SF3B5 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	36 studies	39% ± 11%	Explore
B cell	35 studies	32% ± 12%	Explore
fibroblast	33 studies	36% ± 15%	Explore
CD8-positive, alpha-beta T cell	31 studies	40% ± 15%	Explore
endothelial cell	29 studies	34% ± 15%	Explore
CD4-positive, alpha-beta T cell	29 studies	39% ± 13%	Explore
T cell	28 studies	37% ± 10%	Explore
macrophage	28 studies	35% ± 12%	Explore
conventional dendritic cell	26 studies	41% ± 15%	Explore
classical monocyte	25 studies	41% ± 15%	Explore
non-classical monocyte	23 studies	42% ± 16%	Explore
pericyte	22 studies	35% ± 14%	Explore
regulatory T cell	22 studies	40% ± 9%	Explore
smooth muscle cell	21 studies	35% ± 13%	Explore
plasmacytoid dendritic cell	20 studies	46% ± 14%	Explore
memory B cell	19 studies	32% ± 9%	Explore
plasma cell	19 studies	45% ± 16%	Explore
dendritic cell	18 studies	42% ± 22%	Explore
monocyte	18 studies	39% ± 10%	Explore
mature NK T cell	18 studies	37% ± 10%	Explore
epithelial cell	18 studies	42% ± 21%	Explore
basal cell	17 studies	35% ± 16%	Explore
naive B cell	17 studies	29% ± 8%	Explore
gamma-delta T cell	17 studies	42% ± 13%	Explore
endothelial cell of lymphatic vessel	16 studies	37% ± 12%	Explore
ciliated cell	16 studies	40% ± 19%	Explore
connective tissue cell	16 studies	41% ± 15%	Explore
mast cell	15 studies	34% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	40% ± 13%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	38% ± 14%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	14 studies	33% ± 10%	Explore
mucosal invariant T cell	13 studies	36% ± 12%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	38% ± 12%	Explore
myofibroblast cell	13 studies	39% ± 14%	Explore
capillary endothelial cell	12 studies	25% ± 10%	Explore
plasmablast	11 studies	54% ± 20%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	35% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	41% ± 14%	Explore
goblet cell	11 studies	38% ± 18%	Explore
vein endothelial cell	11 studies	30% ± 11%	Explore
progenitor cell	10 studies	49% ± 17%	Explore
abnormal cell	10 studies	37% ± 17%	Explore
endothelial cell of artery	10 studies	26% ± 10%	Explore
endothelial cell of vascular tree	10 studies	30% ± 7%	Explore
myeloid cell	10 studies	39% ± 13%	Explore
secretory cell	9 studies	32% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	41% ± 16%	Explore
type I pneumocyte	8 studies	28% ± 14%	Explore
leukocyte	8 studies	37% ± 13%	Explore
T follicular helper cell	8 studies	39% ± 7%	Explore
type II pneumocyte	7 studies	45% ± 21%	Explore
club cell	7 studies	31% ± 12%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	46% ± 14%	Explore
epithelial cell of proximal tubule	7 studies	39% ± 16%	Explore
mesothelial cell	7 studies	49% ± 19%	Explore
hematopoietic precursor cell	6 studies	50% ± 28%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	46% ± 14%	Explore
kidney loop of Henle epithelial cell	6 studies	32% ± 9%	Explore
renal alpha-intercalated cell	6 studies	44% ± 10%	Explore
enterocyte	6 studies	30% ± 7%	Explore
IgA plasma cell	6 studies	25% ± 12%	Explore
transit amplifying cell	6 studies	39% ± 18%	Explore
hematopoietic stem cell	6 studies	43% ± 13%	Explore
innate lymphoid cell	6 studies	38% ± 7%	Explore
erythrocyte	6 studies	40% ± 21%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	42% ± 16%	Explore
alveolar macrophage	5 studies	30% ± 6%	Explore
CD4-positive helper T cell	5 studies	30% ± 14%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	32% ± 10%	Explore
ionocyte	5 studies	26% ± 7%	Explore
mononuclear phagocyte	5 studies	46% ± 18%	Explore
enteroendocrine cell	5 studies	47% ± 19%	Explore
intestinal crypt stem cell	5 studies	39% ± 14%	Explore
erythroblast	5 studies	41% ± 24%	Explore
precursor B cell	5 studies	40% ± 10%	Explore
pro-B cell	5 studies	34% ± 10%	Explore
brush cell	5 studies	25% ± 12%	Explore
neuron	5 studies	47% ± 18%	Explore
granulocyte	5 studies	32% ± 13%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	29% ± 12%	Explore
respiratory goblet cell	4 studies	35% ± 27%	Explore
pancreatic A cell	4 studies	60% ± 18%	Explore
type B pancreatic cell	4 studies	64% ± 17%	Explore
exhausted T cell	4 studies	54% ± 10%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	51% ± 14%	Explore
IgG plasma cell	4 studies	25% ± 12%	Explore
immature B cell	4 studies	44% ± 21%	Explore
adventitial cell	4 studies	22% ± 6%	Explore
neutrophil	4 studies	20% ± 2%	Explore
intermediate monocyte	4 studies	55% ± 19%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	46% ± 5%	Explore
T-helper 17 cell	4 studies	45% ± 17%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	38% ± 17%	Explore
deuterosomal cell	3 studies	35% ± 1%	Explore
duct epithelial cell	3 studies	28% ± 2%	Explore
precursor cell	3 studies	52% ± 19%	Explore
pancreatic D cell	3 studies	61% ± 18%	Explore
