WSB1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	54 studies	54% ± 18%	Explore
fibroblast	46 studies	58% ± 17%	Explore
macrophage	45 studies	49% ± 18%	Explore
B cell	38 studies	35% ± 11%	Explore
pericyte	37 studies	47% ± 16%	Explore
smooth muscle cell	35 studies	50% ± 18%	Explore
natural killer cell	33 studies	34% ± 10%	Explore
CD8-positive, alpha-beta T cell	29 studies	27% ± 8%	Explore
T cell	28 studies	31% ± 14%	Explore
conventional dendritic cell	28 studies	45% ± 14%	Explore
mast cell	26 studies	35% ± 12%	Explore
endothelial cell of lymphatic vessel	26 studies	53% ± 15%	Explore
CD4-positive, alpha-beta T cell	26 studies	27% ± 8%	Explore
classical monocyte	25 studies	43% ± 14%	Explore
non-classical monocyte	24 studies	58% ± 14%	Explore
monocyte	23 studies	50% ± 17%	Explore
astrocyte	23 studies	54% ± 20%	Explore
dendritic cell	21 studies	44% ± 19%	Explore
regulatory T cell	21 studies	37% ± 10%	Explore
basal cell	20 studies	43% ± 22%	Explore
connective tissue cell	20 studies	48% ± 21%	Explore
epithelial cell	20 studies	51% ± 24%	Explore
memory B cell	19 studies	38% ± 9%	Explore
ciliated cell	19 studies	43% ± 18%	Explore
naive B cell	19 studies	33% ± 9%	Explore
plasmacytoid dendritic cell	18 studies	33% ± 11%	Explore
microglial cell	17 studies	57% ± 17%	Explore
CD16-negative, CD56-bright natural killer cell, human	16 studies	32% ± 12%	Explore
oligodendrocyte	16 studies	63% ± 16%	Explore
oligodendrocyte precursor cell	16 studies	59% ± 17%	Explore
mature NK T cell	16 studies	29% ± 8%	Explore
capillary endothelial cell	16 studies	47% ± 15%	Explore
myeloid cell	16 studies	49% ± 14%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	34% ± 11%	Explore
myofibroblast cell	15 studies	56% ± 16%	Explore
endothelial cell of artery	15 studies	57% ± 16%	Explore
vein endothelial cell	15 studies	53% ± 18%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	14 studies	25% ± 7%	Explore
mesothelial cell	14 studies	53% ± 15%	Explore
endothelial cell of vascular tree	14 studies	45% ± 13%	Explore
gamma-delta T cell	14 studies	32% ± 12%	Explore
mucosal invariant T cell	13 studies	28% ± 8%	Explore
type I pneumocyte	12 studies	69% ± 13%	Explore
type II pneumocyte	12 studies	76% ± 15%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	30% ± 8%	Explore
neutrophil	12 studies	41% ± 17%	Explore
secretory cell	12 studies	38% ± 18%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	27% ± 4%	Explore
plasma cell	11 studies	25% ± 8%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	27% ± 7%	Explore
GABAergic neuron	11 studies	59% ± 22%	Explore
glutamatergic neuron	11 studies	50% ± 25%	Explore
leukocyte	10 studies	42% ± 16%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	30% ± 7%	Explore
abnormal cell	10 studies	40% ± 17%	Explore
neuron	10 studies	63% ± 21%	Explore
adipocyte	10 studies	54% ± 16%	Explore
club cell	9 studies	57% ± 22%	Explore
progenitor cell	9 studies	49% ± 16%	Explore
goblet cell	9 studies	43% ± 18%	Explore
retinal cone cell	9 studies	68% ± 16%	Explore
retinal rod cell	9 studies	48% ± 17%	Explore
alveolar macrophage	8 studies	44% ± 16%	Explore
renal alpha-intercalated cell	8 studies	47% ± 10%	Explore
mononuclear phagocyte	7 studies	53% ± 15%	Explore
kidney loop of Henle epithelial cell	7 studies	40% ± 15%	Explore
kidney distal convoluted tubule epithelial cell	7 studies	62% ± 14%	Explore
amacrine cell	7 studies	37% ± 11%	Explore
glial cell	7 studies	56% ± 21%	Explore
retinal ganglion cell	7 studies	68% ± 18%	Explore
innate lymphoid cell	7 studies	33% ± 8%	Explore
T follicular helper cell	7 studies	31% ± 9%	Explore
hematopoietic precursor cell	6 studies	40% ± 21%	Explore
ionocyte	6 studies	40% ± 12%	Explore
respiratory goblet cell	6 studies	45% ± 19%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	27% ± 7%	Explore
interneuron	6 studies	64% ± 18%	Explore
precursor B cell	6 studies	40% ± 14%	Explore
retina horizontal cell	6 studies	37% ± 14%	Explore
Mueller cell	6 studies	67% ± 12%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	28% ± 6%	Explore
kidney connecting tubule epithelial cell	5 studies	82% ± 6%	Explore
enterocyte	5 studies	27% ± 6%	Explore
enteroendocrine cell	5 studies	48% ± 20%	Explore
retinal bipolar neuron	5 studies	21% ± 5%	Explore
renal principal cell	5 studies	81% ± 7%	Explore
hematopoietic stem cell	5 studies	41% ± 6%	Explore
lymphocyte	5 studies	45% ± 15%	Explore
pro-B cell	5 studies	36% ± 12%	Explore
brush cell	5 studies	43% ± 12%	Explore
retinal pigment epithelial cell	5 studies	47% ± 25%	Explore
adventitial cell	5 studies	45% ± 14%	Explore
cardiac muscle cell	5 studies	47% ± 4%	Explore
muscle cell	5 studies	44% ± 26%	Explore
intermediate monocyte	5 studies	49% ± 26%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	30% ± 10%	Explore
