UBE2L3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	35 studies	31% ± 13%	Explore
natural killer cell	34 studies	33% ± 10%	Explore
B cell	31 studies	27% ± 11%	Explore
CD8-positive, alpha-beta T cell	31 studies	34% ± 15%	Explore
macrophage	30 studies	31% ± 12%	Explore
fibroblast	28 studies	27% ± 12%	Explore
CD4-positive, alpha-beta T cell	27 studies	32% ± 14%	Explore
T cell	26 studies	32% ± 11%	Explore
conventional dendritic cell	25 studies	40% ± 15%	Explore
classical monocyte	23 studies	31% ± 14%	Explore
non-classical monocyte	22 studies	33% ± 14%	Explore
regulatory T cell	22 studies	32% ± 11%	Explore
pericyte	21 studies	25% ± 9%	Explore
dendritic cell	19 studies	37% ± 22%	Explore
monocyte	19 studies	30% ± 9%	Explore
plasmacytoid dendritic cell	19 studies	37% ± 11%	Explore
epithelial cell	18 studies	35% ± 21%	Explore
smooth muscle cell	17 studies	26% ± 6%	Explore
memory B cell	17 studies	24% ± 7%	Explore
gamma-delta T cell	17 studies	33% ± 13%	Explore
endothelial cell of lymphatic vessel	16 studies	32% ± 12%	Explore
ciliated cell	16 studies	36% ± 19%	Explore
naive B cell	16 studies	22% ± 5%	Explore
basal cell	15 studies	34% ± 18%	Explore
mature NK T cell	15 studies	31% ± 7%	Explore
mast cell	14 studies	23% ± 7%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	34% ± 9%	Explore
plasma cell	13 studies	37% ± 13%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	13 studies	25% ± 6%	Explore
connective tissue cell	13 studies	28% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	33% ± 13%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	31% ± 8%	Explore
capillary endothelial cell	12 studies	24% ± 6%	Explore
myeloid cell	12 studies	36% ± 12%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	31% ± 9%	Explore
vein endothelial cell	11 studies	25% ± 8%	Explore
plasmablast	10 studies	48% ± 22%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	32% ± 12%	Explore
abnormal cell	10 studies	29% ± 8%	Explore
endothelial cell of artery	10 studies	25% ± 8%	Explore
mucosal invariant T cell	10 studies	29% ± 4%	Explore
endothelial cell of vascular tree	10 studies	26% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	32% ± 11%	Explore
myofibroblast cell	9 studies	26% ± 5%	Explore
type I pneumocyte	8 studies	27% ± 12%	Explore
platelet	8 studies	22% ± 5%	Explore
progenitor cell	8 studies	25% ± 6%	Explore
goblet cell	8 studies	27% ± 12%	Explore
alveolar macrophage	7 studies	25% ± 6%	Explore
secretory cell	7 studies	34% ± 21%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	43% ± 19%	Explore
neuron	7 studies	29% ± 15%	Explore
precursor B cell	7 studies	35% ± 14%	Explore
astrocyte	7 studies	28% ± 10%	Explore
T follicular helper cell	7 studies	27% ± 4%	Explore
hematopoietic precursor cell	6 studies	45% ± 24%	Explore
club cell	6 studies	31% ± 10%	Explore
leukocyte	6 studies	34% ± 11%	Explore
mononuclear phagocyte	6 studies	33% ± 16%	Explore
epithelial cell of proximal tubule	6 studies	23% ± 3%	Explore
enterocyte	6 studies	26% ± 5%	Explore
glutamatergic neuron	6 studies	35% ± 20%	Explore
innate lymphoid cell	6 studies	30% ± 7%	Explore
type II pneumocyte	6 studies	27% ± 16%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	37% ± 17%	Explore
oligodendrocyte precursor cell	6 studies	27% ± 9%	Explore
kidney loop of Henle epithelial cell	5 studies	21% ± 4%	Explore
enteroendocrine cell	5 studies	37% ± 15%	Explore
transit amplifying cell	5 studies	20% ± 0%	Explore
hematopoietic stem cell	5 studies	30% ± 10%	Explore
lymphocyte	5 studies	32% ± 13%	Explore
pro-B cell	5 studies	36% ± 7%	Explore
immature B cell	5 studies	29% ± 15%	Explore
oligodendrocyte	5 studies	23% ± 5%	Explore
respiratory goblet cell	4 studies	32% ± 22%	Explore
exhausted T cell	4 studies	48% ± 15%	Explore
mesothelial cell	4 studies	33% ± 21%	Explore
retinal ganglion cell	4 studies	51% ± 27%	Explore
erythroblast	4 studies	46% ± 24%	Explore
megakaryocyte	4 studies	36% ± 9%	Explore
brush cell	4 studies	27% ± 10%	Explore
microglial cell	4 studies	27% ± 7%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	50% ± 9%	Explore
intermediate monocyte	4 studies	43% ± 20%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	34% ± 8%	Explore
GABAergic neuron	4 studies	36% ± 14%	Explore
erythrocyte	4 studies	35% ± 20%	Explore
T-helper 17 cell	4 studies	41% ± 22%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	31% ± 8%	Explore
deuterosomal cell	3 studies	28% ± 1%	Explore
duct epithelial cell	3 studies	20% ± 1%	Explore
ionocyte	3 studies	25% ± 5%	Explore
pancreatic A cell	3 studies	66% ± 10%	Explore
type B pancreatic cell	3 studies	45% ± 19%	Explore
glomerular endothelial cell	3 studies	23% ± 5%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	28% ± 5%	Explore
intestinal crypt stem cell	3 studies	25% ± 10%	Explore
neural crest cell	3 studies	31% ± 4%	Explore
extravillous trophoblast	3 studies	49% ± 16%	Explore
placental villous trophoblast	3 studies	59% ± 12%	Explore
neuroendocrine cell	3 studies	35% ± 9%	Explore
