . Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis (By similarity). Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). .

AccessionsE7EUT5
P04406
ENST00000619601.1 [P04406-2]
ENST00000229239.10 [P04406-1]
ENST00000396859.5 [P04406-1]
ENST00000396858.5 [P04406-2]
Q0QET7
ENST00000396856.5
ENST00000396861.5 [P04406-1]