myoepithelial cell	5 studies	49% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	26% ± 4%	Explore
duct epithelial cell	4 studies	22% ± 9%	Explore
squamous epithelial cell	4 studies	44% ± 24%	Explore
plasmablast	4 studies	38% ± 15%	Explore
type B pancreatic cell	4 studies	39% ± 23%	Explore
exhausted T cell	4 studies	32% ± 8%	Explore
glomerular endothelial cell	4 studies	48% ± 8%	Explore
podocyte	4 studies	51% ± 8%	Explore
epithelial cell of proximal tubule	4 studies	25% ± 10%	Explore
differentiation-committed oligodendrocyte precursor	4 studies	50% ± 15%	Explore
granule cell	4 studies	35% ± 12%	Explore
Schwann cell	4 studies	79% ± 7%	Explore
immature B cell	4 studies	42% ± 10%	Explore
OFF-bipolar cell	4 studies	28% ± 12%	Explore
ON-bipolar cell	4 studies	27% ± 11%	Explore
chondrocyte	4 studies	57% ± 21%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	54% ± 14%	Explore
hepatocyte	4 studies	42% ± 24%	Explore
granulocyte	4 studies	38% ± 16%	Explore
luminal cell of prostate epithelium	4 studies	39% ± 5%	Explore
mucus secreting cell	4 studies	29% ± 5%	Explore
melanocyte	4 studies	65% ± 17%	Explore
pancreatic A cell	3 studies	47% ± 19%	Explore
cholangiocyte	3 studies	37% ± 16%	Explore
interstitial cell of Cajal	3 studies	68% ± 12%	Explore
intestinal crypt stem cell	3 studies	20% ± 2%	Explore
neural crest cell	3 studies	51% ± 17%	Explore
transit amplifying cell	3 studies	45% ± 35%	Explore
GABAergic interneuron	3 studies	48% ± 9%	Explore
extravillous trophoblast	3 studies	51% ± 11%	Explore
placental villous trophoblast	3 studies	71% ± 2%	Explore
neuroendocrine cell	3 studies	46% ± 19%	Explore
precursor cell	3 studies	53% ± 20%	Explore
endocardial cell	3 studies	63% ± 2%	Explore
tissue-resident macrophage	3 studies	57% ± 7%	Explore
GABAergic amacrine cell	3 studies	44% ± 9%	Explore
glycinergic amacrine cell	3 studies	33% ± 8%	Explore
rod bipolar cell	3 studies	30% ± 11%	Explore
inflammatory macrophage	3 studies	41% ± 8%	Explore
acinar cell	3 studies	41% ± 18%	Explore
germinal center B cell	3 studies	27% ± 2%	Explore
CD4-positive helper T cell	3 studies	32% ± 10%	Explore
endothelial cell of sinusoid	3 studies	46% ± 5%	Explore
pancreatic ductal cell	3 studies	51% ± 25%	Explore
ependymal cell	3 studies	65% ± 22%	Explore
group 3 innate lymphoid cell	3 studies	52% ± 6%	Explore
keratinocyte	3 studies	45% ± 3%	Explore
T-helper 17 cell	3 studies	25% ± 6%	Explore
T-helper 1 cell	3 studies	30% ± 7%	Explore
double negative thymocyte	3 studies	42% ± 16%	Explore
mural cell	3 studies	50% ± 11%	Explore
erythrocyte	3 studies	35% ± 19%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	21 studies	52% ± 20%	Explore
lung	20 studies	47% ± 16%	Explore
peripheral blood	17 studies	30% ± 10%	Explore
eye	12 studies	49% ± 20%	Explore
intestine	11 studies	36% ± 21%	Explore
kidney	10 studies	41% ± 9%	Explore
liver	7 studies	34% ± 17%	Explore
heart	6 studies	44% ± 12%	Explore
uterus	5 studies	46% ± 21%	Explore
adipose	5 studies	48% ± 23%	Explore
lymph node	5 studies	33% ± 8%	Explore
breast	5 studies	42% ± 7%	Explore
placenta	4 studies	51% ± 22%	Explore
bone marrow	4 studies	35% ± 14%	Explore
skin	4 studies	36% ± 10%	Explore
prostate	4 studies	29% ± 6%	Explore
pancreas	3 studies	45% ± 20%	Explore
adrenal gland	3 studies	30% ± 10%	Explore
esophagus	3 studies	52% ± 23%	Explore
stomach	3 studies	41% ± 27%	Explore
thymus	3 studies	36% ± 18%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	19455.57	21 / 21	100%	45.27	502 / 504
lung	100%	34019.38	578 / 578	100%	75.99	1150 / 1155
esophagus	100%	19162.79	1444 / 1445	99%	37.67	182 / 183
uterus	100%	29256.82	170 / 170	99%	40.48	454 / 459
breast	100%	21241.55	459 / 459	98%	31.52	1097 / 1118
intestine	100%	19953.67	966 / 966	98%	27.59	517 / 527
prostate	100%	22154.04	244 / 245	98%	33.63	491 / 502
thymus	100%	20464.32	651 / 653	97%	48.35	588 / 605
kidney	100%	22195.00	89 / 89	96%	51.53	865 / 901
stomach	99%	14884.90	356 / 359	97%	27.48	276 / 286
pancreas	97%	8426.65	318 / 328	98%	42.21	175 / 178
brain	96%	12226.16	2530 / 2642	99%	78.70	699 / 705
skin	99%	12087.00	1791 / 1809	92%	33.64	432 / 472
adrenal gland	100%	12191.71	258 / 258	90%	19.30	207 / 230
ovary	100%	27604.84	180 / 180	90%	22.52	387 / 430
liver	80%	4994.43	181 / 226	62%	14.27	251 / 406
blood vessel	100%	32582.38	1335 / 1335	0%	0	0 / 0
spleen	100%	35257.60	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	15.35	1 / 1
adipose	100%	21311.90	1203 / 1204	0%	0	0 / 0
heart	99%	13131.79	851 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	28.89	44 / 45
muscle	91%	6279.76	728 / 803	0%	0	0 / 0
lymph node	0%	0	0 / 0	90%	38.89	26 / 29
peripheral blood	83%	13349.14	771 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	80%	40.14	64 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

