RBMX report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006366Biological processtranscription by RNA polymerase II
GO_0051260Biological processprotein homooligomerization
GO_0001649Biological processosteoblast differentiation
GO_0071347Biological processcellular response to interleukin-1
GO_0048026Biological processpositive regulation of mRNA splicing, via spliceosome
GO_0000381Biological processregulation of alternative mRNA splicing, via spliceosome
GO_0000398Biological processmRNA splicing, via spliceosome
GO_0048025Biological processnegative regulation of mRNA splicing, via spliceosome
GO_0006509Biological processmembrane protein ectodomain proteolysis
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005615Cellular componentextracellular space
GO_0005681Cellular componentspliceosomal complex
GO_0016020Cellular componentmembrane
GO_0000791Cellular componenteuchromatin
GO_0070062Cellular componentextracellular exosome
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0044530Cellular componentsupraspliceosomal complex
GO_0071013Cellular componentcatalytic step 2 spliceosome
GO_1990904Cellular componentribonucleoprotein complex
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0019904Molecular functionprotein domain specific binding
GO_0003682Molecular functionchromatin binding
GO_0042802Molecular functionidentical protein binding
GO_0003729Molecular functionmRNA binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRBMX
Protein nameRNA binding motif protein X-linked
RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed]
SynonymsRBMXP1
HNRPG
DescriptionFUNCTION: RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. .

AccessionsENST00000562646.5
ENST00000565438.1
P38159
H3BR27
ENST00000568578.5
H3BUY5
H0Y6E7
H3BNC1
ENST00000464781.5
ENST00000419968.6
ENST00000320676.11 [P38159-1]
ENST00000431446.7 [P38159-3]
H3BT71
ENST00000563370.1