retinal cone cell	3 studies	32% ± 17%	Explore
intraepithelial lymphocyte	3 studies	35% ± 11%	Explore
Mueller cell	3 studies	18% ± 1%	Explore
germinal center B cell	3 studies	37% ± 2%	Explore
granulocyte	3 studies	28% ± 8%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	45% ± 23%	Explore
neutrophil	3 studies	18% ± 3%	Explore
group 3 innate lymphoid cell	3 studies	33% ± 18%	Explore
keratinocyte	3 studies	21% ± 2%	Explore
interneuron	3 studies	33% ± 19%	Explore
T-helper 1 cell	3 studies	42% ± 11%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	27% ± 8%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	27% ± 9%	Explore
double negative thymocyte	3 studies	49% ± 15%	Explore
hepatocyte	3 studies	49% ± 24%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	17 studies	33% ± 10%	Explore
lung	16 studies	33% ± 15%	Explore
intestine	10 studies	25% ± 11%	Explore
kidney	9 studies	25% ± 6%	Explore
brain	9 studies	29% ± 11%	Explore
eye	6 studies	21% ± 10%	Explore
bone marrow	5 studies	27% ± 7%	Explore
lymph node	5 studies	26% ± 5%	Explore
liver	5 studies	38% ± 23%	Explore
uterus	4 studies	33% ± 13%	Explore
breast	4 studies	25% ± 3%	Explore
pancreas	3 studies	55% ± 14%	Explore
placenta	3 studies	48% ± 16%	Explore
thymus	3 studies	48% ± 22%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	4711.76	21 / 21	100%	93.89	504 / 504
brain	100%	5848.99	2642 / 2642	100%	97.80	705 / 705
esophagus	100%	5495.13	1445 / 1445	100%	86.13	183 / 183
intestine	100%	5261.39	966 / 966	100%	81.33	527 / 527
kidney	100%	4309.52	89 / 89	100%	70.92	901 / 901
liver	100%	2563.09	226 / 226	100%	51.86	406 / 406
ovary	100%	3388.39	180 / 180	100%	85.82	430 / 430
prostate	100%	5045.63	245 / 245	100%	95.40	502 / 502
stomach	100%	3803.66	359 / 359	100%	85.62	286 / 286
uterus	100%	4309.70	170 / 170	100%	98.76	459 / 459
skin	100%	4896.42	1808 / 1809	100%	102.20	472 / 472
lung	100%	4130.14	578 / 578	100%	92.36	1154 / 1155
breast	100%	4354.44	459 / 459	100%	92.40	1117 / 1118
thymus	100%	3971.55	652 / 653	100%	77.97	605 / 605
pancreas	99%	1940.83	325 / 328	100%	76.19	178 / 178
adrenal gland	100%	5439.44	258 / 258	99%	58.38	227 / 230
adipose	100%	4699.36	1204 / 1204	0%	0	0 / 0
blood vessel	100%	5380.97	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	75.19	80 / 80
lymph node	0%	0	0 / 0	100%	107.33	29 / 29
muscle	100%	4565.47	803 / 803	0%	0	0 / 0
spleen	100%	4624.35	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	97.30	45 / 45
ureter	0%	0	0 / 0	100%	111.77	1 / 1
heart	99%	3572.94	856 / 861	0%	0	0 / 0
peripheral blood	97%	3786.87	904 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0016567	Biological process	protein ubiquitination
GO_0070979	Biological process	protein K11-linked ubiquitination
GO_0008283	Biological process	cell population proliferation
GO_0000209	Biological process	protein polyubiquitination
GO_0051443	Biological process	positive regulation of ubiquitin-protein transferase activity
GO_0071383	Biological process	cellular response to steroid hormone stimulus
GO_0006511	Biological process	ubiquitin-dependent protein catabolic process
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0036211	Biological process	protein modification process
GO_0006355	Biological process	regulation of DNA-templated transcription
GO_0031398	Biological process	positive regulation of protein ubiquitination
GO_0071385	Biological process	cellular response to glucocorticoid stimulus
GO_1903955	Biological process	positive regulation of protein targeting to mitochondrion
GO_0044770	Biological process	cell cycle phase transition
GO_0000151	Cellular component	ubiquitin ligase complex
GO_0098793	Cellular component	presynapse
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0019899	Molecular function	enzyme binding
GO_0031625	Molecular function	ubiquitin protein ligase binding
GO_0005524	Molecular function	ATP binding
GO_0003723	Molecular function	RNA binding
GO_0004842	Molecular function	ubiquitin-protein transferase activity
GO_0061631	Molecular function	ubiquitin conjugating enzyme activity
GO_0003713	Molecular function	transcription coactivator activity
GO_0097027	Molecular function	ubiquitin-protein transferase activator activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	UBE2L3
Protein name	Ubiquitin conjugating enzyme E2 L3 Ubiquitin-conjugating enzyme E2 L3 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme L3) (L-UBC) (UbcH7) (Ubiquitin carrier protein L3) (Ubiquitin-conjugating enzyme E2-F1) (Ubiquitin-protein ligase L3)
Synonyms	UBCE7 UBCH7
Description	FUNCTION: Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PRKN, RNF31 and ARIH1, that function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down-regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis. .
Accessions	ENST00000696046.1 ENST00000458578.6 [P68036-3] A0A8Q3WL22 P68036 ENST00000342192.9 [P68036-1] ENST00000545681.2 [P68036-2]

UBE2L3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review