SUMO2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032436Biological processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0016925Biological processprotein sumoylation
GO_0005654Cellular componentnucleoplasm
GO_0016605Cellular componentPML body
GO_0005634Cellular componentnucleus
GO_0031386Molecular functionprotein tag activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0005515Molecular functionprotein binding
GO_0044389Molecular functionubiquitin-like protein ligase binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameSUMO2
Protein nameSmall ubiquitin-related modifier 2 (SUMO-2) (HSMT3) (SMT3 homolog 2) (SUMO-3) (Sentrin-2) (Ubiquitin-like protein SMT3B) (Smt3B)
Small ubiquitin like modifier 2
SynonymsSMT3H2
SMT3B
DescriptionFUNCTION: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451 . This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins . Plays a role in the regulation of sumoylation status of SETX . .

AccessionsJ3KRH1
ENST00000420826.7 [P61956-1]
ENST00000578238.2
P61956
ENST00000314523.7 [P61956-2]