IV. Literature review

[source]

Gene name	WSB1
Protein name	WD repeat and SOCS box-containing protein 1 (WSB-1) (SOCS box-containing WD protein SWiP-1) WD repeat and SOCS box containing 1 (cDNA FLJ59301, highly similar to WD repeat and SOCS box-containing protein 1) WD repeat and SOCS box containing 1 WD repeat and SOCS box containing 1 (cDNA FLJ58059, highly similar to WD repeat and SOCS box-containing protein 1) WD repeat and SOCS box-containing protein 1
Synonyms	SWIP1
Description	FUNCTION: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes type II iodothyronine deiodinase/DIO2. Confers constitutive instability to HIPK2 through proteasomal degradation. .
Accessions	ENST00000582208.1 J3QLM8 ENST00000262394.7 [Q9Y6I7-1] Q9Y6I7 J3KSQ3 J3KT03 B4DTL1 ENST00000427287.6 ENST00000584114.1 ENST00000583193.5 ENST00000348811.6 [Q9Y6I7-2] ENST00000581185.5 ENST00000583742.1 A0JLP1 J3KS88 J3KRG6 B4DGB8 ENST00000579733.5 J3KTB3 ENST00000581440.5

GO_0035556	Biological process	intracellular signal transduction
GO_0044314	Biological process	protein K27-linked ubiquitination
GO_0000209	Biological process	protein polyubiquitination
GO_0140454	Biological process	protein aggregate center assembly
GO_0008150	Biological process	biological_process
GO_0005829	Cellular component	cytosol
GO_0061630	Molecular function	ubiquitin protein ligase activity
GO_0005515	Molecular function	protein binding

WSB1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review