ATP6V1F report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0048388Biological processendosomal lumen acidification
GO_0007042Biological processlysosomal lumen acidification
GO_0051452Biological processintracellular pH reduction
GO_0097401Biological processsynaptic vesicle lumen acidification
GO_0007035Biological processvacuolar acidification
GO_0061795Biological processGolgi lumen acidification
GO_1902600Biological processproton transmembrane transport
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_1902495Cellular componenttransmembrane transporter complex
GO_0030672Cellular componentsynaptic vesicle membrane
GO_0070062Cellular componentextracellular exosome
GO_0033176Cellular componentproton-transporting V-type ATPase complex
GO_0000221Cellular componentvacuolar proton-transporting V-type ATPase, V1 domain
GO_0000139Cellular componentGolgi membrane
GO_0005829Cellular componentcytosol
GO_0010008Cellular componentendosome membrane
GO_0016471Cellular componentvacuolar proton-transporting V-type ATPase complex
GO_0005765Cellular componentlysosomal membrane
GO_0030665Cellular componentclathrin-coated vesicle membrane
GO_0046961Molecular functionproton-transporting ATPase activity, rotational mechanism
GO_0015078Molecular functionproton transmembrane transporter activity
GO_0042625Molecular functionATPase-coupled ion transmembrane transporter activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameATP6V1F
Protein nameV-type proton ATPase subunit F
V-type proton ATPase subunit F (V-ATPase subunit F) (V-ATPase 14 kDa subunit) (Vacuolar proton pump subunit F)
SynonymsVATF
hCG_41657
tcag7.419
ATP6S14
DescriptionFUNCTION: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons . V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). .

FUNCTION: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. .

AccessionsQ16864
ENST00000249289.5 [Q16864-1]
ENST00000492758.1 [Q16864-2]
A4D1K0