EEF1A1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	52 studies	93% ± 17%	Explore
endothelial cell	51 studies	78% ± 26%	Explore
natural killer cell	48 studies	92% ± 18%	Explore
fibroblast	46 studies	83% ± 27%	Explore
macrophage	45 studies	86% ± 23%	Explore
T cell	44 studies	86% ± 25%	Explore
CD8-positive, alpha-beta T cell	41 studies	90% ± 20%	Explore
pericyte	38 studies	83% ± 27%	Explore
CD4-positive, alpha-beta T cell	38 studies	92% ± 18%	Explore
plasmacytoid dendritic cell	33 studies	98% ± 5%	Explore
smooth muscle cell	32 studies	81% ± 28%	Explore
conventional dendritic cell	31 studies	98% ± 3%	Explore
dendritic cell	29 studies	91% ± 18%	Explore
mast cell	28 studies	84% ± 24%	Explore
plasma cell	28 studies	90% ± 18%	Explore
classical monocyte	28 studies	94% ± 10%	Explore
epithelial cell	28 studies	86% ± 24%	Explore
endothelial cell of lymphatic vessel	27 studies	88% ± 21%	Explore
non-classical monocyte	27 studies	97% ± 7%	Explore
regulatory T cell	27 studies	97% ± 7%	Explore
monocyte	26 studies	86% ± 22%	Explore
mature NK T cell	26 studies	90% ± 17%	Explore
basal cell	25 studies	84% ± 25%	Explore
gamma-delta T cell	22 studies	97% ± 6%	Explore
memory B cell	21 studies	99% ± 3%	Explore
naive B cell	20 studies	94% ± 17%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	19 studies	93% ± 19%	Explore
connective tissue cell	19 studies	92% ± 18%	Explore
ciliated cell	18 studies	85% ± 19%	Explore
mucosal invariant T cell	18 studies	93% ± 19%	Explore
astrocyte	18 studies	47% ± 28%	Explore
capillary endothelial cell	17 studies	82% ± 19%	Explore
CD16-positive, CD56-dim natural killer cell, human	16 studies	89% ± 23%	Explore
neutrophil	16 studies	63% ± 29%	Explore
endothelial cell of artery	16 studies	87% ± 18%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	94% ± 13%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	15 studies	99% ± 1%	Explore
myofibroblast cell	15 studies	95% ± 11%	Explore
vein endothelial cell	15 studies	89% ± 15%	Explore
microglial cell	15 studies	62% ± 31%	Explore
myeloid cell	15 studies	82% ± 27%	Explore
erythrocyte	14 studies	76% ± 23%	Explore
CD4-positive, alpha-beta memory T cell	13 studies	97% ± 4%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	96% ± 8%	Explore
mesothelial cell	13 studies	83% ± 24%	Explore
endothelial cell of vascular tree	13 studies	91% ± 16%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	90% ± 17%	Explore
innate lymphoid cell	12 studies	98% ± 3%	Explore
plasmablast	12 studies	97% ± 4%	Explore
secretory cell	12 studies	92% ± 16%	Explore
leukocyte	12 studies	83% ± 28%	Explore
oligodendrocyte	12 studies	38% ± 14%	Explore
progenitor cell	12 studies	83% ± 28%	Explore
goblet cell	12 studies	86% ± 17%	Explore
type I pneumocyte	11 studies	81% ± 24%	Explore
club cell	11 studies	83% ± 27%	Explore
glutamatergic neuron	11 studies	45% ± 19%	Explore
type II pneumocyte	10 studies	83% ± 23%	Explore
T follicular helper cell	10 studies	100% ± 0%	Explore
oligodendrocyte precursor cell	10 studies	48% ± 25%	Explore
abnormal cell	10 studies	89% ± 24%	Explore
IgG plasma cell	10 studies	91% ± 12%	Explore
hematopoietic stem cell	10 studies	87% ± 26%	Explore
platelet	9 studies	77% ± 16%	Explore
GABAergic neuron	9 studies	43% ± 20%	Explore
IgA plasma cell	9 studies	88% ± 17%	Explore
neuron	9 studies	69% ± 29%	Explore
respiratory goblet cell	8 studies	76% ± 30%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	98% ± 5%	Explore
mononuclear phagocyte	8 studies	81% ± 27%	Explore