neural crest cell	3 studies	53% ± 7%	Explore
placental villous trophoblast	3 studies	33% ± 18%	Explore
lymphocyte	3 studies	47% ± 13%	Explore
megakaryocyte	3 studies	30% ± 7%	Explore
neuroendocrine cell	3 studies	45% ± 14%	Explore
astrocyte	3 studies	29% ± 17%	Explore
retinal cone cell	3 studies	42% ± 17%	Explore
retinal rod cell	3 studies	26% ± 9%	Explore
mucus secreting cell	3 studies	34% ± 7%	Explore
serous secreting cell	3 studies	32% ± 12%	Explore
intraepithelial lymphocyte	3 studies	40% ± 9%	Explore
Mueller cell	3 studies	29% ± 9%	Explore
acinar cell	3 studies	27% ± 7%	Explore
muscle cell	3 studies	34% ± 20%	Explore
germinal center B cell	3 studies	37% ± 1%	Explore
myoepithelial cell	3 studies	41% ± 9%	Explore
inflammatory macrophage	3 studies	29% ± 7%	Explore
IgM plasma cell	3 studies	32% ± 11%	Explore
pancreatic ductal cell	3 studies	59% ± 4%	Explore
granulocyte monocyte progenitor cell	3 studies	52% ± 27%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	53% ± 28%	Explore
glial cell	3 studies	42% ± 25%	Explore
hepatocyte	3 studies	47% ± 31%	Explore
group 3 innate lymphoid cell	3 studies	49% ± 10%	Explore
keratinocyte	3 studies	42% ± 10%	Explore
T-helper 1 cell	3 studies	54% ± 6%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	35% ± 11%	Explore
double negative thymocyte	3 studies	56% ± 16%	Explore
progenitor cell of mammary luminal epithelium	3 studies	36% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	19 studies	40% ± 13%	Explore
lung	17 studies	36% ± 14%	Explore
intestine	12 studies	34% ± 16%	Explore
kidney	8 studies	36% ± 8%	Explore
eye	6 studies	25% ± 11%	Explore
pancreas	5 studies	50% ± 23%	Explore
bone marrow	5 studies	29% ± 8%	Explore
brain	5 studies	23% ± 7%	Explore
liver	5 studies	42% ± 20%	Explore
lymph node	5 studies	37% ± 8%	Explore
placenta	4 studies	30% ± 14%	Explore
uterus	4 studies	45% ± 18%	Explore
breast	4 studies	35% ± 5%	Explore
adrenal gland	3 studies	29% ± 4%	Explore
esophagus	3 studies	47% ± 27%	Explore
thymus	3 studies	57% ± 28%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2809.61	1445 / 1445	100%	260.94	183 / 183
liver	100%	2542.56	226 / 226	100%	300.61	406 / 406
ovary	100%	2415.39	180 / 180	100%	338.76	430 / 430
thymus	100%	2542.03	653 / 653	100%	377.12	604 / 605
skin	100%	3404.59	1809 / 1809	100%	341.18	471 / 472
brain	100%	1866.17	2636 / 2642	100%	333.28	704 / 705
uterus	100%	2447.90	170 / 170	100%	440.62	457 / 459
pancreas	100%	2054.41	328 / 328	99%	306.96	177 / 178
intestine	100%	2806.11	966 / 966	99%	436.79	524 / 527
stomach	100%	2255.28	359 / 359	99%	363.71	284 / 286
prostate	100%	2762.45	245 / 245	99%	437.09	498 / 502
adrenal gland	100%	4246.81	258 / 258	99%	307.92	228 / 230
kidney	100%	3553.37	89 / 89	99%	282.41	893 / 901
lung	100%	2538.29	577 / 578	99%	335.26	1143 / 1155
bladder	100%	2480.24	21 / 21	99%	406.10	497 / 504
breast	100%	2736.61	459 / 459	98%	339.21	1101 / 1118
adipose	100%	2669.64	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	394.61	80 / 80
lymph node	0%	0	0 / 0	100%	664.70	29 / 29
muscle	100%	2342.43	803 / 803	0%	0	0 / 0
spleen	100%	2981.56	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	420.37	45 / 45
ureter	0%	0	0 / 0	100%	208.57	1 / 1
blood vessel	100%	2439.94	1333 / 1335	0%	0	0 / 0
peripheral blood	99%	2668.12	920 / 929	0%	0	0 / 0
heart	99%	2267.78	851 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0000398	Biological process	mRNA splicing, via spliceosome
GO_0006282	Biological process	regulation of DNA repair
GO_0043484	Biological process	regulation of RNA splicing
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_1903241	Biological process	U2-type prespliceosome assembly
GO_0005686	Cellular component	U2 snRNP
GO_0000124	Cellular component	SAGA complex
GO_0005684	Cellular component	U2-type spliceosomal complex
GO_0071011	Cellular component	precatalytic spliceosome
GO_0005654	Cellular component	nucleoplasm
GO_0005681	Cellular component	spliceosomal complex
GO_0071005	Cellular component	U2-type precatalytic spliceosome
GO_0005689	Cellular component	U12-type spliceosomal complex
GO_0005634	Cellular component	nucleus
GO_1990935	Molecular function	splicing factor binding
GO_0005515	Molecular function	protein binding
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	SF3B5
Protein name	Splicing factor 3B subunit 5 (SF3b5) (Pre-mRNA-splicing factor SF3b 10 kDa subunit)
Synonyms	SF3B10
Description	FUNCTION: Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs . The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing . Within the 17S U2 SnRNP complex, SF3B4 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA . Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA . Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs . .
Accessions	Q9BWJ5 ENST00000367569.4

SF3B5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review