TRA2B | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	44 studies	40% ± 16%	Explore
fibroblast	41 studies	34% ± 14%	Explore
B cell	37 studies	46% ± 14%	Explore
natural killer cell	37 studies	40% ± 13%	Explore
macrophage	35 studies	37% ± 15%	Explore
T cell	34 studies	36% ± 14%	Explore
pericyte	33 studies	37% ± 15%	Explore
CD8-positive, alpha-beta T cell	33 studies	38% ± 12%	Explore
CD4-positive, alpha-beta T cell	31 studies	40% ± 13%	Explore
smooth muscle cell	29 studies	33% ± 13%	Explore
conventional dendritic cell	28 studies	42% ± 18%	Explore
dendritic cell	24 studies	39% ± 20%	Explore
regulatory T cell	24 studies	37% ± 10%	Explore
non-classical monocyte	23 studies	39% ± 15%	Explore
classical monocyte	23 studies	39% ± 14%	Explore
mast cell	22 studies	37% ± 16%	Explore
basal cell	22 studies	32% ± 15%	Explore
monocyte	21 studies	38% ± 16%	Explore
plasmacytoid dendritic cell	21 studies	44% ± 15%	Explore
memory B cell	20 studies	42% ± 11%	Explore
naive B cell	19 studies	40% ± 10%	Explore
mature NK T cell	19 studies	33% ± 10%	Explore
epithelial cell	19 studies	37% ± 23%	Explore
endothelial cell of lymphatic vessel	18 studies	25% ± 10%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	35% ± 13%	Explore
gamma-delta T cell	17 studies	39% ± 14%	Explore
myeloid cell	17 studies	38% ± 20%	Explore
plasma cell	16 studies	34% ± 13%	Explore
connective tissue cell	16 studies	40% ± 15%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	40% ± 13%	Explore
myofibroblast cell	15 studies	38% ± 16%	Explore
capillary endothelial cell	14 studies	30% ± 11%	Explore
microglial cell	14 studies	35% ± 16%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	38% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	13 studies	43% ± 12%	Explore
vein endothelial cell	13 studies	31% ± 13%	Explore
mucosal invariant T cell	13 studies	33% ± 8%	Explore
endothelial cell of vascular tree	13 studies	36% ± 11%	Explore
ciliated cell	13 studies	32% ± 17%	Explore
astrocyte	13 studies	31% ± 12%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	39% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	40% ± 13%	Explore
endothelial cell of artery	12 studies	27% ± 8%	Explore
type II pneumocyte	11 studies	30% ± 13%	Explore
secretory cell	11 studies	26% ± 9%	Explore
leukocyte	11 studies	43% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell	11 studies	38% ± 14%	Explore
progenitor cell	11 studies	40% ± 19%	Explore
plasmablast	10 studies	50% ± 25%	Explore
mesothelial cell	10 studies	37% ± 18%	Explore
oligodendrocyte precursor cell	10 studies	36% ± 14%	Explore
innate lymphoid cell	9 studies	46% ± 15%	Explore
abnormal cell	9 studies	37% ± 13%	Explore
alveolar macrophage	8 studies	26% ± 6%	Explore
type I pneumocyte	8 studies	34% ± 13%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	37% ± 11%	Explore
neuron	8 studies	35% ± 17%	Explore
goblet cell	8 studies	35% ± 17%	Explore
retinal rod cell	7 studies	30% ± 11%	Explore
precursor B cell	7 studies	58% ± 20%	Explore
club cell	7 studies	32% ± 14%	Explore
T follicular helper cell	7 studies	42% ± 14%	Explore
GABAergic neuron	7 studies	33% ± 15%	Explore
oligodendrocyte	7 studies	26% ± 8%	Explore
hematopoietic precursor cell	6 studies	58% ± 26%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	37% ± 16%	Explore
mononuclear phagocyte	6 studies	43% ± 17%	Explore