interneuron	8 studies	60% ± 17%	Explore
enterocyte	8 studies	83% ± 19%	Explore
retinal rod cell	8 studies	72% ± 21%	Explore
alveolar macrophage	7 studies	82% ± 27%	Explore
ionocyte	7 studies	90% ± 19%	Explore
effector CD4-positive, alpha-beta T cell	7 studies	99% ± 2%	Explore
epithelial cell of proximal tubule	7 studies	91% ± 16%	Explore
enteroendocrine cell	7 studies	95% ± 5%	Explore
erythroblast	7 studies	79% ± 24%	Explore
transit amplifying cell	7 studies	82% ± 26%	Explore
retinal ganglion cell	7 studies	83% ± 18%	Explore
retinal cone cell	7 studies	80% ± 19%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	6 studies	84% ± 29%	Explore
kidney loop of Henle epithelial cell	6 studies	91% ± 18%	Explore
renal alpha-intercalated cell	6 studies	100% ± 0%	Explore
intestinal crypt stem cell	6 studies	77% ± 32%	Explore
lymphocyte	6 studies	78% ± 32%	Explore
precursor B cell	6 studies	100% ± 0%	Explore
brush cell	6 studies	92% ± 8%	Explore
glial cell	6 studies	83% ± 23%	Explore
immature B cell	6 studies	100% ± 0%	Explore
amacrine cell	6 studies	71% ± 15%	Explore
adipocyte	6 studies	32% ± 9%	Explore
intermediate monocyte	6 studies	94% ± 8%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	100% ± 1%	Explore
CD4-positive helper T cell	5 studies	97% ± 3%	Explore
CD4-positive, alpha-beta cytotoxic T cell	5 studies	89% ± 17%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	98% ± 4%	Explore
hematopoietic precursor cell	5 studies	95% ± 6%	Explore
duct epithelial cell	5 studies	83% ± 33%	Explore
exhausted T cell	5 studies	95% ± 8%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	100% ± 0%	Explore
megakaryocyte	5 studies	91% ± 11%	Explore
OFF-bipolar cell	5 studies	87% ± 11%	Explore
ON-bipolar cell	5 studies	86% ± 11%	Explore
neuroendocrine cell	5 studies	99% ± 3%	Explore
T-helper 17 cell	5 studies	100% ± 0%	Explore
chondrocyte	5 studies	66% ± 30%	Explore
group 3 innate lymphoid cell	5 studies	100% ± 0%	Explore
retina horizontal cell	5 studies	84% ± 11%	Explore
mucus secreting cell	5 studies	81% ± 26%	Explore
Mueller cell	5 studies	77% ± 16%	Explore
double negative thymocyte	5 studies	100% ± 0%	Explore
hepatocyte	5 studies	75% ± 24%	Explore
granulocyte	5 studies	99% ± 1%	Explore
melanocyte	5 studies	86% ± 21%	Explore
deuterosomal cell	4 studies	79% ± 30%	Explore
precursor cell	4 studies	97% ± 5%	Explore
squamous epithelial cell	4 studies	55% ± 27%	Explore
pancreatic A cell	4 studies	98% ± 3%	Explore
type B pancreatic cell	4 studies	94% ± 10%	Explore
cholangiocyte	4 studies	50% ± 30%	Explore
endothelial cell of sinusoid	4 studies	55% ± 26%	Explore
glomerular endothelial cell	4 studies	93% ± 7%	Explore
kidney connecting tubule epithelial cell	4 studies	99% ± 1%	Explore
podocyte	4 studies	96% ± 4%	Explore
retinal bipolar neuron	4 studies	72% ± 21%	Explore
GABAergic amacrine cell	4 studies	76% ± 9%	Explore
glycinergic amacrine cell	4 studies	71% ± 13%	Explore
pro-B cell	4 studies	100% ± 0%	Explore
retinal pigment epithelial cell	4 studies	82% ± 20%	Explore
adventitial cell	4 studies	92% ± 12%	Explore
inflammatory macrophage	4 studies	85% ± 15%	Explore
acinar cell	4 studies	84% ± 24%	Explore
muscle cell	4 studies	58% ± 23%	Explore
germinal center B cell	4 studies	100% ± 0%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	98% ± 4%	Explore
luminal cell of prostate epithelium	4 studies	85% ± 26%	Explore
IgM plasma cell	4 studies	96% ± 5%	Explore
T-helper 1 cell	4 studies	100% ± 0%	Explore
