EIF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1905746Biological processpositive regulation of mRNA cis splicing, via spliceosome
GO_0006446Biological processregulation of translational initiation
GO_0006413Biological processtranslational initiation
GO_0033290Cellular componenteukaryotic 48S preinitiation complex
GO_0043614Cellular componentmulti-eIF complex
GO_0016282Cellular componenteukaryotic 43S preinitiation complex
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0003743Molecular functiontranslation initiation factor activity
GO_0008135Molecular functiontranslation factor activity, RNA binding
GO_0043024Molecular functionribosomal small subunit binding
GO_0005515Molecular functionprotein binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameEIF1
Protein nameEukaryotic translation initiation factor 1 (eIF1) (A121) (Protein translation factor SUI1 homolog) (Sui1iso1)
Eukaryotic translation initiation factor 1
Eukaryotic translation initiation factor 1 (Protein translation factor SUI1 homolog)
SynonymshCG_1771529
SUI1
DescriptionFUNCTION: Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon . Together with eIF1A (EIF1AX), EIF1 facilitates scanning and is essential for start codon recognition on the basis of AUG nucleotide context and location relative to the 5'-cap . Participates to initiation codon selection by influencing the conformation of the 40S ribosomal subunit and the positions of bound mRNA and initiator tRNA; this is possible after its binding to the interface surface of the platform of the 40S ribosomal subunit close to the P-site . Together with eIF1A (EIF1AX), also regulates the opening and closing of the mRNA binding channel, which ensures mRNA recruitment, scanning and the fidelity of initiation codon selection . Continuously monitors and protects against premature and partial base-pairing of codons in the 5'-UTR with the anticodon of initiator tRNA . Together with eIF1A (EIF1AX), acts for ribosomal scanning, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes . Interacts with EIF4G1, which in a mutual exclusive interaction associates either with EIF1 or with EIF4E on a common binding site . EIF4G1-EIF1 complex promotes ribosome scanning (on both short and long 5'UTR), leaky scanning (on short 5'UTR) which is the bypass of the initial start codon, and discrimination against cap-proximal AUG . Is probably maintained within the 43S PIC in open conformation thanks to eIF1A-EIF5 interaction . Once the correct start codon is reached, EIF1 is physically excluded from the decoding site, shifting the PIC into the closed conformation and arresting it at the start codon . .

AccessionsQ6IAV3
ENST00000591776.5
K7EM18
ENST00000586699.1
P41567
ENST00000469257.2
K7EQP2