transit amplifying cell	6 studies	39% ± 19%	Explore
glutamatergic neuron	6 studies	39% ± 20%	Explore
hematopoietic stem cell	6 studies	43% ± 10%	Explore
immature B cell	6 studies	59% ± 10%	Explore
adipocyte	6 studies	25% ± 5%	Explore
erythrocyte	6 studies	35% ± 20%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	41% ± 13%	Explore
kidney loop of Henle epithelial cell	5 studies	20% ± 6%	Explore
enteroendocrine cell	5 studies	34% ± 16%	Explore
amacrine cell	5 studies	36% ± 13%	Explore
lymphocyte	5 studies	44% ± 17%	Explore
pro-B cell	5 studies	52% ± 16%	Explore
retinal cone cell	5 studies	31% ± 17%	Explore
granulocyte	5 studies	34% ± 11%	Explore
interneuron	5 studies	34% ± 19%	Explore
pancreatic A cell	4 studies	42% ± 10%	Explore
exhausted T cell	4 studies	44% ± 14%	Explore
glomerular endothelial cell	4 studies	52% ± 20%	Explore
intestinal crypt stem cell	4 studies	26% ± 7%	Explore
glial cell	4 studies	36% ± 22%	Explore
erythroblast	4 studies	57% ± 25%	Explore
brush cell	4 studies	30% ± 7%	Explore
retina horizontal cell	4 studies	28% ± 10%	Explore
retinal pigment epithelial cell	4 studies	46% ± 14%	Explore
Mueller cell	4 studies	39% ± 2%	Explore
muscle cell	4 studies	39% ± 15%	Explore
intermediate monocyte	4 studies	46% ± 22%	Explore
CD4-positive helper T cell	4 studies	34% ± 19%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	45% ± 8%	Explore
hepatocyte	4 studies	44% ± 27%	Explore
luminal cell of prostate epithelium	4 studies	23% ± 6%	Explore
group 3 innate lymphoid cell	4 studies	59% ± 12%	Explore
T-helper 17 cell	4 studies	39% ± 14%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	30% ± 6%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	38% ± 10%	Explore
double negative thymocyte	4 studies	48% ± 18%	Explore
ionocyte	3 studies	26% ± 8%	Explore
precursor cell	3 studies	50% ± 18%	Explore
platelet	3 studies	21% ± 4%	Explore
pancreatic D cell	3 studies	34% ± 19%	Explore
type B pancreatic cell	3 studies	39% ± 7%	Explore
monocyte-derived dendritic cell	3 studies	36% ± 18%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	49% ± 23%	Explore
enterocyte	3 studies	17% ± 1%	Explore
neural crest cell	3 studies	53% ± 13%	Explore
retinal bipolar neuron	3 studies	34% ± 10%	Explore
placental villous trophoblast	3 studies	30% ± 11%	Explore
cardiac muscle cell	3 studies	18% ± 1%	Explore
tissue-resident macrophage	3 studies	53% ± 18%	Explore
rod bipolar cell	3 studies	24% ± 3%	Explore
inflammatory macrophage	3 studies	36% ± 11%	Explore
respiratory goblet cell	3 studies	31% ± 10%	Explore
acinar cell	3 studies	36% ± 11%	Explore
germinal center B cell	3 studies	46% ± 4%	Explore
pancreatic ductal cell	3 studies	47% ± 15%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	68% ± 25%	Explore
adventitial cell	3 studies	31% ± 10%	Explore
melanocyte	3 studies	46% ± 16%	Explore
keratinocyte	3 studies	35% ± 12%	Explore
T-helper 1 cell	3 studies	48% ± 10%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	39% ± 6%	Explore
myoepithelial cell	3 studies	38% ± 5%	Explore
mural cell	3 studies	31% ± 13%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	19 studies	34% ± 14%	Explore
peripheral blood	17 studies	41% ± 14%	Explore
brain	15 studies	30% ± 15%	Explore
intestine	10 studies	35% ± 16%	Explore
kidney	9 studies	29% ± 14%	Explore
eye	8 studies	37% ± 13%	Explore
liver	7 studies	35% ± 20%	Explore