hillock cell	3 studies	78% ± 29%	Explore
pancreatic D cell	3 studies	99% ± 1%	Explore
monocyte-derived dendritic cell	3 studies	100% ± 0%	Explore
hepatic stellate cell	3 studies	39% ± 20%	Explore
renal beta-intercalated cell	3 studies	100% ± 0%	Explore
neural crest cell	3 studies	100% ± 0%	Explore
paneth cell	3 studies	97% ± 4%	Explore
renal principal cell	3 studies	98% ± 1%	Explore
thymocyte	3 studies	100% ± 0%	Explore
extravillous trophoblast	3 studies	100% ± 0%	Explore
placental villous trophoblast	3 studies	100% ± 0%	Explore
Schwann cell	3 studies	78% ± 29%	Explore
serous secreting cell	3 studies	91% ± 7%	Explore
tissue-resident macrophage	3 studies	82% ± 25%	Explore
follicular B cell	3 studies	100% ± 0%	Explore
intraepithelial lymphocyte	3 studies	99% ± 1%	Explore
rod bipolar cell	3 studies	88% ± 6%	Explore
myoepithelial cell	3 studies	100% ± 0%	Explore
pancreatic ductal cell	3 studies	98% ± 2%	Explore
neural progenitor cell	3 studies	71% ± 14%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	100% ± 0%	Explore
keratinocyte	3 studies	99% ± 2%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	100% ± 0%	Explore
double-positive, alpha-beta thymocyte	3 studies	100% ± 0%	Explore
progenitor cell of mammary luminal epithelium	3 studies	100% ± 0%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	22 studies	94% ± 13%	Explore
lung	20 studies	87% ± 17%	Explore
brain	18 studies	50% ± 25%	Explore
intestine	13 studies	92% ± 15%	Explore
eye	11 studies	76% ± 18%	Explore
kidney	9 studies	89% ± 17%	Explore
liver	8 studies	74% ± 22%	Explore
lymph node	6 studies	99% ± 1%	Explore
heart	6 studies	35% ± 18%	Explore
pancreas	5 studies	85% ± 25%	Explore
bone marrow	5 studies	94% ± 10%	Explore
placenta	5 studies	73% ± 33%	Explore
uterus	5 studies	95% ± 9%	Explore
prostate	5 studies	72% ± 34%	Explore
adipose	4 studies	57% ± 31%	Explore
esophagus	4 studies	79% ± 23%	Explore
breast	4 studies	98% ± 3%	Explore
adrenal gland	3 studies	84% ± 19%	Explore
skin	3 studies	83% ± 22%	Explore
stomach	3 studies	79% ± 17%	Explore
thymus	3 studies	79% ± 30%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	326725.57	1445 / 1445	100%	1065.09	183 / 183
ovary	100%	562739.93	180 / 180	100%	1860.77	430 / 430
pancreas	100%	323362.05	328 / 328	100%	1276.08	178 / 178
prostate	100%	323850.98	245 / 245	100%	2042.34	502 / 502
intestine	100%	337373.88	966 / 966	100%	1699.97	525 / 527
lung	100%	282535.33	577 / 578	100%	1440.32	1152 / 1155
breast	100%	386084.92	459 / 459	100%	1730.00	1113 / 1118
thymus	100%	303805.05	653 / 653	100%	2382.10	602 / 605
stomach	100%	257756.53	359 / 359	99%	1392.38	284 / 286
uterus	100%	416547.43	170 / 170	99%	1260.14	454 / 459
bladder	100%	388452.48	21 / 21	99%	1301.11	498 / 504
kidney	100%	316271.85	89 / 89	98%	1764.43	884 / 901
skin	100%	458544.44	1809 / 1809	98%	1481.61	462 / 472
brain	97%	112719.06	2555 / 2642	100%	1543.52	703 / 705
adrenal gland	100%	302049.36	258 / 258	91%	843.05	210 / 230
liver	95%	102742.83	214 / 226	94%	781.42	380 / 406
adipose	100%	394341.25	1204 / 1204	0%	0	0 / 0
blood vessel	100%	339557.87	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	1849.04	29 / 29
spleen	100%	253255.13	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	1240.79	45 / 45
ureter	0%	0	0 / 0	100%	493.72	1 / 1
eye	0%	0	0 / 0	99%	2064.09	79 / 80
peripheral blood	94%	279677.31	871 / 929	0%	0	0 / 0
heart	76%	104938.28	653 / 861	0%	0	0 / 0
