UBC report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0019941Biological processmodification-dependent protein catabolic process
GO_0016567Biological processprotein ubiquitination
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005741Cellular componentmitochondrial outer membrane
GO_0030666Cellular componentendocytic vesicle membrane
GO_0005615Cellular componentextracellular space
GO_0010008Cellular componentendosome membrane
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0031982Cellular componentvesicle
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0031386Molecular functionprotein tag activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0005515Molecular functionprotein binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameUBC
Protein nameUBC protein
UBC protein (Ubiquitin C)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Ubiquitin C
Ubiquitin C splice variant
SynonymsUbC
hCG_1744180
DescriptionFUNCTION: [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. .

AccessionsF5H265
F5H6Q2
ENST00000535859.1
F5H388
Q96C32
A8CGI2
ENST00000339647.6
ENST00000546271.1
ENST00000542416.1
Q5UGI3
F5GXK7
ENST00000536769.1
F5H747
ENST00000538617.5
ENST00000540351.1
L8B4I8
ENST00000541272.1
ENST00000540700.1
F5H2Z3
P0CG48
ENST00000535131.1
F5GZ39
Q96H31
F5GYU3
ENST00000541645.1
Q5PY61