bone marrow	5 studies	32% ± 17%	Explore
uterus	5 studies	40% ± 16%	Explore
adipose	5 studies	23% ± 5%	Explore
lymph node	5 studies	41% ± 12%	Explore
pancreas	4 studies	37% ± 14%	Explore
breast	4 studies	33% ± 6%	Explore
placenta	3 studies	29% ± 9%	Explore
heart	3 studies	20% ± 3%	Explore
adrenal gland	3 studies	32% ± 12%	Explore
thymus	3 studies	55% ± 24%	Explore
prostate	3 studies	27% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	6881.90	459 / 459	100%	37.77	1118 / 1118
esophagus	100%	5723.94	1445 / 1445	100%	38.68	183 / 183
intestine	100%	6040.80	966 / 966	100%	33.03	527 / 527
lung	100%	6498.08	578 / 578	100%	39.24	1155 / 1155
ovary	100%	7366.18	180 / 180	100%	36.75	430 / 430
stomach	100%	4567.89	359 / 359	100%	31.66	286 / 286
uterus	100%	7194.98	170 / 170	100%	49.89	459 / 459
brain	100%	4018.14	2637 / 2642	100%	31.62	705 / 705
bladder	100%	6126.14	21 / 21	100%	33.46	503 / 504
thymus	100%	7282.70	653 / 653	100%	34.29	603 / 605
prostate	100%	6195.50	245 / 245	100%	29.83	500 / 502
skin	100%	6982.14	1809 / 1809	99%	34.75	469 / 472
pancreas	100%	3030.66	328 / 328	99%	26.51	176 / 178
kidney	100%	4716.20	89 / 89	98%	21.27	881 / 901
adrenal gland	100%	6577.52	258 / 258	97%	19.14	224 / 230
liver	100%	3334.65	226 / 226	97%	15.78	395 / 406
adipose	100%	7351.60	1204 / 1204	0%	0	0 / 0
blood vessel	100%	5964.04	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	47.86	29 / 29
spleen	100%	7209.66	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	52.58	45 / 45
ureter	0%	0	0 / 0	100%	8.67	1 / 1
muscle	100%	4070.80	802 / 803	0%	0	0 / 0
heart	99%	3256.99	850 / 861	0%	0	0 / 0
peripheral blood	94%	5054.40	874 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	94%	19.37	75 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0071333	Biological process	cellular response to glucose stimulus
GO_0048026	Biological process	positive regulation of mRNA splicing, via spliceosome
GO_0000381	Biological process	regulation of alternative mRNA splicing, via spliceosome
GO_0000398	Biological process	mRNA splicing, via spliceosome
GO_0021796	Biological process	cerebral cortex regionalization
GO_0043484	Biological process	regulation of RNA splicing
GO_0000375	Biological process	RNA splicing, via transesterification reactions
GO_1990403	Biological process	embryonic brain development
GO_0005681	Cellular component	spliceosomal complex
GO_0032991	Cellular component	protein-containing complex
GO_0005654	Cellular component	nucleoplasm
GO_0005637	Cellular component	nuclear inner membrane
GO_0005634	Cellular component	nucleus
GO_0019904	Molecular function	protein domain specific binding
GO_0042802	Molecular function	identical protein binding
GO_0003729	Molecular function	mRNA binding
GO_0003723	Molecular function	RNA binding
GO_0036002	Molecular function	pre-mRNA binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	TRA2B
Protein name	Transformer 2 beta homolog Transformer-2 protein homolog beta (TRA-2 beta) (TRA2-beta) (hTRA2-beta) (Splicing factor, arginine/serine-rich 10) (Transformer-2 protein homolog B)
Synonyms	SFRS10
Description	FUNCTION: Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA. .
Accessions	ENST00000456380.5 [P62995-2] ENST00000259043.11 H7BXF3 H7C2L4 ENST00000453386.7 [P62995-1] ENST00000382191.4 [P62995-3] P62995 ENST00000414862.5

TRA2B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review