muscle	38%	39011.32	305 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_1900022	Biological process	regulation of D-erythro-sphingosine kinase activity
GO_1904714	Biological process	regulation of chaperone-mediated autophagy
GO_0071364	Biological process	cellular response to epidermal growth factor stimulus
GO_0044829	Biological process	positive regulation by host of viral genome replication
GO_0006412	Biological process	translation
GO_0006414	Biological process	translational elongation
GO_0005853	Cellular component	eukaryotic translation elongation factor 1 complex
GO_0032587	Cellular component	ruffle membrane
GO_0005730	Cellular component	nucleolus
GO_0005615	Cellular component	extracellular space
GO_0022626	Cellular component	cytosolic ribosome
GO_0005576	Cellular component	extracellular region
GO_0005886	Cellular component	plasma membrane
GO_0005840	Cellular component	ribosome
GO_0016020	Cellular component	membrane
GO_0070062	Cellular component	extracellular exosome
GO_0030864	Cellular component	cortical actin cytoskeleton
GO_0034774	Cellular component	secretory granule lumen
GO_0098574	Cellular component	cytoplasmic side of lysosomal membrane
GO_1904813	Cellular component	ficolin-1-rich granule lumen
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0060090	Molecular function	molecular adaptor activity
GO_0019900	Molecular function	kinase binding
GO_0019901	Molecular function	protein kinase binding
GO_0005525	Molecular function	GTP binding
GO_0003723	Molecular function	RNA binding
GO_0000049	Molecular function	tRNA binding
GO_0003746	Molecular function	translation elongation factor activity
GO_0005515	Molecular function	protein binding
GO_0003924	Molecular function	GTPase activity

IV. Literature review

[source]

Gene name	EEF1A1
Protein name	Elongation factor 1-alpha 1 EEF1A1 protein Elongation factor 1-alpha Elongation factor 1-alpha 1 (EF-1-alpha-1) (EC 3.6.5.-) (Elongation factor Tu) (EF-Tu) (Eukaryotic elongation factor 1 A-1) (eEF1A-1) (Leukocyte receptor cluster member 7)
Synonyms	hCG_2033271 EF1A LENG7 EEF1A
Description	FUNCTION: Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis . Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome . The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation . Also plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1 . .; FUNCTION: (Microbial infection) Required for the translation of viral proteins and viral replication during human coronavirus SARS-CoV-2 infection. . FUNCTION: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. . FUNCTION: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. . FUNCTION: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. . FUNCTION: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. . FUNCTION: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. . FUNCTION: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. . FUNCTION: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. . FUNCTION: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. .
Accessions	Q6IPS9 Q6NSH7 A0A087WV01 A6PW80 ENST00000678515.1 ENST00000610520.5 A0A087WVQ9 ENST00000331523.7 A0A7I2V5N4 ENST00000455918.2 Q6P4C9 ENST00000678703.1 ENST00000309268.11 ENST00000678702.1 A0A7I2V659 ENST00000678508.1 Q6IPN6 ENST00000676547.1 Q6P082 Q6NS35 A0A7I2V3H3 ENST00000615060.5 ENST00000676710.1 ENST00000455918 ENST00000677236.1 ENST00000356303 ENST00000615060 ENST00000356303.7 Q6IPT9 Q5JR01 ENST00000316292.13 Q504Z0 Q96EB3 P68104

EEF1A1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review